The effect of atypical antipsychotic medications in individuals with anorexia nervosa: A systematic review and meta-analysis

2012 ◽  
Vol 46 (4) ◽  
pp. 332-339 ◽  
Author(s):  
Jocelyn Lebow ◽  
Leslie A. Sim ◽  
Patricia J. Erwin ◽  
M. Hassan Murad
Keyword(s):  
Systematic Review ◽  
Anorexia Nervosa ◽  
Atypical Antipsychotic ◽  
Meta Analysis ◽  
Antipsychotic Medications ◽  
Atypical Antipsychotic Medications

Risk of Death with Atypical Antipsychotic Medications for Dementia

2018 ◽  
Author(s):  
Adam P. Mecca ◽  
Rajesh R. Tampi
Keyword(s):  
Side Effects ◽  
Atypical Antipsychotic ◽  
Odds Ratio ◽  
Clinical Case ◽  
Atypical Antipsychotics ◽  
Meta Analysis ◽  
Antipsychotic Medications ◽  
Risk Of Death ◽  
Increased Risk ◽  
Atypical Antipsychotic Medications

This chapter provides a summary of a landmark meta-analysis that investigated the risks of atypical antipsychotic use to treat psychosis, aggression, or agitation in patients with dementia. The chapter briefly reviews the study design, as well as implications and limitations. A relevant clinical case concludes the chapter. In summary, atypical antipsychotic use for 6 to 26 weeks was associated with increased risk of death (Odds Ratio of 1.54 for antipsychotic vs placebo). There were no differences in risk between individual medications, disease severity, indication for antipsychotic, or treatment setting. In patients with psychosis, agitation, or aggression due to dementia, the efficacy of atypical antipsychotics is questionable and their use comes with considerable risks of side effects and adverse events.

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