scholarly journals Ion Mobility Mass Spectrometry Coupled with Rapid Protein Threading Predictor Structure Prediction and Collision-Induced Dissociation for Probing Chemokine Conformation and Stability

2012 ◽  
Vol 84 (7) ◽  
pp. 3208-3214 ◽  
Author(s):  
Milady R. Niñonuevo ◽  
Julie A. Leary
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Structure Prediction ◽  
Collision Induced Dissociation ◽  
Ion Mobility Mass Spectrometry ◽  
Protein Threading

Possible isomers in ligand protected Ag11cluster ions identified by ion mobility mass spectrometry and fragmented by surface induced dissociation

2016 ◽  
Vol 52 (19) ◽  
pp. 3805-3808 ◽  
Author(s):  
Ananya Baksi ◽  
Sophie R. Harvey ◽  
Ganapati Natarajan ◽  
Vicki H. Wysocki ◽  
Thalappil Pradeep
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Collision Induced Dissociation ◽  
Silver Clusters ◽  
Ion Mobility Mass Spectrometry ◽  
Surface Induced Dissociation

Isomeric glutathione protected silver clusters have been detected using ion mobility mass spectrometry. This cluster has been fragmented by conventional collision induced dissociation and newly introduced surface induced dissociation.

Structural analysis of ruthenium–arene complexes using ion mobility mass spectrometry, collision-induced dissociation, and DFT

2016 ◽  
Vol 45 (15) ◽  
pp. 6361-6370 ◽  
Author(s):  
Izabella Czerwinska ◽  
Johann Far ◽  
Christopher Kune ◽  
Carlos Larriba-Andaluz ◽  
Lionel Delaude ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Structural Analysis ◽  
Electrospray Ionization ◽  
Ion Mobility ◽  
Molecular Ions ◽  
Collision Induced Dissociation ◽  
Ion Mobility Mass Spectrometry ◽  
Arene Complexes ◽  
Ruthenium Arene

Electrospray ionization of [RuCl2(p-cymeme)(PTA)] afforded a mixture of two molecular ions resulting from an in source oxidation of RuII into RuIII or from protonation of the 1,3,5-triaza-7-phosphaadamantane (PTA) ligand.

scholarly journals A novel approach to collision-induced dissociation (CID) for ion mobility-mass spectrometry experiments

2009 ◽  
Vol 20 (6) ◽  
pp. 907-914 ◽  
Author(s):  
Christopher Becker ◽  
Francisco A. Fernandez-Lima ◽  
Kent J. Gillig ◽  
William K. Russell ◽  
Stephanie M. Cologna ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Collision Induced Dissociation ◽  
Ion Mobility Mass Spectrometry ◽  
Novel Approach

Rapid Diagnosis of Parkinson’s Disease from Sebum using Paper Spray Ionisation Ion Mobility Mass Spectrometry

2020 ◽  
Author(s):  
Depanjan Sarkar ◽  
Drupad Trivedi ◽  
Eleanor Sinclair ◽  
Sze Hway Lim ◽  
Caitlin Walton-Doyle ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Ion Mobility ◽  
Neurodegenerative Disorder ◽  
Treatment Options ◽  
Ion Mobility Mass Spectrometry ◽  
Paper Spray ◽  
Molecular Features ◽  
Validation Set

Parkinson’s disease (PD) is the second most common neurodegenerative disorder for which identification of robust biomarkers to complement clinical PD diagnosis would accelerate treatment options and help to stratify disease progression. Here we demonstrate the use of paper spray ionisation coupled with ion mobility mass spectrometry (PSI IM-MS) to determine diagnostic molecular features of PD in sebum. PSI IM-MS was performed directly from skin swabs, collected from 34 people with PD and 30 matched control subjects as a training set and a further 91 samples from 5 different collection sites as a validation set. PSI IM-MS elucidates ~ 4200 features from each individual and we report two classes of lipids (namely phosphatidylcholine and cardiolipin) that differ significantly in the sebum of people with PD. Putative metabolite annotations are obtained using tandem mass spectrometry experiments combined with accurate mass measurements. Sample preparation and PSI IM-MS analysis and diagnosis can be performed ~5 minutes per sample offering a new route to for rapid and inexpensive confirmatory diagnosis of this disease.

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