scholarly journals The South Korean Twin Registry

2019 ◽  
Vol 22 (6) ◽  
pp. 606-608 ◽  
Author(s):  
Yoon-Mi Hur ◽  
Man Chull Kang ◽  
Hoe-Uk Jeong ◽  
Il Cook Kang ◽  
Jong Woo Kim
Keyword(s):  
Mental Health ◽  
Twin Studies ◽  
Developmental Differences ◽  
The South ◽  
South Korean ◽  
Twin Registry ◽  
Gene By Environment Interactions ◽  
Physical Traits ◽  
Genetic And Environmental Factors ◽  
Adult Twins

AbstractThe South Korean Twin Registry (SKTR) is an ongoing nationwide volunteer registry of South Korean twins and their families. Since its inception, from preschooler to young adult, twins have been registered with the SKTR and have demonstrated that relative influences of genetic and environmental factors explaining individual differences in various psychological, mental health and physical traits in South Koreans are similar to those found in many Western twin studies. Currently, studies at the SKTR focus on identification of the process of gene-by-environment interactions as well as developmental differences in genetic and environmental influences on psychological and mental health traits in South Koreans. This report provides a brief overview, recruitment strategies, current samples, zygosity assessment, measures and future directions of the SKTR.

The South Korean Twin Registry

2006 ◽  
Vol 9 (6) ◽  
pp. 838-843 ◽  
Author(s):  
Yoon-Mi Hur ◽  
Joong Sik Shin ◽  
Hoe-Uk Jeong ◽  
Jung Yeol Han
Keyword(s):  
Rural Areas ◽  
Target Population ◽  
Target Area ◽  
The South ◽  
Future Directions ◽  
South Korean ◽  
Disease Phenotypes ◽  
Twin Registry ◽  
History Of ◽  
Adult Twins

AbstractThe South Korean Twin Registry (SKTR), previously called the Seoul Twin Family Study, is a nationwide volunteer registry of South Korean twins and their families. Since 2002, the SKTR has been updated in 4 important ways. First, continued sampling led to an increase in the number of twins. Second, the target area, Seoul, was enlarged to include other cities and rural areas in the country. Third, the target population was extended from school-aged twins to preschool and adult twins. Fourth, the research focus was expanded to include psychiatric and physical disease phenotypes. The present article describes a brief history of the SKTR, goals and current research highlights, recent major accomplishments, and future directions.

scholarly journals The South Korean Twin Registry: An Update

2012 ◽  
Vol 16 (1) ◽  
pp. 237-240 ◽  
Author(s):  
Yoon-Mi Hur ◽  
Hoe-Uk Jeong ◽  
Kee Wha Chung ◽  
Joong Sik Shin ◽  
Tae-Bok Song
Keyword(s):  
Population Group ◽  
Group Differences ◽  
Parallel Study ◽  
The South ◽  
Psychological Traits ◽  
South Korean ◽  
Twin Registry ◽  
Physical Traits ◽  
Assessment Measures ◽  
Future Plans

The South Korean Twin Registry (SKTR) is an ongoing nation-wide volunteer registry of South Korean twins and their families, which was established in the year 2001 to understand genetic and environmental etiologies of psychological and physical traits among South Koreans. Recently, the SKTR sampling has been extended in two important ways. First, we began to recruit twins from lower socio-economic families to study interaction effects of gene by environmental context. Second, as a parallel study of the SKTR, the Nigerian Twin and Sibling Registry was developed to understand the origin of the population group differences/similarities in psychological traits between South Koreans and Nigerians. This article summarizes the main findings (based on the SKTR sample to date), recruitment procedures, zygosity assessment, measures, and future plans for the SKTR.

Update From Sri Lankan Twin Registry: Establishment of a Population-Based Twin Register and Ongoing Project on Common Mental Disorders, Alcohol Abuse and Suicidal Ideations

2006 ◽  
Vol 9 (6) ◽  
pp. 868-874 ◽  
Author(s):  
Sisira Hemananda Siribaddana ◽  
Waduthanthrige Danushki Siriwardane ◽  
Suwin Nilanga Hewage ◽  
Athukoralage Don Manjula Deshapriya Athukorale ◽  
Athula Sumathipala ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Common Mental Disorders ◽  
Twin Studies ◽  
Feasibility Studies ◽  
Population Based ◽  
Sri Lankan ◽  
Twin Registry ◽  
Electoral Register ◽  
Adult Twins ◽  
Ongoing Project

AbstractThe Sri Lankan Twin Registry began as a volunteer register in 1997. Previously, we have shown door-to-door surveys as the best option to build a population-based twin register of older, adult twins. Our aim was to build a population-based twin register in the Colombo district and use it for twin studies on common mental disorders. We aimed to identify a random sample of 4000 twins ascertained through the twin census. The Colombo district is divided into 13 divisional secretariat divisions (DSDs) and each division is further divided into Grama Niladari divisions administratively. Grama niladaris (GNs) are civil servants and visit each household in order to update the electoral register. GNs were used to do a census of twins while they updated the electoral register. The correlation between population density and twin rate among DSDs was .81, and between twin rate and the percentage of returned forms (from each DSD) was .74. We received 9648 forms notifying about twins and multiples. After removing the duplicates and information about twins who live in other districts, there were 17,406 multiples remaining. After incorporating twins and multiples from various other feasibility studies we now have 19,040 multiples with 8.46 twins per 1000 people in the Colombo district.

A Prospective Twin Registry in Southwestern China (TRiSC): Exploring the Effects of Genetic and Environmental Factors on Cognitive and Behavioral Development and Mental Health Wellbeing in Children and Adolescents

2009 ◽  
Vol 12 (3) ◽  
pp. 312-319 ◽  
Author(s):  
Yi Huang ◽  
David Collier ◽  
Tao Li
Keyword(s):  
Mental Health ◽  
Parenting Style ◽  
Cognitive Abilities ◽  
Behavioral Development ◽  
Southwestern China ◽  
Twin Registry ◽  
The Family ◽  
Self Reports ◽  
Genetic And Environmental Factors ◽  
Parental Health Status

AbstractThe goals, prospects and methods of the Prospective Twin Registry in Southwestern China (TRiSC) are described. The aim of this study is to measure children's behavioral development and psychopathology from phenotypic, genetic and environmental perspectives. It focuses on measuring children's behavior and psychopathology from child self-reports, as well as parental and teacher informant reports, and relating it to the children's general cognitive abilities, and to the parenting style in the family. Other variables of interest such as children's temperament and parental health status are discussed, as well as plans for further research.

scholarly journals The Brazilian Twin Registry

2016 ◽  
Vol 19 (6) ◽  
pp. 687-691 ◽  
Author(s):  
Paulo H. Ferreira ◽  
Vinicius C. Oliveira ◽  
Daniela R. Junqueira ◽  
Lígia C. Cisneros ◽  
Lucas C. Ferreira ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Twin Studies ◽  
Low Back ◽  
Media Campaigns ◽  
Health History ◽  
Twin Registry ◽  
Governmental Institutions ◽  
Genetic And Environmental Factors ◽  
The University ◽  
Different Sources

The Brazilian Twin Registry (BTR) was established in 2013 and has impelled twin research in South America. The main aim of the initiative was to create a resource that would be accessible to the Brazilian scientific community as well as international researchers interested in the investigation of the contribution of genetic and environmental factors in the development of common diseases, phenotypes, and human behavior traits. The BTR is a joint effort between academic and governmental institutions from Brazil and Australia. The collaboration includes the Federal University of Minas Gerais (UFMG) in Brazil, the University of Sydney and University of Melbourne in Australia, the Australian Twin Registry, as well as the research foundations CNPq and CAPES in Brazil. The BTR is a member of the International Network of Twin Registries. Recruitment strategies used to register twins have been through participation in a longitudinal study investigating genetic and environmental factors for low back pain occurrence, and from a variety of sources including media campaigns and social networking. Currently, 291 twins are registered in the BTR, with data on demographics, zygosity, anthropometrics, and health history having been collected from 151 twins using a standardized self-reported questionnaire. Future BTR plans include the registration of thousands of Brazilian twins identified from different sources and collaborate nationally and internationally with other research groups interested on twin studies.

scholarly journals Offspring ADHD as a Risk Factor for Parental Marital Problems: Controls for Genetic and Environmental Confounds

2012 ◽  
Vol 15 (6) ◽  
pp. 700-713 ◽  
Author(s):  
Alice C. Schermerhorn ◽  
Brian M. D'Onofrio ◽  
Wendy S. Slutske ◽  
Robert E. Emery ◽  
Eric Turkheimer ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Risk Factor ◽  
Marital Conflict ◽  
Parental Divorce ◽  
Marital Problems ◽  
Hyperactivity Disorder ◽  
Twin Registry ◽  
Genetic And Environmental Factors ◽  
Adult Twins ◽  
Discordant Twin

Background: Previous studies have found that child attention-deficit/hyperactivity disorder (ADHD) is associated with more parental marital problems. However, the reasons for this association are unclear. The association might be due to genetic or environmental confounds that contribute to both marital problems and ADHD. Method: Data were drawn from the Australian Twin Registry, including 1,296 individual twins, their spouses, and offspring. We studied adult twins who were discordant for offspring ADHD. Using a discordant twin pairs design, we examined the extent to which genetic and environmental confounds, as well as measured parental and offspring characteristics, explain the ADHD–marital problems association. Results: Offspring ADHD predicted parental divorce and marital conflict. The associations were also robust when comparing differentially exposed identical twins to control for unmeasured genetic and environmental factors, when controlling for measured maternal and paternal psychopathology, when restricting the sample based on timing of parental divorce and ADHD onset, and when controlling for other forms of offspring psychopathology. Each of these controls rules out alternative explanations for the association. Conclusion: The results of the current study converge with those of prior research in suggesting that factors directly associated with offspring ADHD increase parental marital problems.

scholarly journals University of Washington Twin Registry: Poised for the Next Generation of Twin Research

2012 ◽  
Vol 16 (1) ◽  
pp. 455-462 ◽  
Author(s):  
Eric Strachan ◽  
Corinne Hunt ◽  
Niloofar Afari ◽  
Glen Duncan ◽  
Carolyn Noonan ◽  
...  
Keyword(s):  
Twin Studies ◽  
Social Environments ◽  
Physical And Mental Health ◽  
University Of Washington ◽  
Geospatial Information ◽  
Twin Registry ◽  
Gene By Environment Interactions ◽  
Birth Records ◽  
New Research ◽  
The University

The University of Washington Twin Registry is a unique community-based registry of twin pairs who join specifically to participate in scientific research. It was founded in 2002 to serve as a resource for investigators throughout the scientific community. Current enrollment exceeds 7,200 pairs, and plans are in place to increase enrollment to 10,000 pairs by 2015. In addition to serving as a recruitment base for new research studies, the registry maintains extensive and continually expanding survey data on physical and mental health, as well as a biorepository that includes DNA from more than 8,800 individual twins. The registry is engaged in linking member data to birth records and to diagnostic and procedure variables for hospital-based care provided to members in Washington State. It also incorporates several innovative variables relevant to the built and social environments, which were created by geocoding twin addresses and linking the resulting coordinates to geospatial information systems databases. This combination of existing data and biospecimens, characterizing a group of twins who are willing to participate in research, is a valuable resource for the new wave of twin studies. These include ‘omics’, epigenetics, gene-by-environment interactions, and other novel methods to understand human health.

scholarly journals Heritability of Type 2 Diabetes in the Washington State Twin Registry

2019 ◽  
Vol 22 (2) ◽  
pp. 95-98 ◽  
Author(s):  
Ally R. Avery ◽  
Glen E. Duncan
Keyword(s):  
Type 2 Diabetes ◽  
Environmental Factors ◽  
Structural Equation ◽  
Genetic Factors ◽  
Washington State ◽  
Equation Modeling ◽  
Twin Registry ◽  
Genetic And Environmental Factors ◽  
Adult Twins

AbstractApproximately 12% of U.S. adults have type 2 diabetes (T2D). Diagnosed T2D is caused by a combination of genetic and environmental factors including age and lifestyle. In adults 45 years and older, the Discordant Twin (DISCOTWIN) consortium of twin registries from Europe and Australia showed a moderate-to-high contribution of genetic factors of T2D with a pooled heritability of 72%. The purpose of this study was to investigate the contributions of genetic and environmental factors of T2D in twins 45 years and older in a U.S. twin cohort (Washington State Twin Registry, WSTR) and compare the estimates to the DISCOTWIN consortium. We also compared these estimates with twins under the age of 45. Data were obtained from 2692 monozygotic (MZ) and same-sex dizygotic (DZ) twin pairs over 45 and 4217 twin pairs under 45 who responded to the question ‘Has a doctor ever diagnosed you with (type 2) diabetes?’ Twin similarity was analyzed using both tetrachoric correlations and structural equation modeling. Overall, 9.4% of MZ and 14.7% of DZ twins over the age of 45 were discordant for T2D in the WSTR, compared to 5.1% of MZ and 8% of DZ twins in the DISCOTWIN consortium. Unlike the DISCOTWIN consortium in which heritability was 72%, heritability was only 52% in the WSTR. In twins under the age of 45, heritability did not contribute to the variance in T2D. In a U.S. sample of adult twins, environmental factors appear to be increasingly important in the development of T2D.

Evidence for Nonadditive Genetic Effects on Eysenck Personality Scales in South Korean Twins

2007 ◽  
Vol 10 (2) ◽  
pp. 373-378 ◽  
Author(s):  
Yoon-Mi Hur
Keyword(s):  
Personality Traits ◽  
Model Fitting ◽  
Twin Studies ◽  
Mail Survey ◽  
Monozygotic Twin ◽  
Genetic Effects ◽  
Adolescent And Young Adult ◽  
The South ◽  
South Korean ◽  
Asian Populations

AbstractWhile evidence supporting for nonadditive genetic influences on personality traits in Caucasian populations has been growing in recent years, twin studies that explored the existence of genetic nonadditivity in personality variation in Asian populations are still lacking. Seven hundred and sixty-five pairs of adolescent and young adult twins registered with the South Korean Twin Registry completed the 7 scales of the Eysenck Personality Scales through a mail survey. Maximum likelihood twin correlations were computed and model-fitting analyses were conducted. Monozygotic twin correlations were consistently higher than twice the dizygotic twin correlations for all 7 scales, suggesting pervasive influences of nonadditive genetic effects on personality traits in the South Korean population. Model-fitting analyses indicated that genetic nonadditivity is particularly important for the variation of Impulsivity, Venturesomeness, Empathy, Lie, and Psychoticism. According to the best fitting models, nonadditive genetic effects ranged from 34 to 49% for these scales. For Neuroticism and Extraversion, models that included an additive genetic component fit better than those including a nonadditive genetic variance component.

scholarly journals The Qingdao Twin Registry: A Focus on Chronic Disease Research

2006 ◽  
Vol 9 (6) ◽  
pp. 758-762 ◽  
Author(s):  
Zengchang Pang ◽  
Feng Ning ◽  
Jennifer Unger ◽  
C. Anderson Johnson ◽  
Shaojie Wang ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Chronic Diseases ◽  
Twin Studies ◽  
Personality Factors ◽  
Behavioral Risk ◽  
Physical And Mental Health ◽  
Special Events ◽  
Twin Registry ◽  
Health Related ◽  
Adult Twins

AbstractWith the changing patterns of morbidity and mortality in China, noncommunicable chronic diseases have become the major threats to the health of the Chinese population. The causes of chronic diseases include genetic factors and behavioral risk factors such as the use of tobacco, alcohol, and other drugs, unhealthy dietary behaviors, and lack of physical activity. Twin studies offer a unique opportunity to disentangle the genetic and environmental risk and protective factors for chronic disease. The Qingdao Twin Registry (QTR) was initiated in 1998 as part of the National Chinese Twin Registry. Over 11,000 pairs of twins and multiples of all ages have been recruited into the registry. Several studies of physical and mental health are underway. Many of the adult twins have completed health and behavioral risk factor surveys, and the adolescent twins are participating in a study of gene–environment interactions in tobacco and alcohol use. Studies of the heritability of personality factors have been conducted. In 2002, Qingdao established the Qingdao Twin Health Promotion Association, a nonprofit organization that supports health services for twins and their parents, organizes special events and health-related activities for twins, and raises funds to conduct twin health examinations. The QTR will be a useful resource for future studies of population genetics in human health and disease.

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