scholarly journals Three Approaches to Design Engineering in the Health Domain: A Systemic Perspective

2019 ◽  
Vol 1 (1) ◽  
pp. 1005-1014 ◽  
Author(s):  
Valeria Pannunzio ◽  
Maaike Kleinsmann ◽  
Dirk Snelders
Keyword(s):  
Engineering Design ◽  
Health Systems ◽  
Systems Thinking ◽  
Design Approach ◽  
Future Research ◽  
Design Engineering ◽  
Health Domain ◽  
Advantages And Disadvantages ◽  
Societal Challenges ◽  
Methodological Challenges

AbstractThis paper proposes a categorization of existing approaches to healthcare-related engineering design based on systems thinking principles. Three existing approaches to healthcare-related engineering design are isolated which contribute differently to health systems fundamental purposes and interconnections. The three approaches are labeled as 'silent', 'overt', and 'convergent' health design. Each approach is defined and illustrated through an example. Following, practical advantages and disadvantages of each approach are discussed. A reflection is offered on the expected relevance of the convergent health design approach for present and future societal challenges in the health domain, and specifically on the recently growing field of e-health. Finally, open methodological challenges related to convergent health design are outlined and characterized as opportunities for future research.

A Review of Drug Side Effect Identification Methods

2020 ◽  
Vol 26 (26) ◽  
pp. 3096-3104 ◽  
Author(s):  
Shuai Deng ◽  
Yige Sun ◽  
Tianyi Zhao ◽  
Yang Hu ◽  
Tianyi Zang
Keyword(s):  
Side Effects ◽  
Future Research ◽  
Drug Side Effects ◽  
Important Indicator ◽  
Advantages And Disadvantages ◽  
Key Points ◽  
Network Methods ◽  
Future Research Directions ◽  
The One ◽  
Approved Drugs

Drug side effects have become an important indicator for evaluating the safety of drugs. There are two main factors in the frequent occurrence of drug safety problems; on the one hand, the clinical understanding of drug side effects is insufficient, leading to frequent adverse drug reactions, while on the other hand, due to the long-term period and complexity of clinical trials, side effects of approved drugs on the market cannot be reported in a timely manner. Therefore, many researchers have focused on developing methods to identify drug side effects. In this review, we summarize the methods of identifying drug side effects and common databases in this field. We classified methods of identifying side effects into four categories: biological experimental, machine learning, text mining and network methods. We point out the key points of each kind of method. In addition, we also explain the advantages and disadvantages of each method. Finally, we propose future research directions.

scholarly journals A Review of Dynamic Balancing for Robotic Mechanisms

Robotica ◽  
2020 ◽  
Vol 39 (1) ◽  
pp. 55-71 ◽  
Author(s):  
Bin Wei ◽  
Dan Zhang
Keyword(s):  
Future Research ◽  
Dynamic Balancing ◽  
Advantages And Disadvantages

SUMMARYThe authors summarize the main dynamic balancing methods of robotic mechanisms in this paper. The majority of dynamic balancing methods have been presented, and there may be other dynamic balancing methods that are not included in this paper. Each of the balancing methods is reviewed and discussed. The advantages and disadvantages of each method are presented and compared. The goal of this paper is to provide an overview of recent research in balancing. The authors hope that this study can provide an informative reference for future research in the direction of dynamic balancing of robotic mechanisms.

scholarly journals Validity of the Gender Dysphoria diagnosis and incidence trends in Sweden: a nationwide register study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Malin Indremo ◽  
Richard White ◽  
Thomas Frisell ◽  
Sven Cnattingius ◽  
Alkistis Skalkidou ◽  
...  
Keyword(s):  
Gender Dysphoria ◽  
Age Groups ◽  
Medical Intervention ◽  
Future Research ◽  
Advantages And Disadvantages ◽  
Incidence Trends ◽  
Interaction Terms ◽  
Definition Of ◽  
The Individual ◽  
Nationwide Register Study

AbstractThe aim of this study was to examine the validity of the Gender Dysphoria (GD) diagnoses in the Swedish National Patient Register (NPR), to discuss different register-based definitions of GD and to investigate incidence trends. We collected data on all individuals with registered GD diagnoses between 2001 and 2016 as well as data on the coverage in the NPR. We regarded gender confirming medical intervention (GCMI) as one proxy for a clinically valid diagnosis and calculated the positive predictive value (PPV) for receiving GCMI for increasing number of registered GD diagnoses. We assessed crude and coverage-adjusted time trends of GD during 2004–2015 with a Poisson regression, using assigned sex and age as interaction terms. The PPV for receiving GCMI was 68% for ≥ 1 and 79% for ≥ 4 GD-diagnoses. The incidence of GD was on average 35% higher with the definition of ≥ 1 compared to the definition of ≥ 4 diagnoses. The incidence of GD, defined as ≥ 4 diagnoses increased significantly during the study period and mostly in the age categories 10–17 and 18–30 years, even after adjusting for register coverage. We concluded that the validity of a single ICD code denoting clinical GD in the Swedish NPR can be questioned. For future research, we propose to carefully weight the advantages and disadvantages of different register-based definitions according to the individual study’s needs, the time periods involved and the age-groups under study.

scholarly journals Involvement of Probiotics and Postbiotics in the Immune System Modulation

Biologics ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 89-110
Author(s):  
Neslihan Yeşilyurt ◽  
Birsen Yılmaz ◽  
Duygu Ağagündüz ◽  
Raffaele Capasso
Keyword(s):  
Immune System ◽  
Pharmaceutical Industry ◽  
Intestinal Microbiota ◽  
Health Benefits ◽  
The Body ◽  
Future Research ◽  
Immune Systems ◽  
Advantages And Disadvantages ◽  
Immune System Modulation ◽  
Molecular Patterns

Intestinal microbiota interacts with other systems, especially the immune system, which is responsible for protecting the body by recognizing “stranger” (pathogen associated molecular patterns-PAMPs) and “danger” (damage-associated molecular patterns-DAMPs) molecular motifs. In this manner, it plays an important role in the pathogenesis of various diseases and health. Despite the use of probiotics that modulate the intestinal microbiota in providing health benefits and in the treatment of diseases, there are some possible concerns about the possibility of developing adverse effects, especially in people with suppressed immune systems. Since probiotics provide health benefits with bioactive compounds, studies are carried out on the use of products containing non-living probiotic microorganisms (paraprobiotics) and/or their metabolites (postbiotics) instead of probiotic products. It is even reported that these microbial compounds have more immunomodulatory activities than living microorganisms via some possible mechanism and eliminates some disadvantages of probiotics. Considering the increasing use of functional foods in health and disease, further studies are needed with respect to the benefits and advantages of parabiotic and/or postbiotic use in the food and pharmaceutical industry as well as immune system modulation. Although probiotics have been extensive studied for a long time, it seems that postbiotics are promising tools for future research and applications according to the recent literature. This review aimed to evaluate the interaction of probiotics and postbiotics with the immune systems and also their advantages and disadvantages in the area of food-pharmaceutical industry and immune system modulation.

scholarly journals A Systematic Literature Review of Multi-Criteria Decision-Making Methods for Sustainable Selection of Insulation Materials in Buildings

2021 ◽  
Vol 13 (2) ◽  
pp. 737
Author(s):  
Indre Siksnelyte-Butkiene ◽  
Dalia Streimikiene ◽  
Tomas Balezentis ◽  
Virgilijus Skulskis
Keyword(s):  
Decision Making ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Energy Demand ◽  
Energy Performance ◽  
Future Research ◽  
Multi Criteria Decision Making ◽  
Insulation Materials ◽  
Advantages And Disadvantages ◽  
Selection Of

The European Commission has recently adopted the Renovation Wave Strategy, aiming at the improvement of the energy performance of buildings. The strategy aims to at least double renovation rates in the next ten years and make sure that renovations lead to higher energy and resource efficiency. The choice of appropriate thermal insulation materials is one of the simplest and, at the same time, the most popular strategies that effectively reduce the energy demand of buildings. Today, the spectrum of insulation materials is quite wide, and each material has its own specific characteristics. It is recognized that the selection of materials is one of the most challenging and difficult steps of a building project. This paper aims to give an in-depth view of existing multi-criteria decision-making (MCDM) applications for the selection of insulation materials and to provide major insights in order to simplify the process of methods and criteria selection for future research. A systematic literature review is performed based on the Search, Appraisal, Synthesis and Analysis (SALSA) framework and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. In order to determine which MCDM method is the most appropriate for different questions, the main advantages and disadvantages of different methods are provided.

scholarly journals Application of electronic trigger tools to identify targets for improving diagnostic safety

2018 ◽  
Vol 28 (2) ◽  
pp. 151-159 ◽  
Author(s):  
Daniel R Murphy ◽  
Ashley ND Meyer ◽  
Dean F Sittig ◽  
Derek W Meeks ◽  
Eric J Thomas ◽  
...  
Keyword(s):  
Adverse Event ◽  
Patient Safety ◽  
High Risk ◽  
Health Systems ◽  
Language Processing ◽  
Diagnostic Errors ◽  
Diagnostic Process ◽  
Future Research ◽  
Implementation Challenges ◽  
Preventable Harm

Progress in reducing diagnostic errors remains slow partly due to poorly defined methods to identify errors, high-risk situations, and adverse events. Electronic trigger (e-trigger) tools, which mine vast amounts of patient data to identify signals indicative of a likely error or adverse event, offer a promising method to efficiently identify errors. The increasing amounts of longitudinal electronic data and maturing data warehousing techniques and infrastructure offer an unprecedented opportunity to implement new types of e-trigger tools that use algorithms to identify risks and events related to the diagnostic process. We present a knowledge discovery framework, the Safer Dx Trigger Tools Framework, that enables health systems to develop and implement e-trigger tools to identify and measure diagnostic errors using comprehensive electronic health record (EHR) data. Safer Dx e-trigger tools detect potential diagnostic events, allowing health systems to monitor event rates, study contributory factors and identify targets for improving diagnostic safety. In addition to promoting organisational learning, some e-triggers can monitor data prospectively and help identify patients at high-risk for a future adverse event, enabling clinicians, patients or safety personnel to take preventive actions proactively. Successful application of electronic algorithms requires health systems to invest in clinical informaticists, information technology professionals, patient safety professionals and clinicians, all of who work closely together to overcome development and implementation challenges. We outline key future research, including advances in natural language processing and machine learning, needed to improve effectiveness of e-triggers. Integrating diagnostic safety e-triggers in institutional patient safety strategies can accelerate progress in reducing preventable harm from diagnostic errors.

scholarly journals Going virtual: youth attitudes toward and experiences of virtual mental health and substance use services during the COVID-19 pandemic

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lisa D. Hawke ◽  
Natasha Y. Sheikhan ◽  
Karen MacCon ◽  
Joanna Henderson
Keyword(s):  
Mental Health ◽  
Substance Use ◽  
Youth Mental Health ◽  
Research Process ◽  
Clinical Samples ◽  
Future Research ◽  
Advantages And Disadvantages ◽  
Substance Use Services ◽  
Youth Attitudes ◽  
Virtual Services

Abstract Background During the COVID-19 pandemic, youth mental health and substance use services rapidly moved to virtual modalities to meet social distancing requirements. It is important to understand youth attitudes toward and experience of virtual services. Objective This study examined the attitudes toward and experiences of virtual mental health and substance use services among youth drawn from clinical and non-clinical samples. Method Four hundred nine youth completed a survey including questions about their attitudes toward and experience of virtual services. The survey included quantitative and open-ended questions on virtual care, as well as a mental health and substance use screener. Results The majority of youth with mental health or substance use challenges would be willing to consider individual virtual services, but fewer would consider group virtual services. However, many have not received virtual services. Youth are interested in accessing a wide variety of virtual services and other supportive wellness services. Advantages and disadvantages of virtual services are discussed, including accessibility benefits and technological barriers. Discussion As youth mental health and substance use services have rapidly gone virtual during the COVID-19 pandemic, it is essential that we hear the perspectives of youth to promote service utilization among those in need. Diverse, accessible, technologically stable virtual services are required to meet the needs of different youth, possibly with in-person options for some youth. Future research, engaging youth in the research process, is needed to evaluate the efficacy of virtual services to plan for the sustainability of some virtual service gains beyond the pandemic period.

scholarly journals A Review of Remote Sensing Image Dehazing

Sensors ◽  
2021 ◽  
Vol 21 (11) ◽  
pp. 3926
Author(s):  
Juping Liu ◽  
Shiju Wang ◽  
Xin Wang ◽  
Mingye Ju ◽  
Dengyin Zhang
Keyword(s):  
Remote Sensing ◽  
Data Driven ◽  
Future Research ◽  
Research Focus ◽  
Image Dehazing ◽  
Surface Information ◽  
Haze Removal ◽  
Advantages And Disadvantages ◽  
Extra Information ◽  
Removal Technique

Remote sensing (RS) is one of the data collection technologies that help explore more earth surface information. However, RS data captured by satellite are susceptible to particles suspended during the imaging process, especially for data with visible light band. To make up for such deficiency, numerous dehazing work and efforts have been made recently, whose strategy is to directly restore single hazy data without the need for using any extra information. In this paper, we first classify the current available algorithm into three categories, i.e., image enhancement, physical dehazing, and data-driven. The advantages and disadvantages of each type of algorithm are then summarized in detail. Finally, the evaluation indicators used to rank the recovery performance and the application scenario of the RS data haze removal technique are discussed, respectively. In addition, some common deficiencies of current available methods and future research focus are elaborated.

Latest Research and Developing Tendency of Hyperbranched Polymers Fabrication

2021 ◽  
Vol 896 ◽  
pp. 45-50
Author(s):  
Lian Yi Huo ◽  
Xue Tao Shi ◽  
Si Ming Chen ◽  
Meng Yao Zhang
Keyword(s):  
Reaction Mechanism ◽  
Ring Opening ◽  
Hyperbranched Polymers ◽  
Ring Opening Polymerization ◽  
Synthesis Process ◽  
Future Research ◽  
Advantages And Disadvantages ◽  
Environmental Friendly ◽  
High Efficient ◽  
The Future

Hyperbranched polymers (HBPs) have been applied in various fields because of its outstanding biodegradability and biocompatibility. At present, there are a variety of methods that are used to fabricate HBPs, such as polycondensation, reactive polymerization and ring-opening polymerization according to reaction mechanism. These methods are all environmental-friendly and high-efficient to generate HBPs, and are valuable for industrialization. In this work, we conclude some common methods of HBPs fabrication and make the comparison between them to analyze their advantages and disadvantages, which contribute in how to improve the synthesis process in the future research.

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