Right brain to right brain therapy: how tactile, expressive arts therapy emulates attachment

2020 ◽  
Vol 45 (2) ◽  
pp. 91-96
Author(s):  
Melissa Urquhart ◽  
Fiona Gardner ◽  
Margarita Frederico ◽  
Rachael Sanders
Keyword(s):  
Play Therapy ◽  
Expressive Arts ◽  
Expressive Arts Therapy ◽  
Therapeutic Benefits ◽  
Right Brain ◽  
Therapeutic Outcomes ◽  
Therapy Technique ◽  
Relational Trauma ◽  
The Impact

AbstractThe impact of a manipulative art therapy technique combined with an attuned therapeutic relationship which aims to replicate the experience of nurturing touch in infancy is explored in this paper. The current literature will be reviewed in relation to the interface between attachment-related trauma and the use of expressive art and play therapy in the context of relevant clinical experience. Specific experiences of clinical practice with children and associated therapeutic outcomes are used to illustrate the potential of this combination. In addition, we argue for further investigation of therapeutic benefits inherent in manipulative art and play in replication of the regulating role of touch with children who have experienced early relational trauma.

scholarly journals Nano-Biomimetic Drug Delivery Vehicles: Potential Approaches for COVID-19 Treatment

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5952
Author(s):  
Bwalya A. Witika ◽  
Pedzisai A. Makoni ◽  
Larry L. Mweetwa ◽  
Pascal V. Ntemi ◽  
Melissa T. R. Chikukwa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Inflammatory Diseases ◽  
Cell Types ◽  
Charge Composition ◽  
Drug Delivery Vehicles ◽  
Therapeutic Outcomes ◽  
Delivery Vehicles ◽  
The Impact

The current COVID-19 pandemic has tested the resolve of the global community with more than 35 million infections worldwide and numbers increasing with no cure or vaccine available to date. Nanomedicines have an advantage of providing enhanced permeability and retention and have been extensively studied as targeted drug delivery strategies for the treatment of different disease. The role of monocytes, erythrocytes, thrombocytes, and macrophages in diseases, including infectious and inflammatory diseases, cancer, and atherosclerosis, are better understood and have resulted in improved strategies for targeting and in some instances mimicking these cell types to improve therapeutic outcomes. Consequently, these primary cell types can be exploited for the purposes of serving as a “Trojan horse” for targeted delivery to identified organs and sites of inflammation. State of the art and potential utilization of nanocarriers such as nanospheres/nanocapsules, nanocrystals, liposomes, solid lipid nanoparticles/nano-structured lipid carriers, dendrimers, and nanosponges for biomimicry and/or targeted delivery of bioactives to cells are reported herein and their potential use in the treatment of COVID-19 infections discussed. Physicochemical properties, viz., hydrophilicity, particle shape, surface charge, composition, concentration, the use of different target-specific ligands on the surface of carriers, and the impact on carrier efficacy and specificity are also discussed.

scholarly journals A Process Description of Playing to Live! A Community Psychosocial Arts Program During Ebola

2017 ◽  
Vol 11 (1) ◽  
Author(s):  
C. Alexis Decosimo ◽  
Jessi E Hanson ◽  
Catherine Reilly Boland ◽  
Deborah Slawson ◽  
Mary Ann Littleton ◽  
...  
Keyword(s):  
Large Scale ◽  
Ebola Virus ◽  
Virus Disease ◽  
Current Theory ◽  
Expressive Arts ◽  
Ebola Virus Disease ◽  
Expressive Arts Therapy ◽  
Activity Data ◽  
Community Program ◽  
The Impact

From 2014 to 2015, Liberia experienced the largest Ebola epidemic in world history. The impact of this disease was not only physical; it created fear, loss, and trauma throughout the country. This article will describe the process of three phases of a community-based psychosocial expressive arts program, which used theory from the fields of expressive arts therapy to build mental health capacity during and after the epidemic. This article will highlight the background of Ebola virus disease and the Ebola virus disease epidemic, provide an overview of current theory and research for expressive arts therapy and the impact of trauma, describe the process of how the program developed and was implemented, the process of partnering with the community, program components, the two pilot programs, and the large-scale community program. We performed a mixed-methods analysis of the large-scale program’s activity data to evaluate the impact. The results highlight a positive response from the participating children and facilitators. The authors discuss the findings from the results, best practices, and limitations. Additionally, the authors discuss implications and considerations for future programming.

The possible role of Saponin in Type-II Diabetes- A review

2020 ◽  
Vol 16 ◽  
Author(s):  
Neeraj Choudhary ◽  
Gopal Lal Khatik ◽  
Ashish Suttee
Keyword(s):  
Secondary Metabolites ◽  
Type Ii Diabetes ◽  
Structural Diversity ◽  
Complete Information ◽  
Current Data ◽  
Type Ii ◽  
Glucose Levels ◽  
Therapeutic Benefits ◽  
The Impact

Background: The possible role of secondary metabolites in the management of diabetes is a great concern and constant discussion. This characteristic seems relevant and should be the subject of thorough discussion with respect to saponin. Objective: Current data mainly focus on the impact of saponin in the treatment of type-II diabetes. The majority of studies emphasis on other secondary metabolites such as alkaloids and flavonoids but very few papers are there representing the possible role of saponin as these papers express the narrow perspective of saponin phytoconstituents but lacking in providing the complete information on various saponin plants. The aim of the study was to summarize all available data concerning the saponin containing plant in the management of type-II diabetes. Methods: All relevant papers on saponin were selected. This review summarizes the saponins isolation method, mechanism of action, clinical significance, medicinal plants and phytoconstituents responsible for producing a therapeutic effect in the management of diabetes. Results: The saponin is of high potential with structural diversity and inhibits diabetic complications along with reducing the hyperglycemia through different mechanisms thereby providing scope for improving the existing therapy and developing the novel medicinal agents for curing diabetes. Conclusion: Saponins having potential therapeutic benefits and are theorized as an alternative medication in decreasing serum blood glucose levels in the patient suffering from diabetes.

scholarly journals Minimising The Counter-Therapeutic Effects Of Coronial Investigations: In Search Of Balance

2016 ◽  
Vol 16 (3) ◽  
pp. 4 ◽  
Author(s):  
Ian Freckelton
Keyword(s):  
Therapeutic Potential ◽  
Empirical Studies ◽  
Family Members ◽  
Therapeutic Jurisprudence ◽  
Therapeutic Effects ◽  
Counselling Services ◽  
Therapeutic Outcomes ◽  
Fact Finding ◽  
The Impact

<p><em><span style="font-size: medium;">For more than a decade analyses of coronial processes inspired by both therapeutic jurisprudence and restorative justice have identified the potential for maximising the therapeutic and public health benefits of the investigative functions of coroners’ courts and minimising their counter-therapeutic potential. The focus of both scholarly literature and law reform proposals has been upon addressing deficits in respect of the role of families in coronial investigations and especially coroners’ inquests. This has been a constructive contribution and has improved sensitivity to the risk that family members will be disenfranchised and alienated at a highly vulnerable time after they have been bereaved. This article chronicles the development in awareness of such issues. However, the potential for adv­erse effects on parties other than family members has been inadequately recognised in the literature, save for empirical studies conducted in 2011 for the Coronial Council of Victoria and another study published in 2014 in New Zealand. This article seeks to redress that imbalance. It argues that it is appropriate also to have regard to such potential in endeavouring to provide an approach to the work of coroners that is influenced by the sensibilities of therapeutic jurisprudence and seeks to reduce, so far as possible, counter-therapeutic outcomes for all parties, at the same time prioritising accurate and robust fact-finding and formulation of constructive recommendations to avoid avoidable deaths. It calls for further empirical research on the impact of coroners’ investigations on all affected parties and argues in favour of extension of improved funding to enable approaches to be informed by therapeutic jurisprudence and in particular to enhance eligibility for the services of counselling services attached to coroners’ courts.</span></em></p>

Development of Hydrologic Concepts in the Northeastern United States

1983 ◽  
Vol 2 (2) ◽  
pp. 165-168
Author(s):  
Martina Johnson
Keyword(s):  
United States ◽  
Analytical Techniques ◽  
The United States ◽  
Northeastern United States ◽  
Mineral Springs ◽  
Erie Canal ◽  
Therapeutic Benefits ◽  
The Impact ◽  
The Relationship

Significant contributions to hydrogeology from the Northeastern United States have resulted from studies of natural phenomena, the occurrence of mineral springs, and two man-made events - the drilling in 1824 of the first fresh water well in the U.S., and the building of the Erie Canal. Development of chemical analytical techniques was prompted by interest in the therapeutic benefits of Saratoga and similar mineral springs, which were used as spas and sources of bottled water. The fundamental concept that the chemical character of ground water is controlled by lithology and by source and movement of water evolved from efforts to explain the origin and chemical differences of springs that were believed to have different medicinal benefits. The first drilled well, at the mouth of the Raritan River, led to the study of saltwater encroachment in the United States. The concept that explains the relationship between freshwater head and the position of the saltwater interface was developed to explain the ebbing and flowing of the well. Although the early hydrologic work was undertaken primarily by chemists and engineers, it was largely the challenge of understanding the position and movement of the saltwater interface that required the talents of geologists from whose studies evolved fundamental hydrogeologic concepts. Even now, evaluation of the role of the zone of dispersion in diagenesis, ore deposition, and geomorphic processes is at the forefront of hydrogeologic research. The building of the Erie Canal demonstrated the delicate ecologic balance of water systems and the need to anticipate the impact of man-made structures on this balance. Hydrologic engineering was advanced during its construction owing to the challenge of controlling the volume of water as well as its depth and velocity.

scholarly journals Autophagy: New Insights into Mechanisms of Action and Resistance of Treatment in Acute Promyelocytic leukemia

2019 ◽  
Vol 20 (14) ◽  
pp. 3559 ◽  
Author(s):  
Mohammad Amin Moosavi ◽  
Mojgan Djavaheri-Mergny
Keyword(s):  
Acute Promyelocytic Leukemia ◽  
Retinoic Acid Receptor ◽  
Mechanisms Of Action ◽  
Promyelocytic Leukemia ◽  
Development Of Resistance ◽  
Therapeutic Benefits ◽  
Differentiating Agent ◽  
Cancer Agent ◽  
The Impact

Autophagy is one of the main cellular catabolic pathways controlling a variety of physiological processes, including those involved in self-renewal, differentiation and death. While acute promyelocytic leukemia (APL) cells manifest low levels of expression of autophagy genes associated with reduced autophagy activity, the introduction of all-trans retinoid acid (ATRA)—a differentiating agent currently used in clinical settings—restores autophagy in these cells. ATRA-induced autophagy is involved in granulocytes differentiation through a mechanism that involves among others the degradation of the PML-RARα oncoprotein. Arsenic trioxide (ATO) is another anti-cancer agent that promotes autophagy-dependent clearance of promyelocytic leukemia retinoic acid receptor alpha gene (PML-RARα) in APL cells. Hence, enhancing autophagy may have therapeutic benefits in maturation-resistant APL cells. However, the role of autophagy in response to APL therapy is not so simple, because some autophagy proteins have been shown to play a pro-survival role upon ATRA and ATO treatment, and both agents can activate ETosis, a type of cell death mediated by the release of neutrophil extracellular traps (ETs). This review highlights recent findings on the impact of autophagy on the mechanisms of action of ATRA and ATO in APL cells. We also discuss the potential role of autophagy in the development of resistance to treatment, and of differentiation syndrome in APL.

scholarly journals Porphyromonas gingivalis, a Long-Range Pathogen: Systemic Impact and Therapeutic Implications

2020 ◽  
Vol 8 (6) ◽  
pp. 869 ◽  
Author(s):  
Hannah Mulhall ◽  
Olivier Huck ◽  
Salomon Amar
Keyword(s):  
Porphyromonas Gingivalis ◽  
Potential Mechanism ◽  
Periodontal Pathogens ◽  
Oral Flora ◽  
Therapeutic Implications ◽  
Gut Dysbiosis ◽  
Therapeutic Outcomes ◽  
Systemic Impact ◽  
The Impact

Periodontitis is an inflammatory disease associated with a dysbiosis of the oral flora characterized by a chronic sustained inflammation leading to destruction of tooth-supporting tissues. Over the last decade, an association between periodontitis and systemic disorders such as cardiovascular diseases, rheumatoid arthritis and obesity has been demonstrated. The role of periodontal pathogens, notably Porphyromonas gingivalis (P. gingivalis), in the onset or exacerbation of systemic diseases has been proposed. P. gingivalis expresses several virulence factors that promote its survival, spreading, and sustaining systemic inflammation. Recently, the impact of periodontitis on gut dysbiosis has also been suggested as a potential mechanism underlying the systemic influence of periodontitis. New therapeutic strategies for periodontitis and other dysbiotic conditions, including the use of beneficial microbes to restore healthy microbial flora, may pave the way to improved therapeutic outcomes and more thorough patient management.

scholarly journals NACC-1 regulates hepatocellular carcinoma cell malignancy and is targeted by miR-760

2020 ◽  
Vol 52 (3) ◽  
pp. 302-309
Author(s):  
Linan Yin ◽  
Tingting Sun ◽  
Ruibao Liu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Lines ◽  
Bioinformatic Analysis ◽  
Cellular Growth ◽  
Luciferase Assay ◽  
Migration And Invasion ◽  
Cellular Processes ◽  
Therapeutic Benefits ◽  
The Impact

Abstract Hepatocellular carcinoma (HCC) is the most prominent form of presentation in liver cancer. It is also the fourth most common cause of cancer-associated deaths globally. The role of nucleus accumbens associated protein-1 (NACC-1) has been evaluated in several cancers. This protein is a transcriptional regulator that regulates a number of significant cellular processes. In the current study, we aimed to understand the role of NACC-1 in HCC. Primarily, we measured the expression of NACC-1 using quantitative real time polymerase chain reaction and western blot analysis. We knocked down the expression of NACC-1 in HCC cell lines Huh7 and HepG2 by transferring a commercially synthesized small interfering RNA and explored the impact of NACC-1 knockdown on cellular growth, migration, invasion, and chemoresistance to doxorubicin. Through bioinformatic analysis, we identified NACC-1 as a potential target of miR-760. Using a dual reporter luciferase assay, we confirmed the predicted target and assessed miR-760-mediated regulation of NACC-1 and rescue of tumorigenic phenotypes. We observed increased expression of NACC-1 in HCC. Furthermore, knockdown of NACC-1 resulted in reduced cell proliferation and invasion and increased susceptibility to doxorubicin-mediated chemosensitivity. Overexpression of miR-760 in HCC cell lines rescued NACC-1-mediated migration and invasion. We revealed that miR-760 regulated NACC-1 expression in HCC. Our data indicated that both miR-760 and NACC-1 could be used as prognostic markers, and miR-760 may have therapeutic benefits for HCC and other cancers.

The Safe Space

2017 ◽  
pp. 81-99
Author(s):  
Cary McAdams Hamilton ◽  
Hannah E. Reas ◽  
Megan E. Mansfield
Keyword(s):  
Play Therapy ◽  
Limbic System ◽  
Clinical Vignette ◽  
Safe Space ◽  
Traumatized Children ◽  
System A ◽  
Therapeutic Benefits ◽  
Neural Integration ◽  
The Impact ◽  
The Brain

This chapter illustrates the neurobiological effects of trauma on children, as well as the therapeutic benefits of play therapy as a stand-alone treatment for this population. The goal of this work includes providing a framework for the neurobiological effects of trauma on children, as well as the various advantages of play therapy as an effective intervention. Play, specifically, meets children where they are in their development, while also attending to the neurobiological effects that trauma can have on the brain. The primary neurobiological structures implicated and targeted by client-centered play-based interventions are discussed, as well as the impact play therapy has on neural integration, memory assimilation, and the limbic system. A clinical vignette from the principal author's practice and experience working with traumatized children is included to elucidate the healing nature of play.

scholarly journals Interdisciplinary Innovations Utilizing Pet Robots to Meet Research, Education, and Care Needs

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 981-981
Author(s):  
Meredith Troutman-Jordan ◽  
Boyd Davis
Keyword(s):  
Research Experience ◽  
Structured Interviews ◽  
Care Needs ◽  
Field Exposure ◽  
Research Education ◽  
Therapeutic Benefits ◽  
Therapeutic Outcomes ◽  
Education And Care ◽  
Interviewing Techniques ◽  
The Impact

Abstract Studies of the impact of robotic companion pets are proliferating, authored by several disciplines, each with different concerns. Roboticists focus on technology design and artificial emotional intelligence as opposed to general preferences for soft, furry, interactive animals. Others worry that as people interact with potentially deceptive technology, they may think the pet is alive. While aware of these serious concerns, gerontologists have focused on how lonely older persons without cognitive impairment respond to social ‘helper’ robots. More recent studies emphasize the possible impact of animatronic pets on persons with dementia (PWD). Therapeutic benefits of these pets are just being established. Our current pilot study is timely in that it now involves semi-structured interviews with formal/ informal caregivers of PWD who have been given a robot pet. We are eliciting perceptions, opinions, and observations of the PWD’s response to robotic pets. We recruited 8 gerontology students as much-needed assistants for a research-driven topics course to afford them field exposure to PWD, caregivers, and direct research experience. Because students seldom have experience either with robotic pets or PWD, they read selected articles and received training/practice in semi-structured interviewing techniques. Students next conducted interviews with caregivers of PWD who have interacted with the pets. All interviews are audio-recorded, transcribed and deposited in the Carolinas Conversations Collection. Content and thematic analysis of transcriptions, student activity logs and bi-weekly reflective discussions will inform next steps in intervention research, testing therapeutic outcomes such as agitation reduction by pet robots for PWD.

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