scholarly journals Incubated Protein Reduction and Digestion on an Electrowetting-on-Dielectric Digital Microfluidic Chip for MALDI-MS

2010 ◽  
Vol 82 (23) ◽  
pp. 9932-9937 ◽  
Author(s):  
Wyatt C. Nelson ◽  
Ivory Peng ◽  
Geun-An Lee ◽  
Joseph A. Loo ◽  
Robin L. Garrell ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
Maldi Ms ◽  
Electrowetting On Dielectric ◽  
Digital Microfluidic ◽  
Protein Reduction

An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS

Lab on a Chip ◽  
2006 ◽  
Vol 6 (9) ◽  
pp. 1213 ◽  
Author(s):  
Hyejin Moon ◽  
Aaron R. Wheeler ◽  
Robin L. Garrell ◽  
Joseph A. Loo ◽  
Chang-Jin ?CJ? Kim
Keyword(s):  
Sample Preparation ◽  
Microfluidic Chip ◽  
Maldi Ms ◽  
Digital Microfluidic

Numerical Simulation of Multi-Physical Fields Coupling and Design of a Digital Microfluidics Chip

2012 ◽  
Vol 503 ◽  
pp. 359-365 ◽  
Author(s):  
Tao Chen ◽  
Li Guo Chen ◽  
Ming Qiang Pan ◽  
Ming Xiang Ling ◽  
Li Ning Sun
Keyword(s):  
Numerical Simulation ◽  
Electric Field ◽  
Microfluidic Chip ◽  
Stokes Equations ◽  
Driving Forces ◽  
Geometric Model ◽  
Digital Microfluidics ◽  
Electrowetting On Dielectric ◽  
Physical Fields ◽  
Digital Microfluidic

Due to its simple structure, low consumption of energy but strong driving forces, Electrowetting on Dielectric (EWOD) is used most frequently in digital microfluidics for manipulation and control of droplets. In this paper, the internal mechanism of EWOD is explained though establishing the geometric model of the unipolar board structure digital microfluidic chip. And the boundary conditions of equations are determined. Three coupling physical fields: electric field, flow field and temperature field in the digital microfluidic chip are simulated and analyzed. With the electric field equation coupled, Navier-Stokes equations and energy equation of the temperature control, the numerical simulation of the chip is conducted. The results show that the internal flow of micro-droplets is counterclockwise and swirling flow. The external flow velocity of micro-droplet is greater than the internal velocity. In addition, micro-droplets near the electrode applied temperature are higher than the internal temperature. Surface micromachining technologies are employed to fabricate the chip. Experimental results show that the droplet can be driven in a velocity of 25cm/s. It will possibly provide an effective solution to the manipulation of droplets.

Electrochemical detection on electrowetting-on-dielectric digital microfluidic chip

Talanta ◽  
2011 ◽  
Vol 84 (5) ◽  
pp. 1384-1389 ◽  
Author(s):  
Chanpen Karuwan ◽  
Kreeta Sukthang ◽  
Anurat Wisitsoraat ◽  
Ditsayut Phokharatkul ◽  
Viyapol Patthanasettakul ◽  
...  
Keyword(s):  
Electrochemical Detection ◽  
Microfluidic Chip ◽  
Electrowetting On Dielectric ◽  
Digital Microfluidic

scholarly journals Efficient Radiosynthesis of 3'-Deoxy-3'-18F-Fluorothymidine Using Electrowetting-on-Dielectric Digital Microfluidic Chip

2013 ◽  
Vol 55 (2) ◽  
pp. 321-328 ◽  
Author(s):  
M. R. Javed ◽  
S. Chen ◽  
H.-K. Kim ◽  
L. Wei ◽  
J. Czernin ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
Electrowetting On Dielectric ◽  
Digital Microfluidic

EWOD-Based Digital Microfluidic Chip and its Application

2012 ◽  
Vol 157-158 ◽  
pp. 1071-1074 ◽  
Author(s):  
Yin Xia Chang ◽  
Si Xiang Zhang ◽  
Jian Yi Li
Keyword(s):  
Microfluidic Chip ◽  
Printed Circuit Board ◽  
New Technologies ◽  
New Technology ◽  
Circuit Board ◽  
Commercial Application ◽  
Good Prospect ◽  
Electrowetting On Dielectric ◽  
Major Application ◽  
Digital Microfluidic

As a new technology, digital microfluidic chip based on EWOD (Electrowetting on Dielectric) has good prospect of application in biological, medical, chemical and optic fields. Firstly, the working principle is introduced. Then the major application domains are summarized. Finally, the key problems in design and two fabrication methods are discussed, the clean-room-processing chip is more precise and PCB(Printed Circuit Board) chip is cheaper. New technologies developed in these fields speed up the step from lab to commercial application.

Drop driving on digital microfluidic chip

2020 ◽  
Vol 28 (11) ◽  
pp. 2488-2496
Author(s):  
Hong WANG ◽  
◽  
Jie ZHENG ◽  
Yan-peng YAN ◽  
Song WANG ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
Digital Microfluidic

scholarly journals Phase separation of multiphase droplets in a digital microfluidic device

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Mun Mun Nahar ◽  
Hyejin Moon
Keyword(s):  
Phase Separation ◽  
Capillary Number ◽  
Digital Microfluidics ◽  
Separation Performance ◽  
Comprehensive Investigation ◽  
Electrowetting On Dielectric ◽  
Splitting Technique ◽  
Droplet Splitting ◽  
Two Phases ◽  
Digital Microfluidic

Abstract This study reports the first comprehensive investigation of separation of the immiscible phases of multiphase droplets in digital microfluidics (DMF) platform. Electrowetting-on-dielectric (EWOD) actuation has been used to mechanically separate the phases. Phase separation performance in terms of percentage residue of one phase into another phase has been quantified. It was conceived that the residue formation can be controlled by controlling the deformation of the phases. The larger capillary number of the neck forming phase is associated with the larger amount of deformation as well as more residue. In this study, we propose two different ways to control the deformation of the phases. In the first method, we applied different EWOD operation voltages on two phases to maintain equal capillary numbers during phase separation. In the second method, while keeping the applied voltages same on both sides, we tested the phase separation performance by varying the actuation schemes. Less than 2% of residue was achieved by both methods, which is almost 90% improvement compared to the phase separation by the conventional droplet splitting technique in EWOD DMF platform, where the residue percentage can go up to 20%.

Paper-Based Digital Microfluidic Chip for Multiple Electrochemical Assay Operated by a Wireless Portable Control System

2017 ◽  
Vol 2 (3) ◽  
pp. 1600267 ◽  
Author(s):  
Nipapan Ruecha ◽  
Jumi Lee ◽  
Heedo Chae ◽  
Haena Cheong ◽  
Veasna Soum ◽  
...  
Keyword(s):  
Control System ◽  
Microfluidic Chip ◽  
Electrochemical Assay ◽  
Digital Microfluidic
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