Fourier transforms in the computation of self-deconvoluted and first-order derivative spectra of overlapped band contours

1981 ◽  
Vol 53 (9) ◽  
pp. 1454-1457 ◽  
Author(s):  
Jyrki K. Kauppinen ◽  
Douglas J. Moffatt ◽  
Henry H. Mantsch ◽  
David G. Cameron
Keyword(s):  
Fourier Transforms ◽  
Order Derivative ◽  
First Order ◽  
Derivative Spectra

scholarly journals UV Spectrophotometric Method for theEstimation of Itopride Hydrochloride in Pharmaceutical Formulation

2010 ◽  
Vol 7 (s1) ◽  
pp. S49-S54 ◽  
Author(s):  
K. R. Gupta ◽  
R. R. Joshi ◽  
R. B. Chawla ◽  
S. G. Wadodkar
Keyword(s):  
Wavelength Range ◽  
Spectrophotometric Method ◽  
Area Under Curve ◽  
Pharmaceutical Formulations ◽  
Sharp Peak ◽  
Order Derivative ◽  
Distilled Water ◽  
First Order ◽  
Derivative Spectra ◽  
Itopride Hydrochloride

Three simple, precise and economical UV methods have been developed for the estimation of itopride hydrochloride in pharmaceutical formulations. Itopride hydrochloride in distilled water shows the maximum absorbance at 258.0 nm (Method A) and in first order derivative spectra of the same shows sharp peak at 247.0 nm, when n = 1 (Method B). Method C utilises area under curve (AUC) in the wavelength range from 262.0-254.0 nm for analysis of itopride hydrochloride. The drug was found to obey Beer-Lambert’s law in the concentration range of 5-50 μg/mL for all three proposed methods. Results of the analysis were validated statistically and recovery studies were found to be satisfactory.

scholarly journals Development and Statistical Validation of Spectrophotometric Methods for the Estimation of Nabumetone in Tablet Dosage Form

2010 ◽  
Vol 7 (4) ◽  
pp. 1463-1467 ◽  
Author(s):  
A. R. Rote ◽  
S. R. Bhalerao
Keyword(s):  
Area Under Curve ◽  
Dosage Form ◽  
Correlation Coefficients ◽  
Order Derivative ◽  
Statistical Validation ◽  
First Order ◽  
Spectrophotometric Methods ◽  
Derivative Spectra ◽  
Pharmaceutical Tablet ◽  
Tablet Dosage

Three new simple, economic spectrophotometric methods were developed and validated for the estimation of nabumetone in bulk and tablet dosage form. First method includes determination of nabumetone at absorption maxima 330 nm, second method applied was area under curve for analysis of nabumetone in the wavelength range of 326-334 nm and third method was First order derivative spectra with scaling factor 4. Beer law obeyed in the concentration range of 10-30 μg/mL for all three methods. The correlation coefficients were found to be 0.9997, 0.9998 and 0.9998 by absorption maxima, area under curve and first order derivative spectra. Results of analysis were validated statistically and by performing recovery studies. The mean percent recoveries were found satisfactory for all three methods. The developed methods were also compared statistically using one way ANOVA. The proposed methods have been successfully applied for the estimation of nabumetone in bulk and pharmaceutical tablet dosage form.

A Generalized Approach to Derivative Spectroscopy

1987 ◽  
Vol 41 (4) ◽  
pp. 539-544 ◽  
Author(s):  
David G. Cameron ◽  
Douglas J. Moffatt
Keyword(s):  
Fourier Transforms ◽  
Order Derivative ◽  
Signal To Noise ◽  
Derivative Spectra ◽  
Derivative Spectroscopy ◽  
Even Order

A general approach to obtaining smoothed even-order derivative spectra using Fourier transforms is developed. The method is easier to use and yields higher signal-to-noise ratios than do techniques which involve the use of convolution functions.

scholarly journals Estimation of Tadalafil Using Derivative Spectrophotometry in Bulk Material and in Pharmaceutical Formulation

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Zamir G. Khan ◽  
Amod S. Patil ◽  
Atul A. Shirkhedkar
Keyword(s):  
Wavelength Range ◽  
Area Under Curve ◽  
Pharmaceutical Formulation ◽  
Second Order ◽  
Order Derivative ◽  
Uv Spectrophotometry ◽  
First Order ◽  
Beer's Law ◽  
Beer’S Law ◽  
Derivative Uv Spectrophotometry

Four simple, rapid, accurate, precise, reliable, and economical UV-spectrophotometric methods have been proposed for the determination of tadalafil in bulk and in pharmaceutical formulation. “Method A” is first order derivative UV spectrophotometry using amplitude, “method B” is first order derivative UV spectrophotometry using area under curve technique, “method C” is second order derivative UV spectrophotometry using amplitude, and “method D” is second order derivative UV spectrophotometry using area under curve technique. The developed methods have shown best results in terms of linearity, accuracy, precision, and LOD and LOQ for bulk drug and marketed formulation as well. In N,N-dimethylformamide, tadalafil showed maximum absorbance at 284 nm. For “method A” amplitude was recorded at 297 nm while for “method B” area under curve was integrated in the wavelength range of 290.60–304.40 nm. For “method C” amplitude was measured at 284 nm while for “method D” area under curve was selected in the wavelength range of 280.80–286.20 nm. For methods A and B, tadalafil obeyed Lambert-Beer’s law in the range of 05–50 μg/mL while for “methods C and D”, tadalafil obeyed Lambert-Beer’s law in the range of 20–70 μg/mL, and-for “methods A, B, C, and D” the correlation coefficients were found to be > than 0.999.

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