Chiral Separations Using a Polypeptide and Polymeric Dipeptide Surfactant Polyelectrolyte Multilayer Coating in Open-Tubular Capillary Electrochromatography

2004 ◽  
Vol 76 (22) ◽  
pp. 6681-6692 ◽  
Author(s):  
Mary W. Kamande ◽  
Xiaofeng Zhu ◽  
Constantina Kapnissi-Christodoulou ◽  
Isiah M. Warner
Keyword(s):  
Capillary Electrochromatography ◽  
Multilayer Coating ◽  
Chiral Separations ◽  
Polyelectrolyte Multilayer

Polyelectrolyte multilayer coating with two regulatory molecules on titanium: construction and its biological effects

Nanomedicine ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. 739-755 ◽  
Author(s):  
Qiaojie Luo ◽  
Ying Huang ◽  
Xuliang Deng ◽  
Jianxiang Zhang ◽  
Xiaohui Li ◽  
...  
Keyword(s):  
Biological Effects ◽  
Multilayer Coating ◽  
Polyelectrolyte Multilayer

Analytical and Preparative Scale Separation of Enantiomers of Chiral Drugs by Chromatography and Related Methods

2018 ◽  
Vol 25 (33) ◽  
pp. 4152-4188 ◽  
Author(s):  
Mehmet Gumustas ◽  
Sibel A. Ozkan ◽  
Bezhan Chankvetadze
Keyword(s):  
Capillary Electrochromatography ◽  
High Performance ◽  
Analytical Techniques ◽  
Chiral Separations ◽  
Chiral Drugs ◽  
Preparative Scale ◽  
Enantiomerically Pure ◽  
Separation Of Enantiomers ◽  
Chiral Compounds ◽  
Chiral Pharmaceuticals

While the amino acids, enzymes and hormones are chiral, chirality plays significant role in the life of plants, animals, as well as the human being. Chirality of molecules is important in various industries, such as pharmaceutical, agricultural, food, electronics, etc. Chiral drugs may have different bioavailability, distribution, biotransformation and excretion, as well as quantitatively and/or qualitatively different pharmacological or toxic properties. Enantiomerically pure chiral drugs have been increasingly developed for the pharmaceutical market due to their superiority from the viewpoints of potency and safety. This is supported by the development of new methods for enantioselective production of the chiral compounds, as well as by the capability of the enantioselective analytical methods to allow a detection and quantification of minor enantiomeric impurity in the presence of another enantiomer in a large excess. The aim of the present review is to provide a short summary of the basic principles of chiral separations on an analytical and preparative scale. In addition, some selected applications for analytical techniques, such as gas chromatography, supercritical fluid chromatography, high performance liquid chromatography, capillary electrophoresis and capillary electrochromatography for the separation of enantiomers of chiral pharmaceuticals published in the last two years are also discussed.

scholarly journals Electrically Triggered Release of a Small Molecule Drug from a Polyelectrolyte Multilayer Coating

2010 ◽  
Vol 22 (23) ◽  
pp. 6416-6425 ◽  
Author(s):  
Daniel J. Schmidt ◽  
Joshua S. Moskowitz ◽  
Paula T. Hammond
Keyword(s):  
Small Molecule ◽  
Multilayer Coating ◽  
Triggered Release ◽  
Polyelectrolyte Multilayer ◽  
Small Molecule Drug
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