Electrokinetic Injection Techniques in Microfluidic Chips

2002 ◽  
Vol 74 (19) ◽  
pp. 5084-5091 ◽  
Author(s):  
L.-M. Fu ◽  
R.-J. Yang ◽  
G.-B. Lee ◽  
H.-H. Liu
2000 ◽  
Vol 72 (15) ◽  
pp. 3512-3517 ◽  
Author(s):  
Sergey V. Ermakov ◽  
Stephen C. Jacobson ◽  
J. Michael Ramsey

2006 ◽  
Vol 505-507 ◽  
pp. 409-414
Author(s):  
Yao Nan Wang ◽  
Chiufeng Lin ◽  
S.T. Wu ◽  
C.L. Chang ◽  
H.T. Chen ◽  
...  

This paper presents an experimental investigation on the use of high-resolution injection techniques to deliver sample plugs within electrophoresis microchips. Two novel injection microfluidic chips are proposed, which employ conventional cross-shaped and U-shaped injection system combined with an expander to deliver high-quality sample plugs for detection in separation channel. The valving characteristics on microfluidic devices are controlled through appropriate manipulations of the electric potential strengths during the sample injection and separation steps. These novel injection techniques developed in this study has an exciting potential for use in high-quality, high-throughput chemical analysis applications and in many other applications throughout the field of micro-total-analysis systems.


2005 ◽  
Vol 26 (3) ◽  
pp. 674-686 ◽  
Author(s):  
Chien-Hsiung Tsai ◽  
Ruey-Jen Yang ◽  
Chang-Hsien Tai ◽  
Lung-Ming Fu

2018 ◽  
Author(s):  
Muhammad Salman Khan ◽  
Afia Asif ◽  
Saed Khawaldeh ◽  
Ahmet Tekin

Gold electrodes are often not suitable for the dopamine measurements as dopamine creates a non-conducting polymer layer on the surface of the electrodes, which leads to the increased amount of electrode passivity with the gradual increase in voltammograms measurement. This work presents the impedance spectroscopy and cyclic-voltammetry comparitive study for dopamine detection with two modifications for the surface of Au electrodes i.e., (1) Cysteamine and (2) Mercaptopropionic Acid (MPA) for thermally bonded and ultrasonically welded microfluidic chips respectively. The effects of optimized tubing selection, bonding techniques, and cleaning methods of the devices with KOH solution played crucial role for improvements in dopamine detection which are observed in results. Furthermore, comparison for the modification with unmodified chips, and finding the unknown concentration of dopamine solution using flow injection techniques is also illustrated.


2018 ◽  
Vol 9 (1) ◽  
pp. 3-9
Author(s):  
Muhammad Salman Khan ◽  
Afia Asif ◽  
Saed Khawaldeh ◽  
Ahmet Tekin

Abstract Gold electrodes are often not suitable for dopamine measurements as dopamine creates a non-conducting polymer layer on the surface of the electrodes, which leads to increased amount of electrode passivity with the gradual increase in voltammograms measurement. This work presents the impedance spectroscopy and cyclic-voltammetry comparative study for dopamine detection with two modifications for the surface of Au electrodes; cysteamine and mercaptopropionic acid for thermally bonded and ultrasonically welded microfluidic chips, respectively. The effects of optimized tubing selection, bonding techniques, and cleaning methods of the devices with KOH solution played crucial role for improvements in dopamine detection, which are observed in the results. Furthermore, comparison for the modification with unmodified chips, and finding the unknown concentration of dopamine solution using flow injection techniques, is also illustrated.


Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2189-PUB
Author(s):  
FAN LI ◽  
ANNE FISH ◽  
UMIT TOKAC

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