Aspects of metabolic changes in first-episode drug-naïve schizophrenic patients

2013 ◽  
Vol 25 (5) ◽  
pp. 268-274 ◽  
Author(s):  
Marat G. Uzbekov ◽  
Eduard Misionzhnik ◽  
Isaak Gurovich ◽  
Alexander Shmukler ◽  
Tatjana Moskvitina
Keyword(s):  
Amine Oxidase ◽  
Initial Step ◽  
Chronic Schizophrenia ◽  
First Episode ◽  
Pathological State ◽  
Biochemical Status ◽  
Syndrome Scale ◽  
Schizophrenic Patients ◽  
Drug Naïve ◽  
Relationship Of

AimThe aim of the study was to investigate the state of parameters characterising different sites of metabolism and the degree of endogenous intoxication in first-episode drug-naïve schizophrenic [first episode of schizophrenia (FES)] patients. It is hypothesised that the FES is the initial step in the development of pathologically disturbed biochemical status that is characteristic of chronic schizophrenia.MethodsPlatelet monoamine oxidase (MAO) and serum semicarbazide-sensitive amine oxidase (SSAO) activities, serum concentrations of middle-mass endotoxic molecules (MMEM) and malondialdehyde and parameters of the serum albumin functional state were measured in 26 FES patients and 15 age-matched healthy controls.ResultsSeverity of disorder before the treatment was 75.5 ± 2.2, according to Positive and Negative Syndrome Scale score. FES patients were characterised by significant increase in MAO activity (99%) and MMEM concentration (124%) and significant decrease in SSAO activity (26%) as compared with controls. Changes of all other parameters were insignificant. Regression analysis has showed a significant relationship of three parameters – MAO, SSAO and MMEM, with values of PANNS score. Two methods of extraction of factor analysis revealed that MAO and SSAO belonged to Factor 1, whereas MMEM and albumin functional parameters belonged to Factor 2.ConclusionComparing our earlier data on chronic schizophrenic patients with present data, we hypothesise that FES patients are at the stage that leads to a stable, pathological state of metabolism.

scholarly journals Peculiarities of Biochemical Changes in the First-episode Drug Naïve Schizophrenic Patients

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
M. Uzbekov ◽  
E. Misionzhnik ◽  
I. Gurovich ◽  
A. Shmukler
Keyword(s):  
Amine Oxidase ◽  
First Episode ◽  
Pathological State ◽  
Serum Concentrations ◽  
Endogenous Intoxication ◽  
Schizophrenic Patients ◽  
Mao Activity ◽  
Drug Naïve ◽  
Platelet Monoamine Oxidase ◽  
Relationship Of

Aim:The aim of the study was to investigate the state of parameters characterizing different sites of metabolism and the degree of endogenous intoxication in drug-naïve first episode schizophrenic patients (FES).Methods:Platelet monoamine oxidase (MAO) and serum semicarbazide-sensitive amine oxidase (SSAO) activities, serum concentrations of middle-mass endotoxic molecules (MMEM) and malondialdehyde and parameters of serum albumin functional state (Uzbekov et al., 2006) were measured in 16 FES patients and 15 age-matched healthy volunteers.Results:Severity of disorder prior the treatment was 73.1±12.5 according to PANSS score. FES patients were characterized by significant increase in MAO activity (by 107 %) and MMEM concentration (by 140 %) and significant decrease in SSAO activity (by 29 %) as compared with controls. Degree of endogenous intoxication in 13 patients was assessed as moderate and severe. Changes of all other parameters were insignificant. Regression analysis has shown significant relationship of 3 parameters - MAO (p< 0,01), SSAO (p< 0,01) and MMEM (p< 0,02) with values of PANNS score. Three methods of extraction of factor analysis have revealed that MAO and SSAO are belonged to factor 1 whereas MMEM and albumin functional parameters - to factor 2.Conclusions:It is supposed that MAO and SSAO are integral components of schizophrenia pathogenetic mechanisms. Comparing our earlier data on chronic schizophrenic patients with these data we suppose that FES patients are on the stage of the formation of the pathological state of metabolism.Study was partially supported by the ISTC grant 3156.

Differential sensory gating functions between smokers and non-smokers among drug-naive first episode schizophrenic patients

2011 ◽  
Vol 188 (3) ◽  
pp. 327-333 ◽  
Author(s):  
Xing-shi Chen ◽  
Chun-bo Li ◽  
Robert C. Smith ◽  
Ze-ping Xiao ◽  
Ji-jun Wang
Keyword(s):  
Sensory Gating ◽  
First Episode ◽  
Schizophrenic Patients ◽  
Drug Naïve

scholarly journals Abnormalities of EEG Microstates In Drug-Naïve, First-Episode Schizophrenia

2021 ◽  
Author(s):  
Qiaoling Sun ◽  
Linlin Zhao ◽  
Liwen Tan
Keyword(s):  
Clinical Symptoms ◽  
Early Stage ◽  
First Episode ◽  
Healthy Controls ◽  
Brain Functions ◽  
Class D ◽  
Syndrome Scale ◽  
Drug Naïve ◽  
Microstate Analysis ◽  
First Episode Schizophrenia

Abstract Objective: Microstate analysis is a powerful tool to probe the brain functions, and changes in microstates under electroencephalography (EEG) have been repeatedly reported in patients with schizophrenia. This study aimed to investigate the dynamics of EEG microstates in drug-naïve, first-episode schizophrenia (FE-SCH) and to test the relationship between EEG microstates and clinical symptoms.Methods: Resting-state EEG were recorded for 23 patients with FE-SCH and 23 healthy controls using a 64-channel cap. Three parameters, i.e., contribution, duration, and occurrence, of the four microstate classes were calculated. Group differences in EEG microstates and their clinical symptoms (assessed using the Positive and Negative Syndrome Scale) were analyzed.Results: Compared with healthy controls, patients with FE-SCH showed increased duration, occurrence and contribution of microstate class C and decreased contribution and occurrence of microstate class D. In addition, the score of positive symptoms in PANSS was negatively correlated with the occurrence of microstate D.Conclusions: Our findings showed abnormal patterns of EEG microstates in drug-naïve, first-episode schizophrenia, which might help distinguish individuals with schizophrenia in the early stage and develop early intervention strategies.

scholarly journals The striatal dopamine transporter in first-episode, drug-naive schizophrenic patients: evaluation by the new SPECT-ligand[99mTc]TRODAT-1

2005 ◽  
Vol 19 (5) ◽  
pp. 488-493 ◽  
Author(s):  
G. J. E Schmitt ◽  
E. M. Meisenzahl ◽  
T. Frodl ◽  
C. La Fougère ◽  
K. Hahn ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Striatal Dopamine ◽  
First Episode ◽  
Schizophrenic Patients ◽  
Drug Naïve

Late Onset Involuntary Movements in Chronic Schizophrenia: Relationship of ‘Tardive’ Dyskinesia to Intellectual Impairment and Negative Symptoms

1986 ◽  
Vol 149 (5) ◽  
pp. 616-620 ◽  
Author(s):  
J. L. Waddington ◽  
H. A. Youssef
Keyword(s):  
Tardive Dyskinesia ◽  
Negative Symptoms ◽  
Late Onset ◽  
Chronic Schizophrenia ◽  
Intellectual Impairment ◽  
Medication History ◽  
Involuntary Movements ◽  
Schizophrenic Patients ◽  
Relationship Of

Intellectual impairment, negative symptoms, and medication history were assessed in chronic schizophrenic patients with and without abnormal involuntary movements (tardive dyskinesia). Patients with involuntary movements had received neither longer nor more intensive treatment with neuroleptics or anticholinergics. However, the presence or absence of involuntary movements was prominently associated with the presence or absence of intellectual impairment/negative symptoms; these features are characteristic of the defect state/type II syndrome of schizophrenia, in which structural abnormalities of the brain may be over-represented. The role of subtle organic changes in conferring vulnerability to the emergence of such involuntary movements should be re-evaluated.

scholarly journals Cingulate Abnormalities Associated with PANSS Negative Scores in First Episode Schizophrenia

2000 ◽  
Vol 12 (1-2) ◽  
pp. 93-101 ◽  
Author(s):  
Liz Ashton ◽  
Anna Barnes ◽  
Martin Livingston ◽  
David Wyper ◽  
The Scottish Schizophrenia Research Group
Keyword(s):  
Negative Symptoms ◽  
Statistical Parametric Mapping ◽  
Biological Marker ◽  
Anterior Cingulate ◽  
First Episode ◽  
Cingulate Gyrus ◽  
Regional Cerebral Blood ◽  
Schizophrenic Patients ◽  
Drug Naïve ◽  
First Episode Schizophrenia

There is evidence for the involvement of the cingulate gyrus in schizophrenia. We present details of a Statistical Parametric Mapping (SPM) analysis of SPECT data from the largest study (N= 39) of drug naive schizophrenic patients. The main findings are that there is decreased perfusion in the anterior cingulate during verbal fluency when patients are compared to controls (matched individually by age, gender and father’s social class as determined by occupation) and also that PANSS negative scores correlate negatively with regional cerebral blood flow in the cingulate gyrus (Pearson’s Correlation coefficient ofr= − 0.49 and significancep< 0.005). This suggests that measurement of change of perfusion in this region could be a useful biological marker in assessing the effect of neuroleptics on negative symptoms.

Conformational and Functional Disturbances of Serum Albumin Are Characteristic for First Episode Drug-naive Schizophrenic Patients.

2015 ◽  
Vol 30 ◽  
pp. 915
Author(s):  
M. Uzbekov ◽  
T. Syrejshchikova ◽  
T. Babushkina ◽  
N. Smolina ◽  
V. Kalinina ◽  
...  
Keyword(s):  
Serum Albumin ◽  
First Episode ◽  
Functional Disturbances ◽  
Schizophrenic Patients ◽  
Drug Naïve

P.5.020 Patterns of drug consumption in first-episode drug-naive schizophrenic patients

2003 ◽  
Vol 13 ◽  
pp. S416
Author(s):  
L. San ◽  
B. Arranz ◽  
N. Ramirez ◽  
R. Dueñas ◽  
J.M. Sanchez ◽  
...  
Keyword(s):  
Drug Consumption ◽  
First Episode ◽  
Schizophrenic Patients ◽  
Drug Naïve

The Study of the Antisaccade Performance and Contingent Negative Variation Characteristics in First-Episode and Chronic Schizophrenia Patients

2017 ◽  
Vol 20 ◽  
Author(s):  
Anna V. Kirenskaya ◽  
Andrej A. Tkachenco ◽  
Vladimir Yu. Novototsky-Vlasov
Keyword(s):  
Effect Size ◽  
Contingent Negative Variation ◽  
Chronic Schizophrenia ◽  
First Episode ◽  
Chronic Patients ◽  
Duration Of Illness ◽  
Latency Variability ◽  
Variation Characteristics ◽  
Schizophrenic Patients ◽  
Functional Deterioration

AbstractThe study tested whether the antisaccade (AS) performance and Contingent Negative Variation (CNV) measures differed between the first-episode and chronic patients to provide the evidence of PFC progressive functional deterioration. Subjects included 15 first-episode and 20 chronic schizophrenic patients (with the duration of illness more than 5 years), and 21 control subjects. The first-episode and chronic patients had significantly elevated error percent (p < .05, effect size 1.10 and p < .001, effect size 1.25), increased AS latencies (p < .01, effect size 1.18 and p < .001, effect size 1.69), and increased latencies variability (p < .01, effect size 1.52 and p < .001, effect size 1.37) compared to controls. Chronic patients had marginally significant increase of the response latency (p = .086, effect size .78) and latency variability (p < .099, effect size .63) compared to first-episode ones. Results of CNV analysis revealed that chronic patients only exhibited robustly declined frontal CNV amplitude at Fz (p < .05, effect size .70), F3 (p < .05, effect size .88), and F4 (p < .05, effect size .71) sites compared to controls. The obtained results might be related to specific changes in prefrontal cortex function over the course of schizophrenia.

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