Imaging and Cognitive Genetics: The Norwegian Cognitive NeuroGenetics Sample

2012 ◽  
Vol 15 (3) ◽  
pp. 442-452 ◽  
Author(s):  
Thomas Espeseth ◽  
Andrea Christoforou ◽  
Astri J. Lundervold ◽  
Vidar M. Steen ◽  
Stephanie Le Hellard ◽  
...  
Keyword(s):  
Sample Size ◽  
Cognitive Aging ◽  
Brain Function ◽  
Large Scale ◽  
Adult Life ◽  
Aging Brain ◽  
Adult Life Span ◽  
Cross Sectional ◽  
A Genome ◽  
Effects Of Aging

Data collection for the Norwegian Cognitive NeuroGenetics sample (NCNG) was initiated in 2003 with a research grant (to Ivar Reinvang) to study cognitive aging, brain function, and genetic risk factors. The original focus was on the effects of aging (from middle age and up) and candidate genes (e.g., APOE, CHRNA4) in cross-sectional and longitudinal designs, with the cognitive and MRI-based data primarily being used for this purpose. However, as the main topic of the project broadened from cognitive aging to imaging and cognitive genetics more generally, the sample size, age range of the participants, and scope of available phenotypes and genotypes, have developed beyond the initial project. In 2009, a genome-wide association (GWA) study was undertaken, and the NCNG proper was established to study the genetics of cognitive and brain function more comprehensively. The NCNG is now controlled by the NCNG Study Group, which consists of the present authors. Prominent features of the NCNG are the adult life-span coverage of healthy participants with high-dimensional imaging, and cognitive data from a genetically homogenous sample. Another unique property is the large-scale (sample size 300–700) use of experimental cognitive tasks focusing on attention and working memory. The NCNG data is now used in numerous ongoing GWA-based studies and has contributed to several international consortia on imaging and cognitive genetics. The objective of the following presentation is to give other researchers the information necessary to evaluate possible contributions from the NCNG to various multi-sample data analyses.

Contractile changes in opposing muscles of the human ankle joint with aging

1986 ◽  
Vol 61 (1) ◽  
pp. 361-367 ◽  
Author(s):  
A. A. Vandervoort ◽  
A. J. McComas
Keyword(s):  
Muscle Activation ◽  
Relaxation Times ◽  
Adult Life ◽  
The Elderly ◽  
Adult Life Span ◽  
Cross Sectional ◽  
Men And Women ◽  
Effects Of Aging ◽  
Voluntary Strength ◽  
Plantarflexor Muscles

The effects of aging on maximal voluntary strength and on the isometric twitch were determined in the ankle dorsiflexor and plantarflexor muscles of 111 healthy men and women aged 20–100 yr. Men were found to be stronger than women at all ages. In both sexes, the average values for maximum voluntary strength of the dorsiflexors and plantarflexors began to decline in the 6th decade. Although the absolute loss of strength was greater for the plantarflexor muscles, the relative losses were similar in the two muscle groups. During maximum voluntary effort, stimulation of motor nerves produced no additional torque in the majority of elderly men and women, indicating that these subjects remained able to utilize their descending motor pathways for optimal muscle activation. Comparisons of muscle compound action potentials, twitch torques, and muscle cross-sectional areas suggested that a decrease in excitable muscle mass was entirely responsible for the lower strength of the elderly. An additional effect of aging was the gradual prolongation of twitch contraction and half-relaxation times throughout the adult life-span.

Prevalence of Low Sexual Desire With Associated Distress Across the Adult Life Span: An Australian Cross-Sectional Study

2020 ◽  
Vol 17 (10) ◽  
pp. 1885-1895 ◽  
Author(s):  
Jia Zheng ◽  
Rakibul M. Islam ◽  
Robin J. Bell ◽  
Marina A. Skiba ◽  
Susan R. Davis
Keyword(s):  
Life Span ◽  
Sexual Desire ◽  
Adult Life ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Adult Life Span ◽  
Cross Sectional ◽  
Low Sexual Desire

Trait patterns of aquatic insects across gradients of flow-related factors: a multivariate analysis of Canadian national data

2008 ◽  
Vol 65 (4) ◽  
pp. 670-680 ◽  
Author(s):  
Nelli Horrigan ◽  
Donald J Baird
Keyword(s):  
Dissolved Oxygen ◽  
Large Scale ◽  
Aquatic Insect ◽  
Adult Life ◽  
Taxonomic Composition ◽  
Medium Size ◽  
Insect Communities ◽  
Related Factors ◽  
Adult Life Span ◽  
Consistent Manner

Large-scale comparisons of aquatic bioassessment metrics based on taxonomic composition are currently constrained by the biogeographic limitations of taxon occurrence. The use of species trait patterns offers a possibility to overcome this constraint. We examine the assertion that the trait composition of aquatic insect communities changes in a consistent manner along similar environmental disturbance gradients by evaluating relationships between traits and three flow-related variables (velocity, water temperature, and dissolved oxygen) in 13 independently collected Canadian data sets. Certain trait states such as low crawling rate, common occurrence in drift, short adult life span, erosional rheophily, medium size at maturity, and cold or cool thermal preference were consistently sensitive to all three flow-related factors, velocity in particular, despite biogeographic differences in faunal composition. Trait modalities exhibiting the highest mean correlation with velocity, temperature, and dissolved oxygen were identified, and the potential confounding effect of trait “syndromes” was addressed by restricting the selection of flow-sensitive traits to those with high evolutionary lability. The results of the study provide a basis for the future development of flow bioassessment metrics at the national Canadian scale and potentially at the international scale.

Cross-sectional analysis of pulsatile hemodynamics across the adult life span

2019 ◽  
Vol 37 (12) ◽  
pp. 2404-2413 ◽  
Author(s):  
Thomas Weber ◽  
Siegfried Wassertheurer ◽  
Bernhard Hametner ◽  
Susanne Moebus ◽  
Noreen Pundt ◽  
...  
Keyword(s):  
Life Span ◽  
Adult Life ◽  
Adult Life Span ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

scholarly journals Molecular identification of the swede midge (Diptera: Cecidomyiidae)

2004 ◽  
Vol 136 (6) ◽  
pp. 771-780 ◽  
Author(s):  
Juerg E. Frey ◽  
Beatrice Frey ◽  
Robert Baur
Keyword(s):  
Large Scale ◽  
Crop Protection ◽  
Adult Life ◽  
Molecular Diagnostic ◽  
Pest Species ◽  
Adult Life Span ◽  
Protection Measures ◽  
Major Pest ◽  
Swede Midge ◽  
Species Specific

AbstractEarly detection of pest infestation is a prerequisite for sustainable crop protection. However, many pest species are difficult to detect and thus infestation is diagnosed from damage observed on the respective crop. This diagnosis is often made too late for implementation of crop protection measures, and serious crop losses may result. The swede midge, Contarinia nasturtii Kieffer, is a major pest of Brassica L. (Brassicaceae) vegetables in Europe that has recently invaded North America. With its small size and short adult life-span, and the cryptic lifestyle of the larvae feeding at the growing points of its host plants, it is usually detected only after damage has already occurred. Furthermore, because field-trapped specimens are rarely fully intact, it is extremely difficult to identify. Therefore, we developed a species-specific molecular diagnostic method that enables reliable identification of swede midge from various sources such as alcohol or sticky glue traps. The method enables large-scale screening of field-trapped specimens and is used to evaluate the attractiveness and specificity of pheromone traps that are currently under development.

scholarly journals Age differences in the monitoring of learning: Cross-sectional evidence of spared resolution across the adult life span.

2010 ◽  
Vol 46 (4) ◽  
pp. 939-948 ◽  
Author(s):  
Christopher Hertzog ◽  
Starlette M. Sinclair ◽  
John Dunlosky
Keyword(s):  
Life Span ◽  
Age Differences ◽  
Adult Life ◽  
Adult Life Span ◽  
Cross Sectional

Curiosity and stimulation seeking across the adult life span: Cross-sectional and 6- to 8-year longitudinal findings.

1992 ◽  
Vol 7 (1) ◽  
pp. 150-157 ◽  
Author(s):  
Leonard M. Giambra ◽  
Cameron J. Camp ◽  
Alicia Grodsky
Keyword(s):  
Life Span ◽  
Adult Life ◽  
Adult Life Span ◽  
Cross Sectional
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