Effect of Affinity for Droplet Surfaces on the Fraction of Analyte Molecules Charged during Electrospray Droplet Fission

2001 ◽  
Vol 73 (19) ◽  
pp. 4632-4639 ◽  
Author(s):  
Nadja B. Cech ◽  
Christie G. Enke
Keyword(s):  
Processes ◽  
2020 ◽  
Vol 8 (5) ◽  
pp. 510
Author(s):  
Inn-Leon Lu ◽  
Voon-Loong Wong ◽  
Jit-Kai Chin ◽  
Kuzilati Kushaari

Droplet fission has gained notable interest in drug delivery applications due to its ability to perform parallel operations in single device. Hitherto, droplet flow behavior in a 3D constriction was scarcely investigated. This study aims to investigate droplets fission inside a 3D bi-planar multifurcated microfluidic device. The flow behavior and droplet size distribution were studied in trifurcated microchannels using distilled water as dispersed phase (1 mPa·s) and olive oil (68 mPa·s) as continuous phase. Various sizes of subordinate daughter droplets were manipulated passively through the modulation of flowrate ratio (Q) (0.15 < Q < 3.33). Overall, we found droplet size coefficient of variations (CV%) ranging from 0.72% to 69%. Highly monodispersed droplets were formed at the upstream T-junction (CV% < 2%) while the droplet fission process was unstable at higher flowrate ratio (Q > 0.4) as they travel downstream (1.5% < CV% < 69%) to splitting junctions. Complex responses to the non-monotonic behavior of mean droplet size was found at the downstream boundaries, which arose from the deformations under nonuniform flow condition. CFD was used as a tool to study the preliminary maximum velocity (Umax) profile for the symmetrical (0.01334 m/s < Umax < 0.0153 m/s) and asymmetrical branched channels (0.0223 m/s< Umax < 0.00438 m/s), thus complementing the experimental model studies.


2017 ◽  
Vol 140 (1) ◽  
Author(s):  
Yong Ren ◽  
Kai Seng Koh ◽  
Jit Kai Chin ◽  
Jing Wang ◽  
Conghua Wen ◽  
...  

With a novel platform of bilayer polydimethylsiloxane microchannel formed by bifurcating junction, we aim to investigate droplet formation and fission in a multiphase system with complex three-dimensional (3D) structure and understand the variations in mechanism associated with droplet formation and fission in the microstructure between shear-thinning/Newtonian system versus Newtonian/Newtonian system. The investigation concentrates on shear-thinning fluid because it is one of the most ubiquitous rheological properties of non-Newtonian fluids. Sodium carboxymethyl cellulose (CMC) solution and silicone oil have been used as model fluids and numerical model has been established to characterize the shear-thinning effect in formation of CMC-in-oil emulsions, as well as breakup dynamics when droplets flow through 3D bifurcating junction. The droplet volume and generation rate have been compared between two systems at the same Weber number and capillary number. Variation in droplet fission has been found between two systems, demonstrating that the shear-thinning property and confining geometric boundaries significantly affect the deformation and breakup of each mother droplet into two daughter droplets at bifurcating junction. The understanding of the droplet fission in the novel microstructure will enable more versatile control over the emulsion formation and fission when non-Newtonian fluids are involved. The model systems in the study can be further developed to investigate the mechanical property of emulsion templated particles such as drug encapsulated microcapsules when they flow through complex media structures, such as blood capillaries or the porous tissue structure, which feature with bifurcating junction.


Langmuir ◽  
1989 ◽  
Vol 5 (2) ◽  
pp. 376-384 ◽  
Author(s):  
Daniel C. Taflin ◽  
Timothy L. Ward ◽  
E. James Davis

RSC Advances ◽  
2014 ◽  
Vol 4 (59) ◽  
pp. 31184-31187 ◽  
Author(s):  
Yong Wang ◽  
Ping Wu ◽  
Zhaofeng Luo ◽  
Yuting Li ◽  
Meixiang Liao ◽  
...  

We describe a cheap, easily assembled, controllable droplet fission device to obtain a variety of uniform daughter droplets.


1997 ◽  
Vol 9 (6) ◽  
pp. 1573-1590 ◽  
Author(s):  
Michael P. Brenner ◽  
Jens Eggers ◽  
Kathy Joseph ◽  
Sidney R. Nagel ◽  
X. D. Shi

2001 ◽  
Vol 86 (16) ◽  
pp. 3558-3561 ◽  
Author(s):  
Y. Amarouchene ◽  
D. Bonn ◽  
J. Meunier ◽  
H. Kellay

1983 ◽  
Vol 126 (6) ◽  
pp. 425-427 ◽  
Author(s):  
Ulrich Brosa ◽  
Siegfried Grossmann

1994 ◽  
Vol 73 (25) ◽  
pp. 3391-3394 ◽  
Author(s):  
Michael P. Brenner ◽  
X. D. Shi ◽  
Sidney R. Nagel
Keyword(s):  

Science ◽  
1939 ◽  
Vol 89 (2305) ◽  
pp. 202-203 ◽  
Author(s):  
M. A. Tuve
Keyword(s):  

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