Is strong reciprocity really strong in the lab, let alone in the real world?

2012 ◽  
Vol 35 (1) ◽  
pp. 29-29 ◽  
Author(s):  
Şule Güney ◽  
Ben R. Newell
Keyword(s):  
Real World ◽  
Evolutionary History ◽  
Real Life ◽  
Strong Reciprocity ◽  
The Real ◽  
Target Article ◽  
The Impact

AbstractWe argue that standard experiments supporting the existence of “strong reciprocity” do not represent many cooperative situations outside the laboratory. More representative experiments that incorporate “earned” rather than “windfall” wealth also do not provide evidence for the impact of strong reciprocity on cooperation in contemporary real-life situations or in evolutionary history, supporting the main conclusions of the target article.

PP469 From Theory To Practice: Which Value Framework Is Applied For Onco-Hematology Therapies In Italy? A 5-year Retrospective Analysis

2020 ◽  
Vol 36 (S1) ◽  
pp. 37-37
Author(s):  
Americo Cicchetti ◽  
Rossella Di Bidino ◽  
Entela Xoxi ◽  
Irene Luccarini ◽  
Alessia Brigido
Keyword(s):  
Real World ◽  
Ad Hoc ◽  
Grey Literature ◽  
National Level ◽  
Pharmaceutical Products ◽  
European Medicines Agency ◽  
The Real ◽  
R Process ◽  
The One ◽  
The Impact

IntroductionDifferent value frameworks (VFs) have been proposed in order to translate available evidence on risk-benefit profiles of new treatments into Pricing & Reimbursement (P&R) decisions. However limited evidence is available on the impact of their implementation. It's relevant to distinguish among VFs proposed by scientific societies and providers, which usually are applicable to all treatments, and VFs elaborated by regulatory agencies and health technology assessment (HTA), which focused on specific therapeutic areas. Such heterogeneity in VFs has significant implications in terms of value dimension considered and criteria adopted to define or support a price decision.MethodsA literature research was conducted to identify already proposed or adopted VF for onco-hematology treatments. Both scientific and grey literature were investigated. Then, an ad hoc data collection was conducted for multiple myeloma; breast, prostate and urothelial cancer; and Non Small Cell Lung Cancer (NSCLC) therapies. Pharmaceutical products authorized by European Medicines Agency from January 2014 till December 2019 were identified. Primary sources of data were European Public Assessment Reports and P&R decision taken by the Italian Medicines Agency (AIFA) till September 2019.ResultsThe analysis allowed to define a taxonomy to distinguish categories of VF relevant to onco-hematological treatments. We identified the “real-world” VF that emerged given past P&R decisions taken at the Italian level. Data was collected both for clinical and economical outcomes/indicators, as well as decisions taken on innovativeness of therapies. Relevant differences emerge between the real world value framework and the one that should be applied given the normative framework of the Italian Health System.ConclusionsThe value framework that emerged from the analysis addressed issues of specific aspects of onco-hematological treatments which emerged during an ad hoc analysis conducted on treatment authorized in the last 5 years. The perspective adopted to elaborate the VF was the one of an HTA agency responsible for P&R decisions at a national level. Furthermore, comparing a real-world value framework with the one based on the general criteria defined by the national legislation, our analysis allowed identification of the most critical point of the current national P&R process in terms ofsustainability of current and future therapies as advance therapies and agnostic-tumor therapies.

Evaluation of a calculation model to estimate the impact of the COVID-19 pandemic lockdown on visual acuity in neovascular AMD

2021 ◽  
pp. 112067212110523
Author(s):  
Martin Stattin ◽  
Anna-Maria Haas ◽  
Daniel Ahmed ◽  
Alexandra Graf ◽  
Katharina Krepler ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Real Life ◽  
Treatment Interruption ◽  
Term Treatment ◽  
Calculation Model ◽  
Life Outcomes ◽  
Short Term ◽  
Short Term Treatment ◽  
The Real ◽  
The Impact

Purpose A model was calculated during the first Austrian coronavirus disease-2019 (COVID-19) pandemic lockdown to estimate the effect of a short-term treatment interruption due to healthcare restrictions on visual acuity (VA) in neovascular age-related macular degeneration (nAMD). The model was compared to the real-life outcomes before treatment re-started. Methods Retrospective data-collection of 142 eyes in 142 patients receiving repeated intravitreal injections with anti-VEGF at a retina unit in Vienna in a personalized pro-re-nata regimen prior to the COVID-19 associated lockdown, when treatment was deferred between March 16 and May 4, 2020. During the lockdown, the preliminary data was integrated into pre-existing formulae based on the natural course of the disease in untreated eyes in the long term. Patients were re-scheduled and treated after gradually opening operating rooms. The calculation model was compared to the effective VA change. Results The model calculated an overall VA loss of 3.5 ± 0.8 letters early treatment diabetes retinopathy study (ETDRS) ( p < 0.001 [95% CI:3.3;3.6]) on average compared to 2.5 ± 6 letters ETDRS ( p < 0.001 [95% CI:1.5;3.5]) as measured with a mean treatment delay of 61 ± 14 days after previously scheduled appointments. The total difference between the model exercise and the real-life outcomes accounted for 1 ± 5.9 letters ETDRS ( p = 0.051 [95% CI: 0.1;1.9]). Conclusion The herein presented calculation model might not be suitable to estimate the effective VA loss correctly over time, although untreated eyes and eyes under therapy show similarities after short-term treatment interruption. However, this study demonstrated the potentially negative impact of the COVID-19 pandemic lockdown on patients compromised by nAMD.

scholarly journals From Literacy to Information Literacy: Reading for Understanding in the Real World

2021 ◽  
pp. 254-267
Author(s):  
John Royce
Keyword(s):  
Information Literacy ◽  
Real World ◽  
Real Life ◽  
The Internet ◽  
Good Readers ◽  
The Real ◽  
Life Problems ◽  
Complicated Process ◽  
Process Failure ◽  
Vital Component

Good readers evaluate as they go along, open to triggers and alarms which warn that something is not quite right, or that something has not been understood. Evaluation is a vital component of information literacy, a keystone for reading with understanding. It is also a complex, complicated process. Failure to evaluate well may prove expensive. The nature and amount of information on the Internet make evaluation skills ever more necessary. Looking at research studies in reading and in evaluation, real-life problems are suggested for teaching, modelling and discussion, to bring greater awareness to good, and to less good, readers.

scholarly journals Real-Life Continuous Flash Suppression - Rendering The Real World Unconscious Using Augmented Reality Goggles

2018 ◽  
Author(s):  
Uri Korisky ◽  
Rony Hirschhorn ◽  
Liad Mudrik
Keyword(s):  
Augmented Reality ◽  
Real World ◽  
Three Dimensional ◽  
Real Life ◽  
Continuous Flash Suppression ◽  
Future Studies ◽  
The Real ◽  
Dominant Eye ◽  
Novel Variant ◽  
Real Objects

Notice: a peer-reviewed version of this preprint has been published in Behavior Research Methods and is available freely at http://link.springer.com/article/10.3758/s13428-018-1162-0Continuous Flash Suppression (CFS) is a popular method for suppressing visual stimuli from awareness for relatively long periods. Thus far, it has only been used for suppressing two-dimensional images presented on-screen. We present a novel variant of CFS, termed ‘real-life CFS’, with which the actual immediate surroundings of an observer – including three-dimensional, real life objects – can be rendered unconscious. Real-life CFS uses augmented reality goggles to present subjects with CFS masks to their dominant eye, leaving their non-dominant eye exposed to the real world. In three experiments we demonstrate that real objects can indeed be suppressed from awareness using real-life CFS, and that duration suppression is comparable that obtained using the classic, on-screen CFS. We further provide an example for an experimental code, which can be modified for future studies using ‘real-life CFS’. This opens the gate for new questions in the study of consciousness and its functions.

scholarly journals The Promise of Creativity

2012 ◽  
Vol 6 (1) ◽  
pp. 389-407 ◽  
Author(s):  
Maxine E. Sprague ◽  
Jim Parsons
Keyword(s):  
Real World ◽  
Teaching And Learning ◽  
The Body ◽  
The Real ◽  
Digital World ◽  
Body Of Knowledge ◽  
Imaginative Play ◽  
A Priority ◽  
The Impact

In this paper, the authors discuss creativity and the impact it might have on teaching and learning. The authors believe that imaginative play, at all ages, helps all people (children especially) create healthy environments and spaces that expand their learning. The authors contend that teaching for imagination—which asks little more than creating and trusting an ecological space that engenders it—seldom is considered a priority. Given the emphasis on creativity in the real world and the virtual digital world, the authors believe it is important to add to the body of knowledge through continued research in this field.

scholarly journals A Novel Method based on Gaussianity and Sparsity for Signal Separation Algorithms

2017 ◽  
Vol 7 (4) ◽  
pp. 1906 ◽  
Author(s):  
Abouzid Houda ◽  
Chakkor Otman
Keyword(s):  
Independent Component Analysis ◽  
Blind Source Separation ◽  
Real World ◽  
Source Separation ◽  
Real Life ◽  
Signal Separation ◽  
Mixing Process ◽  
The Real ◽  
Input Signals ◽  
Novel Method

Blind source separation is a very known problem which refers to finding the original sources without the aid of information about the nature of the sources and the mixing process, to solve this kind of problem having only the mixtures, it is almost impossible , that why using some assumptions is needed in somehow according to the differents situations existing in the real world, for exemple, in laboratory condition, most of tested algorithms works very fine and having good performence because the  nature and the number of the input signals are almost known apriori and then the mixing process is well determined for the separation operation.  But in fact, the real-life scenario is much more different and of course the problem is becoming much more complicated due to the the fact of having the most of the parameters of the linear equation are unknown. In this paper, we present a novel method based on Gaussianity and Sparsity for signal separation algorithms where independent component analysis will be used. The Sparsity as a preprocessing step, then, as a final step, the Gaussianity based source separation block has been used to estimate the original sources. To validate our proposed method, the FPICA algorithm based on BSS technique has been used.

scholarly journals Flawed Model Misrepresents the Impact of Anesthesiologists to Patient Safety in the Real World

2012 ◽  
Vol 117 (2) ◽  
pp. 437-438
Author(s):  
Jerry A. Cohen ◽  
Norman A. Cohen ◽  
James D. Grant ◽  
Daniel J. Cole
Keyword(s):  
Patient Safety ◽  
Real World ◽  
The Real ◽  
The Impact

scholarly journals Social Skills Amongst MMORPG-Gamers: Empirical Study

2018 ◽  
Vol 50 ◽  
pp. 01008 ◽  
Author(s):  
Olga Sergeyeva ◽  
Anna Tsareva ◽  
Nadezhda Zinoveva ◽  
Olga Kononova
Keyword(s):  
Computer Games ◽  
Interpersonal Relations ◽  
Real Life ◽  
Point Of View ◽  
Ordinary People ◽  
Social Culture ◽  
The Real ◽  
New Ideas ◽  
The Impact ◽  
Social Interaction Skills

The research paper addresses the issue of the impact of MMORPGs on social culture and communication skills of individuals. The mainstream discourse about computer games which take individuals away from reality and substitute the real life by the fictional one is complemented by brand new ideas, which affirm that computer games do not substitute but supplement the real life and expand its possibilities. To confirm the presented point of view we use diagnostic questionnaire of interpersonal relations by A.A. Rukavishnikov. This questionnaire is aimed to evaluate typical ways of respondent’s attitude towards other people. At this point we have 43 gamers and 29 non-gamers involved in our research, aged 18 to 57. The comparison of a user and non-user answers gives a bigger view on an overall gaming experience. In the obtained indices we note that there are no fundamental differences between MMORPGs gamers and ordinary people. During research, MMORPGs users have showed many important social interaction skills such as striving to control own actions, collaborate with others, though with a low interest in emotionally charged relationships. Authors discuss the idea about the differences between addiction and fascination among gamers.

scholarly journals Making Science Fiction Real: Neoliberalism, Real-Life and Esports in Eve Online

2018 ◽  
Vol 10 (3) ◽  
Author(s):  
Mark Richard Johnson ◽  
Robert Mejia
Keyword(s):  
Science Fiction ◽  
Virtual Worlds ◽  
Real World ◽  
Free Market ◽  
Real Life ◽  
Physical World ◽  
The Real ◽  
Contemporary World ◽  
Neoliberal Capitalism ◽  
Political Economic

In this paper, we argue that EVE Online is a fruitful site for exploring how the representational and political-economic elements of science fiction intersect to exert a sociocultural and political-economic force on the shape and nature of the future-present. EVE has been oft heralded for its economic and sociocultural complexity, and for employing a free market ethos and ethics in its game world. However, we by contrast seek not to consider how EVE reflects our contemporary world, but rather how our contemporary neoliberal milieu reflects EVE. We explore how EVE works to make its world of neoliberal markets and borderline anarcho-capitalism manifest through the political economic and sociocultural assemblages mobilized beyond the game. We explore the deep intertwining of  behaviors of players both within and outside of the game, demonstrating that EVE promotes neoliberal  activity in its players, encourages these behaviors outside the game, and that players who have found success in the real world of neoliberal capitalism are those best-positioned for success in the time-demanding and resource-demanding world of EVE. This thereby sets up a reciprocal ideological determination between the real and virtual worlds of EVE players, whereby each reinforces the other. We lastly consider the “Alliance Tournament” event, which romanticizes conflict and competition, and argue that it serves as a crucial site for deploying a further set of similar rhetorical resources. The paper therefore offers an understanding of the sociocultural and political-economic pressure exerted on the “physical” world by the intersection of EVE’s representational and material elements, and what these show us about the real-world ideological power of science fictional worlds.

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