Contamination and effects of hydrocarbons on the Forth ecosystem, Scotland

1987 ◽  
Vol 93 (3-4) ◽  
pp. 327-342
Author(s):  
M. Elliott ◽  
A. H. Griffiths
Keyword(s):  
Deleterious Effect ◽  
Petrochemical Industry ◽  
Near Field ◽  
Toxic Effects ◽  
Organic Enrichment ◽  
Ecosystem Structure ◽  
Intertidal Habitat ◽  
Lethal Effects ◽  
Minimal Impact ◽  
History Of

SynopsisSince 1924 the Forth has received effluent from Scotland's major petrochemical industry and refinery in addition to hydrocarbon inputs from many other sources. The firth shows no major effects of this, but the history of inputs, together with the estuary's physical characteristics, have created a large residue of hydrocarbon contaminants especially in its sediments. This paper gives the degree and gradients of contamination in several components and describes the effect of hydrocarbon contaminants on the ecosystem structure.The major inputs have produced localised lethal effects, in that productive estuarine intertidal habitat has been lost or its functioning altered. The changes are primarily due to organic enrichment with only very near-field toxic effects. Some of the effects result from historical contamination, but existing discharges continue to have a deleterious effect. New petrochemical discharges in both firth and estuary appear to have a minimal impact, although the historical contamination makes it difficult to assess their effects.

Hypertension (HTN) in National Cancer Institute of Canada Clinical Trials Group study BR.24: A randomized, double-blind phase II trial of carboplatin (C) and paclitaxel (P) with either daily oral cediranib (CED), an inhibitor of vascular endothelial growth factor receptors, or placebo, in patients with advanced non-small cell lung cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 3527-3527
Author(s):  
R. A. Goodwin ◽  
L. Seymour ◽  
K. Ding ◽  
I. Gauthier ◽  
A. Le Maitre ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cox Regression ◽  
Treatment Algorithm ◽  
Progression Free Survival ◽  
Angiogenesis Inhibitors ◽  
Double Blind ◽  
Minimal Impact ◽  
Kaplan Meier ◽  
History Of ◽  
Baseline Characteristics

3527 Background: CED 30 mg/d with C+P increased response rate (RR: 38 vs 16% p < 0.0001) and median progression free survival (PFS: 5.6 vs 5 m, hazard ratio [HR] 0.77) over C+P alone. HTN is a known effect of angiogenesis inhibitors (AI). For BR.24, we describe the incidence of HTN, effects on drug delivery, predictors of its development/worsening, and assess the predictive effect of HTN on efficacy. Methods: Pts received C+P plus either placebo (n =146) or CED (n = 148). HTN as an adverse event (HTN AE: defined as either new onset HTN, or worsening grade HTN in a previously hypertensive pt), was managed with a protocol-defined algorithm. Exploratory analyses characterized the relationship between HTN AE and baseline characteristics and treatment arm. Kaplan Meier curves summarized time to event outcomes and Cox regression models with time dependent covariates correlated HTN AE to outcomes. Results: Rate of pts with a history of HTN were similar: CED 26 %, placebo 33 %. CED pts had significantly higher HTN AE (any: 38 vs 12%, p < 0.0001; grade 3 or 4: 19 vs 2 %). With the treatment algorithm, HTN AE had minimal impact on drug delivery (1 pt interrupted C+P, 11 pts [3.7%] reduced /discontinued CED / placebo). Headache was the only other AE that correlated with HTN AE. Predictors of HTN AE included: CED arm (p < 0.0001), good ECOG (p = 0.02), female (p = 0.006), history of HTN (p = 0.06). CED pts with HTN AE had significantly higher RR (51.8 vs 32.6%, p = 0.025) and PFS (8.5 vs 5.1 m; HR 0.45, 95% CI 0.29 to 0.72, p = 0.0007); similar but not significant findings were observed with placebo (RR 35.3 vs 17.2%, p= 0.098; PFS 5.6 vs 4.9 m; HR 0.84, 95 % CI 0.45–1.54); the interaction term by treatment arm was not significant. Conclusions: CED pts had greater HTN AE, but this did not impact drug delivery. Certain baseline characteristics predicted HTN AE in all pts. Unexpectedly, development of on-study HTN predicted improved outcome in all pts, although to a greater extent for those on CED. Additional evaluation of the role of HTN AE as a predictor of efficacy of both AI and cytotoxics is warranted. [Table: see text]

Indirect Effects of Pesticides on Mosquito Larvae Via Alterations of Community Structure

2010 ◽  
Vol 56 (3-4) ◽  
pp. 433-477 ◽  
Author(s):  
Sabine Duquesne ◽  
Matthias Liess
Keyword(s):  
Mosquito Control ◽  
Control Strategies ◽  
Parasitic Infection ◽  
Toxic Effects ◽  
Additional Stress ◽  
Biological Interactions ◽  
Lethal Effects ◽  
Positive Effects ◽  
Mediated Effects ◽  
Pesticide Treatment

We describe how pesticides used for mosquito control alter communities in mosquito breeding sites, and how these alterations affect larval populations of mosquitoes. Lethal and sublethal toxic effects modify biological interactions through density- and trait-mediated changes. Density-mediated effects due to pesticide treatment can lead to indirect positive effects on the target species. For example, recolonization of pests can be amplified due to disturbances of antagonistic species. Trait-mediated effects can result in lethal effects of originally sublethal exposure when the pesticide is combined with additional stress. Such lethal effects can result from changes of behavior or sensitivity. Also the immune capacity and resistance of individuals to parasitic infection could be decreased. Furthermore, pesticide treatment can act independently of toxic effects. For example, habitat and oviposition site selection can be influenced. These examples highlight the diversity of processes to be considered when determining the overall consequences of pesticide treatment. We show that a better understanding of these processes is needed to predict effects of pesticides on population dynamics. Such knowledge would have direct benefits in designing mosquito control strategies.

scholarly journals Rupture history of the 1997 Umbria-Marche (Central Italy) main shocks from the inversion of GPS, DInSAR and near field strong motion data

2009 ◽  
Vol 47 (4) ◽  
Author(s):  
B. Hernandez ◽  
M. Cocco ◽  
F. Cotton ◽  
S. Stramondo ◽  
O. Scotti ◽  
...  
Keyword(s):  
Near Field ◽  
Central Italy ◽  
Strong Motion ◽  
Strong Motion Data ◽  
Motion Data ◽  
Main Shocks ◽  
History Of

scholarly journals The Influence of Anticholinergic Drug and Oxime Selection on the Effectiveness of Antidotal Treatment Against Tabun-Induced Poisoning in Mice

2002 ◽  
Vol 45 (2) ◽  
pp. 75-78 ◽  
Author(s):  
Jiří Kassa
Keyword(s):  
Anticholinergic Drug ◽  
Lethal Dose ◽  
Acute Poisoning ◽  
Toxic Effects ◽  
Anticholinergic Drugs ◽  
Drug Selection ◽  
Lethal Effects ◽  
Hi 6 ◽  
The Difference ◽  
Acetylcholinesterase Reactivators

1. The influence of oximes (pralidoxime, obidoxime, HI-6) and anticholinergic drugs (atropine, benactyzine, biperiden, scopolamine) on the effectiveness of antidotal treatment to eliminate tabun-induced lethal effects was studied in mice. 2. Obidoxime seems to be the most efficacious oxime for the elimination of tabun-induced lethal effects in mice, although the difference in the efficacy of obidoxime and HI-6 is not significant when they are combined with atropine. 3. Obidoxime and HI-6 when combined with centrally acting anticholinergic drugs (benactyzine, biperiden and scopolamine) seem to be more efficacious in the elimination of toxic effects of the lethal dose of tabun than their combination with atropine. 4. The findings support the hypothesis that the choice of acetylcholinesterase reactivators as well as the anticholinergic drug selection are important for the effectiveness of antidotal mixture in the case of antidotal treatment of tabun-induced acute poisoning.

scholarly journals Assessment of the Therapeutic and Anticonvulsive Efficacy of a Drug Combination Consisting of Trihexyphenidyle and HI-6 in Soman-Poisoned Rats

2004 ◽  
Vol 47 (3) ◽  
pp. 171-175
Author(s):  
Jiří Kassa ◽  
Ivan Samnaliev
Keyword(s):  
Drug Combination ◽  
Anticholinergic Drug ◽  
Acute Poisoning ◽  
Toxic Effects ◽  
Anticholinergic Drugs ◽  
Lethal Effects ◽  
Hi 6 ◽  
Acute Toxic

1. The influence of two anticholinergic drugs (atropine, trihexyphenidyle) on the effectiveness of antidotal treatment to eliminate soman-induced lethal effects and convulsions was studied in rats. 2. The oxime HI-6 when combined with centrally acting anticholinergic drug trihexyphenidyle seems to be more efficacious in the elimination of acute toxic effects of soman than its combination with atropine. 3. The findings support the hypothesis that the choice of the anticholinergic drug is important for the effectiveness of antidotal mixture in the case of antidotal treatment of soman-induced acute poisoning.

scholarly journals DETECTION OF POTENTIALLY TOXIGENIC MICROCYSTIS STRAINS FROM DAU TIENG RESERVOIR

2018 ◽  
Vol 15 (4) ◽  
pp. 745-752
Author(s):  
Pham Thanh Luu ◽  
Ngo Xuan Quang
Keyword(s):  
Acute Toxicity ◽  
High Performance ◽  
Biological Effects ◽  
Dry Weight ◽  
Molecular Techniques ◽  
Toxic Effects ◽  
Public Water Supply ◽  
Aquatic Biota ◽  
Lethal Effects ◽  
Crude Extracts

Microcystis is a bloom-forming, common cyanobacterium in Dau Tieng reservoir used for public water supply. To assess the presence of potentially microcystin-producing Microcystis, molecular techniques were conducted and acute toxicity bioassays were performed with the microcrustacean Daphnia magna exposed to cyanobacterial crude extracts. Potentially toxigenic of isolated strains was characterized by amplifying mcyD genes and identification of Microcystis was confirmed by 16S rRNA amplification. Microcystins (MCs) concentration in bloom samples and cultured strains were quantified by High Performance Liquid Chromatography (HPLC). Results showed that there were 9/15 strains showed positive with the mcyD marker indicating that they are toxic strains. Three MCs variants including MC-RR, -LR and -YR were found in all extracts of toxic strains with the highest concentration of 1,218 μg/g dry weight (DW). The acute toxicity bioassays revealed that both toxic and non-toxic crude extracts elicited significant lethal effects on the tested animal with LC50 values ranged from 189-411 mg DW/L. The toxic effects of isolated strains were independent from the MCs concentration in some strains suggesting the presence of other metabolites contributed to the biological effects. In conclusion, microcystin-producing Microcystis from the Dau Tieng reservoir warn about possible toxic effects for aquatic biota and human health.

Mercury(I) chloride in vivo oxidation: a thermodynamic study

2015 ◽  
Vol 0 (0) ◽  
Author(s):  
Aliyar Mousavi
Keyword(s):  
Corrosive Sublimate ◽  
Thermodynamic Study ◽  
Toxic Effects ◽  
Medicinal Uses ◽  
History Of

AbstractMercury (Hg) has a long history of both medicinal uses and toxic effects. Hg chlorides were used as medicines; however, ‘corrosive sublimate’ (HgCl

scholarly journals ICES meets marine historical ecology: placing the history of fish and fisheries in current policy context

2015 ◽  
Vol 73 (5) ◽  
pp. 1386-1403 ◽  
Author(s):  
Georg H. Engelhard ◽  
Ruth H. Thurstan ◽  
Brian R. MacKenzie ◽  
Heidi K. Alleway ◽  
R. Colin A. Bannister ◽  
...  
Keyword(s):  
Case Studies ◽  
Science Policy ◽  
Historical Ecology ◽  
Reference Points ◽  
Ecosystem Structure ◽  
Habitat Integrity ◽  
Science Policy Interface ◽  
History Of ◽  
Ecosystem Changes ◽  
Marine Historical Ecology

Abstract As a discipline, marine historical ecology (MHE) has contributed significantly to our understanding of the past state of the marine environment when levels of human impact were often very different from those today. What is less widely known is that insights from MHE have made headway into being applied within the context of present-day and long-term management and policy. This study draws attention to the applied value of MHE. We demonstrate that a broad knowledge base exists with potential for management application and advice, including the development of baselines and reference levels. Using a number of case studies from around the world, we showcase the value of historical ecology in understanding change and emphasize how it either has already informed management or has the potential to do so soon. We discuss these case studies in a context of the science–policy interface around six themes that are frequently targeted by current marine and maritime policies: climate change, biodiversity conservation, ecosystem structure, habitat integrity, food security, and human governance. We encourage science–policy bodies to actively engage with contributions from MHE, as well-informed policy decisions need to be framed within the context of historical reference points and past resource or ecosystem changes.

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