Simultaneous determination of phenytoin, barbital and caffeine in pharmaceuticals by absorption (zero-order) UV spectra and first-order derivative spectra—multivariate calibration methods

2005 ◽  
Vol 38 (3) ◽  
pp. 420-427 ◽  
Author(s):  
A. Abbaspour ◽  
R. Mirzajani
Keyword(s):  
Simultaneous Determination ◽  
Multivariate Calibration ◽  
Uv Spectra ◽  
Zero Order ◽  
Order Derivative ◽  
First Order ◽  
Derivative Spectra ◽  
Calibration Methods

scholarly journals UV Spectrophotometric Simultaneous Determination of Paracetamol and Ibuprofen in Combined Tablets by Derivative and Wavelet Transforms

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Vu Dang Hoang ◽  
Dong Thi Ha Ly ◽  
Nguyen Huu Tho ◽  
Hue Minh Thi Nguyen
Keyword(s):  
Simultaneous Determination ◽  
Wavelet Transforms ◽  
Hybrid Approach ◽  
Uv Spectra ◽  
Order Derivative ◽  
First Order ◽  
Spectrophotometric Methods ◽  
Combined Use ◽  
Linear Concentration

The application of first-order derivative and wavelet transforms to UV spectra and ratio spectra was proposed for the simultaneous determination of ibuprofen and paracetamol in their combined tablets. A new hybrid approach on the combined use of first-order derivative and wavelet transforms to spectra was also discussed. In this application, DWT (sym6 and haar), CWT (mexh), and FWT were optimized to give the highest spectral recoveries. Calibration graphs in the linear concentration ranges of ibuprofen (12–32 mg/L) and paracetamol (20–40 mg/L) were obtained by measuring the amplitudes of the transformed signals. Our proposed spectrophotometric methods were statistically compared to HPLC in terms of precision and accuracy.

scholarly journals Simultaneous Determination of Promethazine, Chlorpromazine, and Perphenazine by Multivariate Calibration Methods and Derivative Spectrophotometry

2002 ◽  
Vol 85 (3) ◽  
pp. 555-562 ◽  
Author(s):  
Mojtaba Shamsipur ◽  
Bahram Hemmateenejad ◽  
Morteza Akhond
Keyword(s):  
Simultaneous Determination ◽  
Multivariate Calibration ◽  
Derivative Spectrophotometry ◽  
Derivative Spectra ◽  
Calibration Methods ◽  
Artificial Neural Network Ann ◽  
Comparison Of The Results ◽  
Value Decomposition ◽  
Phenothiazine Drugs

Abstract Partial least-squares (PLS) regression, singular value decomposition-based PLS, and an artificial neural network (ANN) were tested as calibration procedures for the simultaneous determination of promethazine, chlorpromazine, and perphenazine by both conventional and derivative spectrophotometry. Comparison of the results revealed that the application of the ANN to the derivative spectra is superior to the application of the 2 PLS methods used. Different binary and ternary synthetic mixtures of the phenothiazine drugs in pure form and in tablets were analyzed by the proposed method, and acceptable results were obtained.

Simultaneous Determination of Tramadol and Ibuprofen in Pharmaceutical Preparations by First Order Derivative Spectrophotometric and LC Methods

2008 ◽  
Vol 68 (9-10) ◽  
pp. 843-847 ◽  
Author(s):  
A. B. Thomas ◽  
N. G. Dumbre ◽  
R. K. Nanda ◽  
L. P. Kothapalli ◽  
A. A. Chaudhari ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Pharmaceutical Preparations ◽  
Order Derivative ◽  
First Order

Cyclic voltammetric simultaneous determination of oxidizable amino acids using multivariate calibration methods

2000 ◽  
Vol 405 (1-2) ◽  
pp. 153-160 ◽  
Author(s):  
Javier Saurina ◽  
Santiago Hernández-Cassou ◽  
Esteve Fàbregas ◽  
Salvador Alegret
Keyword(s):  
Amino Acids ◽  
Simultaneous Determination ◽  
Multivariate Calibration ◽  
Cyclic Voltammetric ◽  
Calibration Methods

scholarly journals Individual and simultaneous determinations of phenothiazine drugs using PCR, PLS and (OSC)-PLS multivariate calibration methods

2008 ◽  
Vol 73 (2) ◽  
pp. 233-247 ◽  
Author(s):  
Mohammad Karimi ◽  
Mazloum Ardakani ◽  
Reza Behjatmanesh-Ardakani ◽  
Hormozi Nezhad ◽  
Hamzeh Amiryan
Keyword(s):  
Simultaneous Determination ◽  
Multivariate Calibration ◽  
Phenothiazine Derivatives ◽  
Colored Complex ◽  
Calibration Methods ◽  
Orthogonal Signal Correction ◽  
The Individual ◽  
Mean Square Errors ◽  
Phenothiazine Drugs

Individual and simultaneous determinations of some phenothiazine drugs are described. The individual determination method is based on the reaction of chlorpromazine hydrochloride (CPH), promethazine hydrochloride (PH), trifluoperazine hydrochloride (TFPH), trimipramine maleate (TPM) and thioridazine hydrochloride (TRDH) with complex of [Fe(Bpy)3]3+. In the presence of phenothiazine derivatives, [Fe(Bpy)3]3+ is reduced easily to the colored complex [Fe(Bpy)3]2+, which shows an absorption maximum at 525 nm. The individual method is highly sensitive and suitable for 0.3-190 ?g ml-1 concentrations, with detection limits in the range 0.18-2.46 ?g ml-1. Simultaneous kinetic-spectrophotometric determination of ternary mixture of CPH, PH and TPM using principal component regression (PCR), partial least squares (PLS) and orthogonal signal correction (OSC)-PLS multivariate calibration methods is also described. The simultaneous methods are based on the difference observed in the reduction rate of the [Fe(Bpy)3]3+ complex with CPH, PH and TPM in acidic media. The results showed that the simultaneous determination of CPH, PH and TPM can be performed in the concentration ranges of 0.5-120.0, 0.3-80.0 and 5.0-100.0 ?g ml-1, respectively, for three methods (PCR, PLS and OSC-PLS). The root mean square errors of prediction (RMSEP) of CPH, PH and TPM were 0.346, 0.663 and 0.820 (for PCR) 0.317, 0.659 and 0.830 (for PLS) and 0.087, 0.124 and 0.085 (for OSC-PLS), respectively. The proposed methods were successfully applied to the individual and simultaneous determination of phenothiazine derivatives in pharmaceutical preparations, the results of which compared well with those obtained by the official method, and several synthetic (spiked) samples, whereby satisfactory results were obtained.

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