Serum total oxidant and antioxidant status in earthquake survivors with post-traumatic stress disorder

2015 ◽  
Vol 27 (3) ◽  
pp. 153-158 ◽  
Author(s):  
Pinar Guzel Ozdemir ◽  
İbrahim Kaplan ◽  
Cem Uysal ◽  
Mahmut Bulut ◽  
Abdullah Atli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Antioxidant Status ◽  
Stress Disorder ◽  
Total Antioxidant Status ◽  
Post Traumatic Stress ◽  
Total Antioxidant ◽  
Post Traumatic ◽  
Earthquake Survivors

ObjectiveOxidative stress has been shown to play an important role in the pathogenesis of post-traumatic stress disorder (PTSD). Although there are some studies on oxidative stress and PTSD, there is no report available on the serum total oxidant and antioxidant status in earthquake survivors with PTSD. Therefore, this study aimed to investigate the serum total oxidant and antioxidant status in earthquake survivors with chronic PTSD.Material and MethodsThe study group included 45 earthquake survivors with PTSD and 40 earthquake survivors without PTSD. The oxidative status was determined using the total antioxidant status and total oxidant status (TOS) measurements and by calculating the oxidative stress index (OSI).ResultsThere were no statistically significant differences in the total antioxidant status, TOS, or OSI when comparing individuals with and without PTSD (all,p>0.05). There were no correlations between Clinician-Administered PTSD Scale scores and oxidant and antioxidant stress markers (all,p>0.05).ConclusionsOur results suggest that the total oxidant and antioxidant status may not affect earthquake survivors with PTSD. This is the first study to evaluate the oxidative status in earthquake survivors with PTSD. Further studies are necessary to confirm these findings.

Plasma brain-derived neurotrophic factor in earthquake survivors with full and partial post-traumatic stress disorder

2013 ◽  
Vol 67 (5) ◽  
pp. 363-364 ◽  
Author(s):  
Paolo Stratta ◽  
Roberto L. Bonanni ◽  
Patrizia Sanità ◽  
Stefano de Cataldo ◽  
Adriano Angelucci ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Neurotrophic Factor ◽  
Stress Disorder ◽  
Brain Derived Neurotrophic Factor ◽  
Post Traumatic Stress ◽  
Post Traumatic ◽  
Earthquake Survivors

L-Carnitine prevents memory impairment induced by post-traumatic stress disorder

2021 ◽  
pp. 1-9
Author(s):  
Karem H. Alzoubi ◽  
Arwa M. Al-Dekah ◽  
Saied Jaradat ◽  
Nasr Alrabadi
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Memory Impairment ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Short And Long Term ◽  
Post Traumatic

Background: Post-traumatic stress disorder (PTSD) is a genuine obstructing mental disorder. As indicated by the name, it is related to the patients’ stress augmented by life-threatening conditions or accidents. The PTSD has linked to oxidative stress that can result in neurodegeneration. L-carnitine (L-CAR) is known for its antioxidant properties, which can protect against neuronal damage. Objective: In the current study, we investigated the beneficial effects of L-CAR on the memory impairment induced by PTSD using a rat model. Methods: A model of single-prolonged stress (a cycle of restraining, forced swimming, rest, and finally diethyl ether exposure for 2 h, 20 min, 15 min, and 1–2 min, respectively) was used to induce PTSD-like behavior. Intraperitoneal L-CAR treatment (300 mg/kg/day) was introduced for four weeks. Both memory and special learning were evaluated utilizing the radial arm water maze (RAWM). Moreover, the levels of glutathione peroxidase (GPx), glutathione reduced (GSH), and glutathione oxidized (GSSG) were assessed as biomarkers oxidative stress in the hippocampus. Results: The results demonstrated that both the short and long-term memories were impaired by PTSD/SPS model (P <  0.05), while L-CAR treatment prevented this memory impairment in PTSD rats. Besides, L-CAR prevented the reduction in GPx activity and increase in GSSG, which were altered in the hippocampus of the PTSD/SPS rats (P <  0.05). Levels of GSH were not changed in PTSD and/or L-CAR rats. Conclusions: L-CAR administration prevented short- and long-term memories’ impairments induced in the PTSD/SPS rat model. This is probably related to its antioxidant effects in the hippocampus.

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