Speciation of Dimethylarsinous Acid and Trimethylarsine Oxide in Urine from Rats Fed with Dimethylarsinic Acid and Dimercaptopropane Sulfonate

2003 ◽  
Vol 75 (23) ◽  
pp. 6463-6468 ◽  
Author(s):  
Xiufen Lu ◽  
Lora L. Arnold ◽  
Samuel M. Cohen ◽  
William R. Cullen ◽  
X. Chris Le
Keyword(s):  
Dimethylarsinic Acid ◽  
Dimethylarsinous Acid ◽  
Trimethylarsine Oxide

A comparative study on acute toxicity of methylarsonic acid, dimethylarsinic acid and trimethylarsine oxide in mice

1989 ◽  
Vol 3 (3) ◽  
pp. 273-277 ◽  
Author(s):  
Toshikazu Kaise ◽  
Hiroshi Yamauchi ◽  
Yoshiya Horiguchi ◽  
Takayuki Tani ◽  
Shigenobu Watanabe ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Comparative Study ◽  
Dimethylarsinic Acid ◽  
Methylarsonic Acid ◽  
Trimethylarsine Oxide

In vitro biotransformation of dimethylarsinic acid and trimethylarsine oxide by anaerobic microflora of mouse cecum analyzed by HPLC-ICP-MS and HPLC-ESI-MS

2009 ◽  
Vol 24 (8) ◽  
pp. 1062 ◽  
Author(s):  
Kevin M. Kubachka ◽  
Michael C. Kohan ◽  
Sean D. Conklin ◽  
Karen Herbin-Davis ◽  
John T. Creed ◽  
...  
Keyword(s):  
Dimethylarsinic Acid ◽  
Esi Ms ◽  
Icp Ms ◽  
Mouse Cecum ◽  
Trimethylarsine Oxide ◽  
Anaerobic Microflora

Possible Role of Dimethylarsinous Acid in Dimethylarsinic Acid-Induced Urothelial Toxicity and Regeneration in the Rat

2002 ◽  
Vol 15 (9) ◽  
pp. 1150-1157 ◽  
Author(s):  
Samuel M. Cohen ◽  
Lora L. Arnold ◽  
Eva Uzvolgyi ◽  
Martin Cano ◽  
Margaret St. John ◽  
...  
Keyword(s):  
Dimethylarsinic Acid ◽  
Dimethylarsinous Acid

scholarly journals Importance of monitoring arsenic methylation metabolism in acute promyelocytic leukemia patients receiving the treatment of arsenic trioxide

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Yu Zheng ◽  
Yuan-Fei Mao ◽  
Hui-Jin Zhao ◽  
Li Chen ◽  
Li-Ning Wang ◽  
...  
Keyword(s):  
Arsenic Trioxide ◽  
Acute Promyelocytic Leukemia ◽  
Arsenic Speciation ◽  
Promyelocytic Leukemia ◽  
Chronic Liver ◽  
Dimethylarsinic Acid ◽  
Metabolic Pattern ◽  
Methylation Index ◽  
Arsenic Methylation

Abstract Background Arsenic trioxide [ATO, inorganic arsenite (iAsIII) in solution] plays an important role in the treatment of acute promyelocytic leukemia (APL). However, the long-term adverse effects (AEs) and the retention of arsenic among APL patients are rarely reported. In this study, we focused on arsenic methylation metabolism and its relationship with chronic hepatic toxicity, as we previously reported, among APL patients who had finished the treatment of ATO. Methods A total of 112 de novo APL patients who had completed the ATO-containing treatment were enrolled in the study. Arsenic species [iAsIII, inorganic arsenate (iAsV), and their organic metabolites, monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA)] in patients’ plasma, urine, hair and nails were detected by high-performance liquid chromatography combined with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). Eighteen single nucleotide polymorphisms (SNPs) of the arsenic (+ 3 oxidative state) methylation transferase (AS3MT) gene, which was known as the main catalyzer for arsenic methylation, were tested with the polymerase chain reaction method. Results The study showed the metabolic pattern of arsenic in APL patients undergoing and after the treatment of ATO, in terms of total arsenic (TAs) and four species of arsenic. TAs decreased to normal after 6 months since cessation of ATO. But the arsenic speciation demonstrated significantly higher portion of iAsIII in patient’s urine (40.08% vs. 1.94%, P < 0.001), hair (29.25% vs. 13.29%, P = 0.002) and nails (30.21% vs. 13.64%, P = 0.003) than the healthy controls’, indicating a decreased capacity of arsenic methylation metabolism after the treatment of ATO. Urine primary methylation index (PMI) was significantly lower in patients with both chronic liver dysfunction (0.14 vs. 0.28, P = 0.047) and hepatic steatosis (0.19 vs. 0.3, P = 0.027), suggesting that insufficient methylation of arsenic might be related to chronic liver disorders. Two SNPs (A9749G and A27215G) of the AS3MT gene were associated with impaired urine secondary methylation index (SMI). Conclusions The long-term follow-up of arsenic speciation indicated a decreased arsenic methylation metabolism and a probable relationship with chronic hepatic disorders among APL patients after the cessation of ATO. Urine PMI could be a monitoring index for chronic AEs of ATO, and the SNPs of AS3MT gene should be considered when determining the dosage of ATO.

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