Level of physicians' awareness of antiepileptic drug adverse effects

2018 ◽  
Vol 89 ◽  
pp. 59-62
Author(s):  
Ameen Mosleh Almohammadi ◽  
Ruqayah Mohamed Huzaim
Keyword(s):  
Adverse Effects ◽  
Antiepileptic Drug ◽  
Drug Adverse Effects

Antiepileptic Drug Adverse Effects

Epilepsy ◽  
2014 ◽  
pp. 84-90
Author(s):  
Jacquelyn L. Bainbridge ◽  
Caleb Y. Oh
Keyword(s):  
Adverse Effects ◽  
Antiepileptic Drug ◽  
Drug Adverse Effects

scholarly journals Treatment of epilepsy – towards precision

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1932 ◽  
Author(s):  
John Paul Leach
Keyword(s):  
Genetic Testing ◽  
Adverse Effects ◽  
Drug Treatment ◽  
Antiepileptic Drug ◽  
Precision Medicine ◽  
Treatment Of Epilepsy ◽  
Antiepileptic Drug Treatment

Epilepsy was among the first disease areas to begin to apply principles of precision medicine to its treatment. This review looks at the role of investigation in ensuring the safety and effectiveness of antiepileptic drug treatment. Using sound principles, we can see that the use of genetic testing will advance treatment of epilepsy in reducing harm and adverse effects and enhancing efficacy.

scholarly journals Clinically relevant drug‐drug interactions and the risk for drug adverse effects among home‐dwelling older persons with and without type 2 diabetes

2019 ◽  
Vol 44 (5) ◽  
pp. 735-741 ◽  
Author(s):  
Ilona Ikäheimo ◽  
Merja Karjalainen ◽  
Miia Tiihonen ◽  
Maija Haanpää ◽  
Hannu Kautiainen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adverse Effects ◽  
Drug Interactions ◽  
Older Persons ◽  
Drug Adverse Effects

Zonisamide

2018 ◽  
Author(s):  
Andrea E. Cavanna
Keyword(s):  
Bipolar Disorder ◽  
Weight Gain ◽  
Adverse Effects ◽  
Alcohol Dependence ◽  
Antiepileptic Drug ◽  
Preliminary Evidence ◽  
Tolerability Profile ◽  
Patients With Epilepsy ◽  
Psychiatric Adverse Effects ◽  
Acceptable Tolerability Profile

Zonisamide is a second-generation antiepileptic drug characterized by a few antiepileptic indications, with an acceptable interaction profile in polytherapy. Zonisamide has an acceptable tolerability profile in patients with epilepsy, with depression, irritability, agitation and psychosis as the most commonly reported psychiatric adverse effects. Zonisamide has no approved indications or clinical uses in psychiatry, as initial findings from uncontrolled studies suggesting effectiveness in the treatment of patients with bipolar disorder did not find confirmation. There is preliminary evidence for possible usefulness of zonisamide in the treatment of patients with obesity and psychotropic-associated weight gain, as well as alcohol dependence and withdrawal.

Vigabatrin

2018 ◽  
Author(s):  
Andrea E. Cavanna
Keyword(s):  
Adverse Effects ◽  
Antiepileptic Drug ◽  
Routine Clinical Practice ◽  
Visual Field Defects ◽  
Tolerability Profile ◽  
Psychiatric History ◽  
Weak Evidence ◽  
Patients With Epilepsy ◽  
Psychiatric Adverse Effects ◽  
Field Defects

Vigabatrin is a second-generation antiepileptic drug characterized by a few antiepileptic indications, with a very good interaction profile in polytherapy. Clinically relevant adverse effects (especially visual field defects) have reduced its use as antiepileptic drug in routine clinical practice considerably. Vigabatrin has an acceptable behavioural tolerability profile, although patients with epilepsy treated with this medication can report depression, psychosis, and irritability. Risk factors for developing psychiatric adverse effects include high starting and maintenance doses, past psychiatric history, and epilepsy severity. Vigabatrin has no approved indications or clinical uses in psychiatry, despite weak evidence for its usefulness in the treatment of anxiety disorders and addictions.

Generating signals of drug-adverse effects from prescription databases and application to the risk of arrhythmia associated with antibacterials

2004 ◽  
Vol 14 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Giovanni Corrao ◽  
Edoardo Botteri ◽  
Vincenzo Bagnardi ◽  
Antonella Zambon ◽  
Alessandra Carobbio ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Drug Adverse Effects ◽  
Prescription Databases

Developmental Principles of Antiepileptic Drug Therapy

1994 ◽  
Vol 9 (1_suppl) ◽  
pp. S20-S25 ◽  
Author(s):  
Jamie T. Gilman
Keyword(s):  
Drug Therapy ◽  
Adverse Effects ◽  
Antiepileptic Drug ◽  
Drug Disposition ◽  
Drug Effects ◽  
Drug Clearance ◽  
Developmental Differences ◽  
Close Monitoring ◽  
Drug Concentrations ◽  
Antiepileptic Drug Therapy

Antiepileptic drug therapy in children can be challenging because seizure semiology and drug disposition change dramatically over time. Close monitoring of drug clearance is required in early life because of the rapid ontogenesis of drug-eliminating organs. Large variations in serum peak and trough antiepileptic drug concentrations increase the risk for both adverse drug effects and unsatisfactory seizure control. Antiepileptic drug adverse effects also differ, probably relative to different receptor sensitivities in children. Failure to appreciate the developmental differences between children and adults can result in medication noncompliance, breakthrough seizures, and unacceptable adverse effects. (J Child Neurol 1994;9(Suppl):S20-S25).

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