Constant neutral loss scanning for the characterization of bacterial phospholipids desorbed by fast atom bombardment

1988 ◽  
Vol 60 (24) ◽  
pp. 2787-2791 ◽  
Author(s):  
D. N. Heller ◽  
C. M. Murphy ◽  
R. J. Cotter ◽  
C. Fenselau ◽  
O. M. Uy
Keyword(s):  
Fast Atom Bombardment ◽  
Neutral Loss ◽  
Constant Neutral Loss ◽  
Neutral Loss Scanning

Constant neutral loss scanning for the characterization of glycerol phosphatidylcholine phospholipids

1998 ◽  
Vol 9 (11) ◽  
pp. 1189-1195 ◽  
Author(s):  
Pedro Domingues ◽  
Francisco M. L. Amado ◽  
M. Graça O. Santana-Marques ◽  
A. J. Ferrer-Correia
Keyword(s):  
Neutral Loss ◽  
Constant Neutral Loss ◽  
Neutral Loss Scanning

Carboxylic acid functional group analysis using constant neutral loss scanning-mass spectrometry

2007 ◽  
Vol 605 (1) ◽  
pp. 61-69 ◽  
Author(s):  
Julien Dron ◽  
Gregory Eyglunent ◽  
Brice Temime-Roussel ◽  
Nicolas Marchand ◽  
Henri Wortham
Keyword(s):  
Mass Spectrometry ◽  
Carboxylic Acid ◽  
Functional Group ◽  
Neutral Loss ◽  
Group Analysis ◽  
Constant Neutral Loss ◽  
Functional Group Analysis ◽  
Acid Functional Group ◽  
Neutral Loss Scanning

Fast Atom Bombardment Mass Spectrometric Characterization of Poly(O-Toluidine)

1991 ◽  
Author(s):  
K. Balasaunmugam ◽  
K. G. Owens ◽  
K. F. Hsueh ◽  
P. Hoontrakul ◽  
M. A. Olsen
Keyword(s):  
Fast Atom Bombardment ◽  
Mass Spectrometric

scholarly journals Identification of New Markers of Alcohol-Derived DNA Damage in Humans

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 366
Author(s):  
Valeria Guidolin ◽  
Erik S. Carlson ◽  
Andrea Carrà ◽  
Peter W. Villalta ◽  
Laura A. Maertens ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Adducts ◽  
Neutral Loss ◽  
Alcohol Exposure ◽  
Dose Dependence ◽  
Accurate Mass ◽  
Constant Neutral Loss ◽  
Covalent Modifications ◽  
Underlying Mechanisms

Alcohol consumption is a risk factor for the development of several cancers, including those of the head and neck and the esophagus. The underlying mechanisms of alcohol-induced carcinogenesis remain unclear; however, at these sites, alcohol-derived acetaldehyde seems to play a major role. By reacting with DNA, acetaldehyde generates covalent modifications (adducts) that can lead to mutations. Previous studies have shown a dose dependence between levels of a major acetaldehyde-derived DNA adduct and alcohol exposure in oral-cell DNA. The goal of this study was to optimize a mass spectrometry (MS)-based DNA adductomic approach to screen for all acetaldehyde-derived DNA adducts to more comprehensively characterize the genotoxic effects of acetaldehyde in humans. A high-resolution/-accurate-mass data-dependent constant-neutral-loss-MS3 methodology was developed to profile acetaldehyde-DNA adducts in purified DNA. This resulted in the identification of 22 DNA adducts. In addition to the expected N2-ethyldeoxyguanosine (after NaBH3CN reduction), two previously unreported adducts showed prominent signals in the mass spectra. MSn fragmentation spectra and accurate mass were used to hypothesize the structure of the two new adducts, which were then identified as N6-ethyldeoxyadenosine and N4-ethyldeoxycytidine by comparison with synthesized standards. These adducts were quantified in DNA isolated from oral cells collected from volunteers exposed to alcohol, revealing a significant increase after the exposure. In addition, 17 of the adducts identified in vitro were detected in these samples confirming our ability to more comprehensively characterize the DNA damage deriving from alcohol exposures.

Characterization of α-amino acidato chromium(III) complexes by fast atom bombardment mass spectrometry

Polyhedron ◽  
1996 ◽  
Vol 15 (17) ◽  
pp. 2887-2894 ◽  
Author(s):  
Teresa M. Santos ◽  
Júlio D. Pedrosa de Jesus ◽  
Francisco M.L. Amado ◽  
Pedro M. Domingues ◽  
M. Graça Santana-Marques ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fast Atom Bombardment
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