Comorbidity and risk indicators for alcohol use disorders among persons with anxiety and/or depressive disorders: Findings from the Netherlands Study of Depression and Anxiety (NESDA)

2012 ◽  
Vol 2012 ◽  
pp. 330-331
Author(s):  
J.C. Ballenger
Keyword(s):  
Alcohol Use ◽  
The Netherlands ◽  
Depressive Disorders ◽  
Alcohol Use Disorders ◽  
Risk Indicators ◽  
Depression And Anxiety

scholarly journals Comorbidity and risk indicators for alcohol use disorders among persons with anxiety and/or depressive disorders

2011 ◽  
Vol 131 (1-3) ◽  
pp. 233-242 ◽  
Author(s):  
Lynn Boschloo ◽  
Nicole Vogelzangs ◽  
Johannes H. Smit ◽  
Wim van den Brink ◽  
Dick J. Veltman ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Depressive Disorders ◽  
Alcohol Use Disorders ◽  
Risk Indicators

scholarly journals The influence of the comorbidity between depression and alcohol use disorder on suicidal behaviors in the São Paulo Epidemiologic Catchment Area Study, Brazil

2010 ◽  
Vol 32 (4) ◽  
pp. 396-408 ◽  
Author(s):  
Bruno Mendonça Coêlho ◽  
Laura Helena Andrade ◽  
Francisco Bevilacqua Guarniero ◽  
Yuan-Pang Wang
Keyword(s):  
Substance Use ◽  
Alcohol Use ◽  
Substance Use Disorders ◽  
Depressive Episode ◽  
Depressive Disorders ◽  
Major Depressive Episode ◽  
Alcohol Use Disorders ◽  
Major Depressive ◽  
And Behaviors ◽  
And Gender

OBJECTIVE: To investigate in a community sample the association of suicide-related cognitions and behaviors ("thoughts of death", "desire for death", "suicidal thoughts", and "suicidal attempts") with the comorbidity of depressive disorders (major depressive episode or dysthymia) and alcohol or substance use disorders. METHOD: The sample was 1464 subjects interviewed in their homes using the Composite International Diagnostic Interview to generate DSM-III-R diagnosis. Descriptive statistics depicted the prevalence of suicide-related cognitions and behaviors by socio-demographic variables and diagnoses considered (major depressive episode, dysthymia, alcohol or substance use disorders). We performed a multivariate logistic regression analysis to estimate the effect of comorbid major depressive episode/dysthymia and alcohol or substance use disorders on each of the suicide-related cognitions and behaviors. RESULTS: The presence of major depressive episode and dysthymia was significantly associated with suicide-related cognitions and behaviors. In the regression models, suicide-related cognitions and behaviors were predicted by major depressive episode (OR = range 2.3-9.2) and dysthymia (OR = range 5.1-32.6), even in the presence of alcohol use disorders (OR = range 2.3-4.0) or alcohol or substance use disorders (OR = range 2.7-2.8). The interaction effect was observed between major depressive episode and alcohol use disorders, as well as between dysthymia and gender. Substance use disorders were excluded from most of the models. CONCLUSION: Presence of major depressive episode and dysthymia influences suicide-related cognitions and behaviors, independently of the presence of alcohol or substance use disorders. However, alcohol use disorders and gender interact with depressive disorders, displaying a differential effect on suicide-related cognitions and behaviors.

scholarly journals The Emerging Role of LHb CaMKII in the Comorbidity of Depressive and Alcohol Use Disorders

2020 ◽  
Vol 21 (21) ◽  
pp. 8123
Author(s):  
Chaya Shor ◽  
Wanhong Zuo ◽  
Jean D. Eloy ◽  
Jiang-Hong Ye
Keyword(s):  
Alcohol Use ◽  
Depressive Disorders ◽  
Alcohol Use Disorders ◽  
Lateral Habenula ◽  
Calcium Calmodulin Dependent ◽  
Targeted Treatments ◽  
Serotonin Neurons ◽  
Significant Public Health ◽  
Core Components ◽  
Dependent Protein

Depressive disorders and alcohol use disorders are widespread among the general population and are significant public health and economic burdens. Alcohol use disorders often co-occur with other psychiatric conditions and this dual diagnosis is called comorbidity. Depressive disorders invariably contribute to the development and worsening of alcohol use disorders, and vice versa. The mechanisms underlying these disorders and their comorbidities remain unclear. Recently, interest in the lateral habenula, a small epithalamic brain structure, has increased because it becomes hyperactive in depression and alcohol use disorders, and can inhibit dopamine and serotonin neurons in the midbrain reward center, the hypofunction of which is believed to be a critical contributor to the etiology of depressive disorders and alcohol use disorders as well as their comorbidities. Additionally, calcium/calmodulin-dependent protein kinase II (CaMKII) in the lateral habenula has emerged as a critical player in the etiology of these comorbidities. This review analyzes the interplay of CaMKII signaling in the lateral habenula associated with depressive disorders and alcohol use disorders, in addition to the often-comorbid nature of these disorders. Although most of the CaMKII signaling pathway’s core components have been discovered, much remains to be learned about the biochemical events that propagate and link between depression and alcohol abuse. As the field rapidly advances, it is expected that further understanding of the pathology involved will allow for targeted treatments.

scholarly journals Perceived Stress, Depression and Alcohol Use Disorders in College Students During the COVID-19 Pandemic: A Socio-Economic Dimension

2020 ◽  
Author(s):  
Beata Gavurova ◽  
Viera Ivankova ◽  
Martin Rigelsky
Keyword(s):  
College Students ◽  
Alcohol Use ◽  
Perceived Stress ◽  
Depressive Disorders ◽  
Alcohol Use Disorders ◽  
Diagnostic Tools ◽  
Significant Positive Effect ◽  
Excessive Alcohol Consumption ◽  
Economic Dimension ◽  
Positive Effect

The objective of the study was to examine the effects of perceived stress on depression and subsequently to examine the effects of depression on alcohol use disorders. The data were obtained by an electronic questionnaire survey during the coronavirus disease 2019 (COVID-19) pandemic (n=1523 Slovak college students). Descriptive, regression and correlation analysis were used in the analytical processing, while the analyses included students' scores in three diagnostic tools (Perceived Stress Scale (PSS), Patient Health Questionnaire for depression (PHQ 9) and Alcohol Use Disorders Identification Test (AUDIT)), as well as gender and income characteristics. The PSS identified an increased level of perceived stress in female students, in contrast, the AUDIT showed an increased level of alcohol use disorders in male students. Differences in mental and behavioural disorders between the gender and income categories were significant in most of the analysed cases. In terms of gender-income characteristics, it was possible to confirm a significant positive effect of the PSS score on the PHQ 9 score, as well as a significant positive effect of the PHQ 9 score on the AUDIT score. As a result, efforts to reduce stress will be reflected in a reduction of depressive disorders as well as a reduction of excessive alcohol consumption among students.

scholarly journals Relationships between Perceived Stress, Depression and Alcohol Use Disorders in University Students during the COVID-19 Pandemic: A Socio-Economic Dimension

2020 ◽  
Vol 17 (23) ◽  
pp. 8853
Author(s):  
Beata Gavurova ◽  
Viera Ivankova ◽  
Martin Rigelsky
Keyword(s):  
Alcohol Use ◽  
University Students ◽  
Perceived Stress ◽  
Depressive Disorders ◽  
Alcohol Use Disorders ◽  
Diagnostic Tools ◽  
Significant Positive Effect ◽  
Excessive Alcohol Consumption ◽  
Economic Dimension ◽  
Positive Effect

The objective of the study was to examine the effects of perceived stress on depression and subsequently to examine the effects of depression on alcohol use disorders. The data were obtained by an electronic questionnaire survey during the coronavirus disease 2019 (COVID-19) pandemic (n = 1523 Slovak university students). Descriptive, regression, and correlation analysis were used in the analytical processing, while the analyses included students’ scores in three diagnostic tools (Perceived Stress Scale (PSS), Patient Health Questionnaire for depression (PHQ 9), and Alcohol Use Disorders Identification Test (AUDIT)), as well as gender and income characteristics. The PSS identified an increased level of perceived stress in female students, while in contrast, the AUDIT showed an increased level of alcohol use disorders in male students. Differences in mental and behavioural disorders between the gender and income categories were significant in most of the analysed cases. In terms of gender-income characteristics, it was possible to confirm a significant positive effect of the PSS score on the PHQ 9 score, as well as a significant positive effect of the PHQ 9 score on the AUDIT score. As a result, efforts to reduce stress will be reflected in a reduction of depressive disorders as well as a reduction of excessive alcohol consumption among students.

743 Differences in the prevalence of sleep disturbance and associated risk factors in alcohol use disorders and major depression

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A290-A290
Author(s):  
Bhanu Prakash Kolla ◽  
Brandon Coombes ◽  
Meghna Mansukhani ◽  
Joanna Biernacka
Keyword(s):  
Risk Factors ◽  
Alcohol Use ◽  
Sleep Disturbance ◽  
Sleep Duration ◽  
Depressive Disorders ◽  
Large Population ◽  
Alcohol Use Disorders ◽  
Control Sample ◽  
Sleep Disruption ◽  
Diagnostic Categories

Abstract Introduction Sleep disruption is common in patients with alcohol use disorders (AUD) and major depressive disorders (MDD). Our understanding of the differences in the rates of sleep disturbance and overall sleep duration in patients with AUD, MDD, and comorbid AUD and MDD is limited. Furthermore, it is unknown whether there is variation in demographic and clinical characteristics associated with sleep disturbance and duration in these diagnostic groups. Methods This study utilized data from the UK Biobank (UKB). Depression status was determined based on review of International Classification of Diseases (ICD) codes and health records. AUD status was based on AUDIT scores (score ≥8 was defined as AUD) and sleep disturbance was evaluated utilizing a self-reported questionnaire. The sample was categorized into those with MDD alone (MDD+/AUD-)(n=18,154), AUD alone (MDD-/AUD+)(n=6123), both (MDD+/AUD+)(n=9027), and controls with neither (MDD-/AUD-)(n=27,573). We used generalized linear models (GLMs) to compare rates of sleep disruption and duration among the groups and determine the clinical predictors of sleep disturbance/duration in the four groups as well as test whether these factors differed among the groups. Results The prevalence of sleep disturbance in the control sample (MDD-/AUD-) was 26.4% and the self-reported sleep duration in this sample was 7.209±0.919. Subjects with AUD and/or MDD had greater rates of sleep disturbance and shorter sleep duration. Among the different diagnostic categories, the prevalence of sleep disturbance was highest in subjects with MDD+/AUD+ (36.5%) followed by those with MDD+/AUD- (35.6%) and MDD-/AUD+ (27.9%)(all p<0.0001). Similarly, the sleep duration was shortest in subjects with MDD+/AUD+ (7.143±1.016), followed by MDD+/AUD- (7.158±1.050) and by MDD-/AUD+ (7.202±0.891)(all p<0.0001). Subjects with sleep disturbance were more likely to be older, female, and with higher body mass index, Townsend deprivation index, and neuroticism scores across all four groups (all p<0.05). Conclusion In a large population-based cohort, MDD with and without comorbid AUD was associated with greater rates of sleep disturbance and shorter sleep duration than AUD alone. The clinical and demographic factors associated with sleep disturbance did not differ in these diagnostic categories, indicating possible similar underlying risk factors. Support (if any) NA

scholarly journals Predictors of first incidence of alcohol use disorders in the Lundby cohort from 1947-1997

2014 ◽  
Vol 3 (4) ◽  
pp. 257-267
Author(s):  
Cecilia Mattisson ◽  
Mats Bogren ◽  
Vibeke Horstmann ◽  
Leif Öjesjö
Keyword(s):  
Alcohol Use ◽  
Middle Class ◽  
Working Class ◽  
Depressive Disorders ◽  
Cox Regression ◽  
Economic Status ◽  
Alcohol Use Disorders ◽  
Incidence Rates ◽  
Field Investigations ◽  
Incidence Studies

Mattisson, C., Bogren, M., Horstmann, V., & Öjesjö, L. (2014). Predictors of first incidence of alcohol use disorders in the Lundby cohort from 1947-1997. The International Journal Of Alcohol And Drug Research, 3(4), 257-267. doi:http://dx.doi.org/10.7895/ijadr.v3i4.185Objective: Epidemiological evidence indicates an inverse relationship between socio-economic status (SES) and alcohol use disorder (AUD), although there are relatively few recent incidence studies. The present study aimed to assess the incidence of AUD by age, gender and SES and to analyse AUD’s association with mental disorder.Method: Information about mental disorders, including first incidence cases of AUD, was assessed in the Lundby cohort (n=3,563) by field investigations in 1947, 1957, 1972 and 1997. Incidence calculations were based on 3,372 individuals without prior AUD. For the two genders, age-standardised incidences of AUD for the 25-year periods of 1947-1972 and 1972-1997 were compared. Possible risk factors for incident AUD were analysed by means of Cox regression analyses for the whole sample and for each sex separately.Results: A total of 233 first incidence AUD cases were detected (198 males, 35 females. Incidence rates, expressed as number of cases per 1000 person years, were highest for working class males at 5.46 cases per 1000 person years for the period 1 of July 1947, to 30 June 1972 and 4.77 for the period 1 of July 1972 to 30 June 1997, respectively. Middle class males showed intermediate incidence rates of 2.73 and 2.65. Self-employed males showed the lowest incidence rates of 2.50 and 1.47. Females generally had much lower incidence, although they showed a non-significant tendency for higher incidence rates in the latter period. A diagnosis of depressive disorders, anxiety disorders and unspecific neurotic states increased the risk for developing first incident AUD.Conclusion: Working class males had higher annual incidence of alcoholism in both time periods relative to middle class and self-employed males. Mental disorder increased the risk for AUD among both genders.

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