scholarly journals PC3 - 191 Assessment of Preoperative Functional MRI Measurement of Language Lateralisation in Brain Tumour Patients

2016 ◽  
Vol 43 (S4) ◽  
pp. S20-S20
Author(s):  
E. Kosteniuk ◽  
J.C. Lau ◽  
J.F. Megyesi
Keyword(s):  
Brain Tumour ◽  
Preoperative Assessment ◽  
Sentence Completion ◽  
Hemispheric Dominance ◽  
Low Grade ◽  
Broca’S Area ◽  
Broca's Area ◽  
Lesion Type ◽  
Wernicke’S Area ◽  
Verb Generation

This study aims to evaluate reliability of clinical functional magnetic resonance imaging (fMRI) in identifying language lateralisation index (LI), verified with Edinburgh handedness inventory (EHI), in brain tumour patients. Methods In this retrospective study, 31 of a single surgeon’s brain tumour patients over a 12 year period have been selected. Lesion type varied, 12 (39 percent) were high grade gliomas, 10 (32 percent) low grade gliomas, 3 (10 percent) meningiomas, and 6 (19 percent) other types. Patients underwent language fMRI paradigms for preoperative assessment, and a neuroimaging analyst was able to identify an LI value for at least one Brodmann area (BA). For each paradigm, a neuroimaging analyst attempted to calculate LI for Wernicke’s area (BA 22) and Broca’s area (BA 44 and 45). Results Of 113 total LI values, 66 (58 percent) were concordant to EHI-predicted hemispheric dominance. Reliability of language LI appears dependent upon the type of language task performed. Verb generation correctly identified Broca’s area in 18 patients (64 percent) and Wernicke’s area in 11 patients (61 percent), sentence completion correctly identified Broca’s area in 18 patients (72 percent) and Wernicke’s area in 9 patients (60 percent), and naming correctly identified Broca’s area in 7 patients (47 percent) and Wernicke’s area in 3 patients (27 percent). Conclusions Results show limited correlation between language LI determined by fMRI and EHI. The main limitation of this study is that language LI is being compared to EHI, rather than gold standard measure of hemispheric dominance (e.g. Wada).

scholarly journals fMRI Evidence for Cortical Modification during Learning of Mandarin Lexical Tone

2003 ◽  
Vol 15 (7) ◽  
pp. 1019-1027 ◽  
Author(s):  
Yue Wang ◽  
Joan A. Sereno ◽  
Allard Jongman ◽  
Joy Hirsch
Keyword(s):  
Second Language ◽  
Inferior Frontal Gyrus ◽  
Superior Temporal Gyrus ◽  
Broca’S Area ◽  
Lexical Tone ◽  
Broca's Area ◽  
Language Functions ◽  
Before And After ◽  
Cortical Regions ◽  
Wernicke’S Area

Functional magnetic resonance imaging was employed before and after six native English speakers completed lexical tone training as part of a program to learn Mandarin as a second language. Language-related areas including Broca's area, Wernicke's area, auditory cortex, and supplementary motor regions were active in all subjects before and after training and did not vary in average location. Across all subjects, improvements in performance were associated with an increase in the spatial extent of activation in left superior temporal gyrus (Brodmann's area 22, putative Wernicke's area), the emergence of activity in adjacent Brodmann's area 42, and the emergence of activity in right inferior frontal gyrus (Brodmann's area 44), a homologue of putative Broca's area. These findings demonstrate a form of enrichment plasticity in which the early cortical effects of learning a tone-based second language involve both expansion of preexisting language-related areas and recruitment of additional cortical regions specialized for functions similar to the new language functions.

scholarly journals Wernicke’s area and broca’s area in functional connectivity of language

2019 ◽  
Author(s):  
Fernando Villanueva Junes ◽  
Eduardo Barragan ◽  
Daniel Alvarez ◽  
Pilar Dies ◽  
Silvia Hidalgo Tobon
Keyword(s):  
Functional Connectivity ◽  
Broca’S Area ◽  
Broca's Area ◽  
Wernicke’S Area

Spatiotemporal Brain Activity During Hiragana Word Recognition Task

2011 ◽  
Vol 15 (3) ◽  
pp. 357-361 ◽  
Author(s):  
Hisashi Toyoshima ◽  
◽  
Takahiro Yamanoi ◽  
Toshimasa Yamazaki ◽  
Shin-ichi Ohnishi ◽  
...  
Keyword(s):  
Brain Activity ◽  
Recognition Task ◽  
Event Related Potentials ◽  
Dipole Source ◽  
Broca’S Area ◽  
Broca's Area ◽  
Current Dipole ◽  
Related Potentials ◽  
Wernicke’S Area ◽  
The Right

The 19-channel Event-Related Potentials (ERPs) we recorded during recognition of hiragana (one type of Japanese phonetic characters) were simultaneously and independently presented as a word and a nonword to opposite eyes using a field-sequential stereoscopic 3D display with a liquid-crystal shutter, a word and a non-word were simultaneously and independently presented to the left (right) and the right (left) eyes, respectively. Each word consists of 3 hiragana characters. Three subjects were instructed to press a button when they understood the meaning of the visual stimuli after 3,000 ms poststimulus. Equivalent Current Dipole source Localization (ECDL) with 3 unconstrained ECDs was applied to the ERPs. In the case of right-handed subjects, the ECDs were localized to the Wernicke’s area at around 600 ms. In the case of left-handed subject, the ECD was localized to the Wernicke’s homologue. After that ECDs were then localized to the prefrontal area, the superior frontal gyrus, and the middle frontal gyrus. At around 800 ms, the ECDs were localized to the Broca’s area, then after that ECDs were relocalized to the the Wernicke’s area and to the Broca’s area.

scholarly journals Functional Translocation of Broca's Area in a Low-Grade Left Frontal Glioma: Graph Theory Reveals the Novel, Adaptive Network Connectivity

2019 ◽  
Vol 10 ◽  
Author(s):  
Qiongge Li ◽  
Jian W. Dong ◽  
Gino Del Ferraro ◽  
Nicole Petrovich Brennan ◽  
Kyung K. Peck ◽  
...  
Keyword(s):  
Graph Theory ◽  
Network Connectivity ◽  
Low Grade ◽  
The Novel ◽  
Broca’S Area ◽  
Broca's Area ◽  
Adaptive Network

scholarly journals Localization of Broca's area using verb generation tasks in the MEG: Validation against fMRI

2011 ◽  
Vol 490 (3) ◽  
pp. 215-219 ◽  
Author(s):  
Elizabeth W. Pang ◽  
Frank Wang ◽  
Marion Malone ◽  
Darren S. Kadis ◽  
Elizabeth J. Donner
Keyword(s):  
Broca’S Area ◽  
Broca's Area ◽  
Verb Generation

scholarly journals fMRI activation in the middle frontal gyrus as an indicator of hemispheric dominance for language in brain tumor patients: a comparison with Broca’s area

2016 ◽  
Vol 58 (5) ◽  
pp. 513-520 ◽  
Author(s):  
Jian W. Dong ◽  
Nicole M. Petrovich Brennan ◽  
Giana Izzo ◽  
Kyung K. Peck ◽  
Andrei I. Holodny
Keyword(s):  
Brain Tumor ◽  
Middle Frontal Gyrus ◽  
Hemispheric Dominance ◽  
Broca’S Area ◽  
Broca's Area ◽  
Tumor Patients

RESECTION OF WORLD HEALTH ORGANIZATION GRADE II GLIOMAS INVOLVING BROCA'S AREA

Neurosurgery ◽  
2007 ◽  
Vol 61 (4) ◽  
pp. 741-753 ◽  
Author(s):  
Mohammed Benzagmout ◽  
Peggy Gatignol ◽  
Hugues Duffau
Keyword(s):  
Brain Plasticity ◽  
Premotor Cortex ◽  
Intractable Epilepsy ◽  
World Health ◽  
Cortical Mapping ◽  
Magnetic Resonance Imaging Scan ◽  
Low Grade ◽  
Broca’S Area ◽  
Broca's Area ◽  
Health Organization

Abstract OBJECTIVE Advances in functional mapping have enabled us to extend the indications of surgery for low-grade gliomas (LGGs) within eloquent regions. However, to our knowledge, no study has been specifically dedicated to the resection of LGGs within Broca's area. We report the first surgical series of LGGs involving this area by focusing on methodological and functional considerations. METHODS Seven patients harboring an LGG in Broca's area (revealed by partial seizures) had a language functional magnetic resonance imaging scan and then underwent operation while awake using intrasurgical electrical mapping. RESULTS The neurological examination was normal in all patients despite mild language disturbances shown using the Boston Diagnosis Aphasia Examination. Both pre- and intraoperative cortical mapping found language reorganization with recruitment of the ventral and dorsal premotor cortices, orbitofrontal cortex, and insula, whereas no or few language sites were detected within Broca's area. Subcortically, electrostimulation allowed the identification and preservation of four structures still functional, including the arcuate fasciculus, fronto-occipital fasciculus, fibers from the ventral premotor cortex, and head of the caudate. Postoperatively, after transient language worsening, all patients recovered and returned to a normal socioprofessional life. The resection was total in three cases, subtotal in three, and partial in one patient (operated twice). CONCLUSION Our results indicate that, in patients with no aphasia despite LGGs within Broca's area, thanks to brain plasticity, the tumor can be removed while involving this “unresectable” structure without inducing sequelae and even improving the quality of life when intractable epilepsy is relieved on the condition that subcortical language connectivity is preserved.

scholarly journals Prior Neurosurgery Decreases fMRI Estimates of Language Laterality in Patients with Gliomas within Anterior Language Sites

2021 ◽  
Vol 10 (7) ◽  
pp. 1491
Author(s):  
Monika M. Połczyńska ◽  
Bryan Ding ◽  
Bianca H. Dang ◽  
Lucia Cavanagh
Keyword(s):  
Right Hemisphere ◽  
Region Of Interest ◽  
Brain Surgery ◽  
Broca’S Area ◽  
Broca's Area ◽  
Language Dominance ◽  
Two Samples ◽  
Prior Surgery ◽  
Wernicke’S Area ◽  
The Impact

The impact of previous surgery on the assessment of language dominance with preoperative fMRI remains inconclusive in patients with recurrent brain tumors. Samples in this retrospective study included 17 patients with prior brain surgery and 21 patients without prior surgery (38 patients total; mean age 43.2, SD = 11.9; 18 females; seven left-handed). All the patients were left language dominant, as determined clinically. The two samples were matched on 10 known confounds, including, for example, tumor laterality and location (all tumors affected Brodmann areas 44/45/47). We calculated fMRI language dominance with laterality indices using a whole-brain and region of interest approach (ROI; Broca’s and Wernicke’s area). Patients with prior surgery had decreased fMRI language dominance (p = 0.03) with more activity in the right hemisphere (p = 0.03) than patients without surgery. Patients with prior brain surgery did not display less language activity in the left hemisphere than patients without surgery. These results were replicated using an ROI approach in the affected Broca’s area. Further, we observed no differences between our samples in the unaffected Wernicke’s area. In sum, prior brain surgery affecting Broca’s area could be a confounding factor that needs to be considered when evaluating fMRI language dominance.

scholarly journals Awake resection of a left operculo-insular low-grade glioma guided by cortico-subcortical mapping

2018 ◽  
Vol 45 (VideoSuppl2) ◽  
pp. V1 ◽  
Author(s):  
Thiébaud Picart ◽  
Hugues Duffau
Keyword(s):  
Anterior Part ◽  
Premotor Cortex ◽  
Naming Task ◽  
Medical Doctor ◽  
Low Grade Glioma ◽  
Cortical Mapping ◽  
Low Grade ◽  
Broca’S Area ◽  
Broca's Area ◽  
Awake Resection

A 30-year-old right-handed female medical doctor experienced generalized seizures. MRI showed a left operculo-insular low-grade glioma. Awake resection was proposed. During the cortical mapping, counting and naming task combined with right upper limb movement enabled the identification of the ventral premotor cortex and negative motors areas. The so-called Broca’s area was not eloquent. Subpial dissection was performed by avoiding coagulation until the inferior fronto-occipital fasciculus and the junction between the output projection fibers and the anterior part of the superior longitudinal fasciculus III were reached. The patient resumed a normal familial and socio-professional life despite the resection of Broca’s area.The video can be found here: https://youtu.be/OALk0tvctQw.

Sign in / Sign up

Export Citation Format

Share Document