scholarly journals The NAS-NRC Twin Registry and Duke Twins Study of Memory in Aging: An Update

2019 ◽  
Vol 22 (6) ◽  
pp. 757-760 ◽  
Author(s):  
Margaret Gatz ◽  
Brenda L. Plassman ◽  
Caroline M. Tanner ◽  
Samuel M. Goldman ◽  
Gary E. Swan ◽  
...  
Keyword(s):  
World War Ii ◽  
Human Genetics ◽  
White Male ◽  
National Research Council ◽  
Armed Forces ◽  
National Archive ◽  
Population Based ◽  
National Academy Of Sciences ◽  
Twin Registry ◽  
Academy Of Sciences

AbstractThe National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry is one of the oldest, national population-based twin registries in the USA. It comprises 15,924 White male twin pairs born in the years 1917–1927 (N = 31.848), both of whom served in the armed forces, chiefly during World War II. This article updates activities in this registry since the most recent report in Twin Research and Human Genetics (Page, 2006). Records-based data include information from enlistment charts and Veterans Administration data linkages. There have been three major epidemiologic questionnaires and an education and earnings survey. Separate data collection efforts with the NAS-NRC registry include the National Heart, Lung, and Blood Institute (NHLBI) subsample, the Duke Twins Study of Memory in Aging and a clinically based study of Parkinson’s disease. Progress has been made on consolidating the various data holdings of the NAS-NRC Twin Registry. Data that had been available through the National Academy of Sciences are now freely available through National Archive of Computerized Data on Aging (NACDA).

scholarly journals Genetic and Environmental Influences on Blood Pressure and Body Mass Index in the National Academy of Sciences–National Research Council World War II Veteran Twin Registry

Hypertension ◽  
2020 ◽  
Vol 76 (5) ◽  
pp. 1428-1434
Author(s):  
Bin Wang ◽  
Ting Wu ◽  
Michael C. Neale ◽  
Renske Verweij ◽  
Gaifen Liu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
World War Ii ◽  
Research Council ◽  
National Research Council ◽  
World War ◽  
National Academy Of Sciences ◽  
Twin Registry ◽  
World War Ii Veteran ◽  
Academy Of Sciences

Blood pressure (BP) and obesity phenotypes may covary due to shared genetic or environmental factors or both. Furthermore, it is possible that the heritability of BP differs according to obesity status—a form of G×E interaction. This hypothesis has never been tested in White twins. The present study included 15 924 White male twin pairs aged between 15 and 33 years from the National Academy of Sciences–National Research Council World War II Veteran Twin Registry. Systolic and diastolic BPs, as well as height and weight, were measured at the induction physical examination. Body mass index (BMI) was used as the index of general obesity. Quantitative genetic modeling was performed using Mx software. Univariate analysis showed that narrow sense heritabilities (95% CI) for systolic BP, diastolic BP, height, and BMI were 0.401 (0.381–0.420), 0.297 (0.280–0.320), 0.866 (0.836–0.897), and 0.639 (0.614–0.664), respectively. Positive phenotypic correlations of BMI with systolic BP (r=0.13) and diastolic BP (r=0.08) were largely due to genetic factors (70% and 86%, respectively). The gene-BMI interaction analysis did not show any support for a modifying effect of BMI on genetic and environmental influences of systolic BP and diastolic BP. Our results suggest that correlations between BP and BMI are mainly explained by common genes influencing both. Higher BMI levels have no influence on the penetrance of genetic vulnerability to elevated BP. These conclusions may prove valuable for gene-finding studies.

Duke Twins Study of Memory in Aging in the NAS-NRC Twin Registry

2006 ◽  
Vol 9 (6) ◽  
pp. 950-957 ◽  
Author(s):  
Brenda L. Plassman ◽  
David C. Steffens ◽  
James R. Burke ◽  
Kathleen A. Welsh-Bohmer ◽  
Tiffany N. Newman ◽  
...  
Keyword(s):  
World War Ii ◽  
National Research Council ◽  
Cognitive Change ◽  
Population Based ◽  
Cognitive Screening ◽  
National Academy Of Sciences ◽  
Twin Registry ◽  
Male Veterans ◽  
Screening Protocol ◽  
Diagnosis Of Dementia

AbstractThe Duke Twins Study of Memory in Aging is an ongoing, longitudinal study of cognitive change and dementia in the population-based National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry of World War II Male Veterans. The primary goal of this study has been to estimate the overall genetic and environmental contributions to dementia with a specific focus on Alzheimer's disease. An additional goal has been to examine specific genetic and environmental antecedents of cognitive decline and dementia. Since 1989, we have completed 4 waves of data collection. Each wave included a 2-phase telephone cognitive screening protocol, followed by an in-home standardized clinical assessment for those with suspected dementia. For many participants, we have obtained postmortem neuro-pathological confirmation of the diagnosis of dementia. In addition to data on cognition, we have also collected information on occupational history, medical history, medications and other lifetime experiences that may influence cognitive function in late life. We provide an overview of the study's methodology and describe the focus of recent research.

The National Academy of Sciences – National Research Council Veteran Twin Registry

1994 ◽  
Vol 43 (1-2) ◽  
pp. 89-94 ◽  
Author(s):  
M.M. Braun ◽  
R. Haupt ◽  
N.E. Caporaso
Keyword(s):  
Molecular Biology ◽  
Research Council ◽  
National Research Council ◽  
Twin Data ◽  
National Academy Of Sciences ◽  
Twin Registry ◽  
Recent Advances ◽  
History Of ◽  
The Creation ◽  
Academy Of Sciences

With recent advances in molecular biology and genetics, cohorts such as the National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry may become of increasing importance. This paper outlines the creation and history of the NAS-NRC Twin Registry, methodologies utilized for analysis of twin data, studies that have been completed or are underway, and possible future types of studies.

scholarly journals Cohort Profile: The National Academy of Sciences-National Research Council Twin Registry (NAS-NRC Twin Registry)

2014 ◽  
Vol 44 (3) ◽  
pp. 819-825 ◽  
Author(s):  
Margaret Gatz ◽  
Jennifer R Harris ◽  
Jaakko Kaprio ◽  
Matt McGue ◽  
Nicholas L Smith ◽  
...  
Keyword(s):  
Research Council ◽  
National Research Council ◽  
National Academy Of Sciences ◽  
Twin Registry ◽  
Academy Of Sciences

The Season of Birth of Schizophrenic, Neurotic and Psychiatrically Normal Twins

1982 ◽  
Vol 141 (2) ◽  
pp. 186-190 ◽  
Author(s):  
Kenneth S. Kendler
Keyword(s):  
Research Council ◽  
National Research Council ◽  
Twin Studies ◽  
Season Of Birth ◽  
Perinatal Complications ◽  
National Academy Of Sciences ◽  
Twin Registry ◽  
Increased Risk ◽  
Academy Of Sciences ◽  
Normal Twin

SummaryThe quarter of birth of 536 schizophrenic, 1,991 neurotic and 12,085 psychiatrically normal twin pairs from the National Academy of Sciences-National Research Council Twin Registry was compared. When either all twin pairs, or only monozygotic or dizygotic twin pairs, were considered, no significant differences were found in the quarter of birth between the 3 groups. No difference in quarter of birth was found for twin pairs concordant versus discordant for schizophrenia. Despite the increased risk for intrauterine and perinatal complications in twin births, schizophrenic twins appear (at least) to be no more vulnerable than schizophrenic singletons to the seasonal gestation and birth-related insults which probably underlie the seasonality in schizophrenic births. Controlling for season of birth probably has little effect on the results of twin studies of schizophrenia.

Sign in / Sign up

Export Citation Format

Share Document