Plasma Phospholipid Metabolic Profiling and Biomarkers of Type 2 Diabetes Mellitus Based on High-Performance Liquid Chromatography/Electrospray Mass Spectrometry and Multivariate Statistical Analysis

2005 ◽  
Vol 77 (13) ◽  
pp. 4108-4116 ◽  
Author(s):  
Chang Wang ◽  
Hongwei Kong ◽  
Yufeng Guan ◽  
Jun Yang ◽  
Jianren Gu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Mass Spectrometry ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Metabolic Profiling ◽  
High Performance ◽  
Electrospray Mass Spectrometry ◽  
Plasma Phospholipid ◽  
Multivariate Statistical

scholarly journals Metabolic Signature Shift in Type 2 Diabetes Mellitus Revealed by Mass Spectrometry-based Metabolomics

2013 ◽  
Vol 98 (6) ◽  
pp. E1060-E1065 ◽  
Author(s):  
Fengguo Xu ◽  
Subramaniam Tavintharan ◽  
Chee Fang Sum ◽  
Kaing Woon ◽  
Su Chi Lim ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Mass Spectrometry ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Metabolic Signature

Discovery of potential biomarkers in exhaled breath for diagnosis of type 2 diabetes mellitus based on GC-MS with metabolomics

RSC Advances ◽  
2014 ◽  
Vol 4 (48) ◽  
pp. 25430-25439 ◽  
Author(s):  
Yanyue Yan ◽  
Qihui Wang ◽  
Wenwen Li ◽  
Zhongjun Zhao ◽  
Xin Yuan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Metabolic Profiling ◽  
Exhaled Breath ◽  
Potential Biomarkers

Eight breath biomarkers of T2DM were discovered by a new SPME-GC-MS based metabolic profiling tool.

scholarly journals Plasma fatty acid metabolic profiling and biomarkers of type 2 diabetes mellitus based on GC/MS and PLS-LDA

FEBS Letters ◽  
2006 ◽  
Vol 580 (30) ◽  
pp. 6837-6845 ◽  
Author(s):  
Lun-Zhao Yi ◽  
Jun He ◽  
Yi-Zeng Liang ◽  
Da-Lin Yuan ◽  
Foo-Tim Chau
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fatty Acid ◽  
Metabolic Profiling ◽  
Plasma Fatty Acid

scholarly journals A Novel Diagnostic Biomarker, PZP, for Detecting Colorectal Cancer in Type 2 Diabetes Mellitus Patients Identified by Serum-Based Mass Spectrometry

2021 ◽  
Vol 8 ◽  
Author(s):  
Jiayue Yang ◽  
Weigang Fang ◽  
Wenjun Wu ◽  
Zhen Tian ◽  
Rong Gao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Colorectal Cancer ◽  
Mass Spectrometry ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diagnostic Value ◽  
Serum Samples ◽  
Data Independent Acquisition ◽  
Ms Analysis

Background: Growing evidence has confirmed that populations with type 2 diabetes mellitus (T2DM) have an increasing risk of developing colorectal cancer (CRC). Thus, convenient and effective screening strategies for CRC should be developed for the T2DM population to increase the detection rate of CRC.Methods: Twenty serum samples extracted from five healthy participants, five T2DM patients, five CRC patients and five T2DM patients with CRC (T2DM + CRC) were submitted to data-independent acquisition mass spectrometry (DIA-MS) analysis to discover unique differentially altered proteins (DAPs) for CRC in patients with T2DM. Then, the diagnostic value of pregnancy zone protein (PZP) was validated by ELISA analysis in the validated cohort.Results: Based on DIA-MS analysis, we found eight unique proteins specific to T2DM patients with CRC. Among these proteins, four proteins showed different expression between the T2DM + CRC and T2DM groups, and PZP exhibited the largest difference. Next, the diagnostic value of serum PZP was validated by ELISA analysis with an AUC of 0.713. Moreover, the combination of PZP, CA199 and CEA exhibited encouraging diagnostic value, and the AUC reached 0.916.Conclusion: Overall, our current research implied that PZP could be regarded as a newfound serum biomarker for CRC medical diagnosis in T2DM patients.

scholarly journals Assessment of the amino acid profile in Thai patients with type 2 diabetes mellitus using liquid chromatography-mass spectrometry

2020 ◽  
Author(s):  
Natthida Sriboonvorakul ◽  
Wirichada Pan-Ngum ◽  
Kittiyod Poovorawan ◽  
Markus Winterberg ◽  
Joel Tarning ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Mass Spectrometry ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Amino Acid ◽  
Glutamic Acid ◽  
Amino Acid Profile ◽  
Liquid Chromatography Mass Spectrometry ◽  
Subgroup Analyses

Abstract Background Type 2 diabetes mellitus (T2DM) is a global health problem. Early identification of those at risk is necessary to prevent its onset through lifestyle and pharmacologic interventions. T2DM is characterized by metabolic abnormalities, including protein metabolism. Evaluation of the amino acid profile might be beneficial for early assessment. Methods Liquid chromatography-mass spectrometry was performed to separate and quantify plasma amino acids from two groups of Thai individuals, patients with T2DM (n=103) and healthy individuals (n=104). Multivariate analysis was applied to compare free amino acid levels between groups. Subgroup analyses of patients with T2DM were performed to assess the association between amino acid profiles and important T2DM clinical characteristics. Results The multivariate analysis showed that glutamic acid was significantly associated with T2DM (OR 1.113, 95% CI 1.006 to 1.231) and results from the subgroup analyses showed that this correlation was significant in all subgroups of patients (p<0.05). Conclusions This finding needs to be confirmed in larger groups of patients with T2DM to explore glutamic acid as a biomarker for early prevention in particular at-risk groups. An in-depth understanding of the involvement of glutamic acid in T2DM could enhance our understanding of the disease and potentially provide novel interventions.

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