scholarly journals Spatial Distribution of Parkinson’s Disease Prevalence in Québec by Hydrographic Region

Author(s):  
Stephanie Rebecca Susser ◽  
Fabien Gagnon

AbstractThe association between environmental exposures and Parkinson’s disease continues to garner interest. In the late 1980s, Barbeau et al. reported in the Canadian Journal of Neurological Sciences a heterogeneous distribution of Parkinson’s disease cases across the province of Québec by hydrographic region. Here we report the findings of a validation study based on data obtained from the Québec medication insurance program–information which was unavailable to the previous group. Similar to Barbeau et al., our analysis showed a heterogeneous distribution of cases across the province with higher prevalence in the same region of interest, in addition to other areas.

2004 ◽  
Vol 19 (10) ◽  
pp. 1226-1232 ◽  
Author(s):  
Pablo Martínez-Martín ◽  
Carlos Salvador ◽  
Luis Menéndez-Guisasola ◽  
Sonia González ◽  
Aurelio Tobías ◽  
...  

2021 ◽  
Author(s):  
Qingguo Ren ◽  
Yihua Wang ◽  
Xiaomin Nan ◽  
Jianyuan Zhang ◽  
Xiangshui Meng ◽  
...  

Abstract Background We have established radiological protocol and made morphological measurement of the lentiform nucleus (LN) and the signal intensity which we used to discriminate parkinsonism predominant multiple system atrophy (MSA-P) from Parkinson’s disease (PD). But we don’t know whether it works especially in early stage of MSA-P. This case-control study aimed to investigate whether the new measurement of the morphological and intensity changes in susceptibility weighted imaging (SWI) of the LN could discriminate MSA-P from PD in their early stage and controls. Methods We retrospectively enrolled patients with MSA-P, PD, and sex- and age-matched controls between January 2015 and July 2020 at the Movement Disorder Center who underwent brain MR scanning with SWI sequence. Two specialists at the center reviewed the medical records and made the final diagnosis, and two experienced neuroradiologists performed MRI image analysis based on a defined radiological protocol to conduct the region of interest (ROI) based morphological measurements of the LN and the signal intensity. Results A total of 17 patients with MSA-P, 17 patients with PD within 2 years of the disease duration and 17 controls were enrolled in this study. We found that patients with MSA-P had significant decreased size in the short line (SL, cSL), and the ratio of the SL and the long line (SLLr, cSLLr) compared with the patients with PD and with the controls (P < 0.05). Combining these four indexes, this finding had a sensitivity of 58.8% and a specificity of 100% to distinguish MSA-P from PD. Conclusions As compared to PD and control subjects, the MSA-P patients are characterized by narrowing morphology of the posterior region of LN. The quantitative morphological change is a possible potential marker to differentiate MSA-P from PD in the early stage.


2012 ◽  
Vol 260 (5) ◽  
pp. 1332-1338 ◽  
Author(s):  
Maria G. Cersosimo ◽  
Gabriela B. Raina ◽  
Cristina Pecci ◽  
Alejandro Pellene ◽  
Cristian R. Calandra ◽  
...  

2008 ◽  
Vol 24 (3) ◽  
pp. 401-406 ◽  
Author(s):  
Edward J. Newman ◽  
Katherine A. Grosset ◽  
Donald G. Grosset

2020 ◽  
Vol 20 (5) ◽  
pp. 443-447
Author(s):  
Kyum‐Yil Kwon ◽  
Suyeon Park ◽  
Mina Lee ◽  
Hyunjin Ju ◽  
Kayeong Im ◽  
...  

2019 ◽  
Vol 26 (10) ◽  
pp. 1281-1288 ◽  
Author(s):  
P. Martinez‐Martin ◽  
F. G. Radicati ◽  
C. Rodriguez Blazquez ◽  
J. Wetmore ◽  
N. Kovacs ◽  
...  

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