A Microfluidic Vesicle Screening Platform: Monitoring the Lipid Membrane Permeability of Tetracyclines

2011 ◽  
Vol 83 (23) ◽  
pp. 8877-8885 ◽  
Author(s):  
Phillip Kuhn ◽  
Klaus Eyer ◽  
Steffen Allner ◽  
Dario Lombardi ◽  
Petra S. Dittrich
Keyword(s):  
Membrane Permeability ◽  
Lipid Membrane ◽  
Screening Platform

scholarly journals Local Enhancement of Lipid Membrane Permeability Induced by Irradiated Gold Nanoparticles

ACS Nano ◽  
2017 ◽  
Vol 11 (12) ◽  
pp. 12553-12561 ◽  
Author(s):  
Andrea Torchi ◽  
Federica Simonelli ◽  
Riccardo Ferrando ◽  
Giulia Rossi
Keyword(s):  
Gold Nanoparticles ◽  
Membrane Permeability ◽  
Lipid Membrane ◽  
Local Enhancement

scholarly journals The Temperature Dependence And Quantized Nature Of The Lipid Membrane Permeability

2009 ◽  
Vol 96 (3) ◽  
pp. 160a
Author(s):  
Andreas Blicher ◽  
Katarzyna Wodzinska ◽  
Thomas Heimburg
Keyword(s):  
Temperature Dependence ◽  
Membrane Permeability ◽  
Lipid Membrane

scholarly journals The Temperature Dependence of Lipid Membrane Permeability, its Quantized Nature, and the Influence of Anesthetics

2009 ◽  
Vol 96 (11) ◽  
pp. 4581-4591 ◽  
Author(s):  
Andreas Blicher ◽  
Katarzyna Wodzinska ◽  
Matthias Fidorra ◽  
Mathias Winterhalter ◽  
Thomas Heimburg
Keyword(s):  
Temperature Dependence ◽  
Membrane Permeability ◽  
Lipid Membrane

Lipid Membrane Permeability of 2′-Modified Derivatives of Phosphorothioate Oligonucleotides

1994 ◽  
Vol 83 (4) ◽  
pp. 597-600 ◽  
Author(s):  
Jeffrey A. Hughes ◽  
C. Frank Bennett ◽  
P. Dan Cook ◽  
Charles J. Guinosso ◽  
Christopher K. Mirabelli ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Lipid Membrane ◽  
Derivatives Of

Amino acid and peptide hemin derivatives as new promising virucidal agents

2012 ◽  
Vol 16 (03) ◽  
pp. 297-309 ◽  
Author(s):  
Sergei A. Okorochenkov ◽  
Galina A. Zheltukhina ◽  
Vitaly A. Roginsky ◽  
Nikolai N. Nossik ◽  
Sergei L. Zheltukhin ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Membrane Permeability ◽  
Lipid Membranes ◽  
Lipid Membrane ◽  
Model System ◽  
Virucidal Activity ◽  
Liposome Membrane ◽  
Simplex Virus ◽  
Membrane Components ◽  
Modes Of Interaction

We synthesized a series of hemin derivatives (HDs) substituted by residues of amino acids and peptides at either one or two propionic-acid residues, and studied the virucidal activity of the compounds obtained against herpes simplex virus. Compounds 6,7-bis-(methyl ester N0 L-seryl)-protohemin (IX) (2) and 6,7-bis-[methyl ester N0-L-arginyl)-protohemin (IX) (6) shown the highest virucidal activity. We also investigated the interaction between HDs and lipid-membrane components as a possible mechanism of virucidal action. A model system including Clark's electrode and a micellar solution of methyl linoleate was used to quantitatively assess the capability of HDs to catalyze the oxidation of polyunsaturated fatty acids as components of lipid membranes. Another model system including liposomes that consisted of dioleoylphosphatydylcholine and was loaded with the fluorescent dye carboxyfluorescein was employed to examine the effect of HDs on lipid-membrane permeability. The kinetics and efficacy of increasing liposome-membrane permeability on exposure to HDs appeared to depend on the nature of the substituents in the HDs. The findings are strongly suggestive of the presence of two different modes of interaction between an HD and the lipid membrane, i.e. oxidative and non-oxidative mechanisms possibly underlie the virucidal action of HDs.

Sign in / Sign up

Export Citation Format

Share Document