Generating signals of drug-adverse effects from prescription databases and application to the risk of arrhythmia associated with antibacterials

2004 ◽  
Vol 14 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Giovanni Corrao ◽  
Edoardo Botteri ◽  
Vincenzo Bagnardi ◽  
Antonella Zambon ◽  
Alessandra Carobbio ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Drug Adverse Effects ◽  
Prescription Databases

Level of physicians' awareness of antiepileptic drug adverse effects

2018 ◽  
Vol 89 ◽  
pp. 59-62
Author(s):  
Ameen Mosleh Almohammadi ◽  
Ruqayah Mohamed Huzaim
Keyword(s):  
Adverse Effects ◽  
Antiepileptic Drug ◽  
Drug Adverse Effects

scholarly journals Clinically relevant drug‐drug interactions and the risk for drug adverse effects among home‐dwelling older persons with and without type 2 diabetes

2019 ◽  
Vol 44 (5) ◽  
pp. 735-741 ◽  
Author(s):  
Ilona Ikäheimo ◽  
Merja Karjalainen ◽  
Miia Tiihonen ◽  
Maija Haanpää ◽  
Hannu Kautiainen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adverse Effects ◽  
Drug Interactions ◽  
Older Persons ◽  
Drug Adverse Effects

scholarly journals Impurities and Drug Adverse Effects

1998 ◽  
Vol 21 (1) ◽  
pp. 60-62
Author(s):  
Chitharanjan Andrade
Keyword(s):  
Adverse Effects ◽  
Drug Adverse Effects

scholarly journals Study of adverse drug reaction and causality assessment of antidiabetic drugs

2018 ◽  
Vol 8 (1) ◽  
pp. 56
Author(s):  
Shanthi M. ◽  
Madhavrao C.
Keyword(s):  
Adverse Effect ◽  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Adverse Effects ◽  
Tertiary Care ◽  
Antidiabetic Drugs ◽  
Care Hospital ◽  
Drug Adverse Effects ◽  
Relationship Of ◽  
Effects Assessment

Background: Study about adverse drug reaction of antidiabetic drugs helps in ensuring maximum benefits of drug therapy.Methods: An observational study was carried out in patients attending tertiary care hospital in Kanyakumari district from August 2013 to August 2014. Adverse drug reactions due to the use of antidiabetic drugs were collected and adverse effects experienced by the patient was assessed using WHO scale, Naranjo scale, Schumock and Thornton scale and Hartwig and Siegel scale.Results: In this prospective study a total of 76 adverse events (41 male and 35 female) were identified. Most frequently observed adverse effect were hypoglycaemia and the less observed were pruritis. Maximum of 14 adverse effect were observed due to use of insulin. Combination of sulphonylurea and biguanides caused 28 adverse effects. Assessment of adverse effect using WHO scale showed 64% as probable, 16% possible, 7% conditional, 5% unclassifiable, 4% certain, and 4% unlikely. Relationship of adverse reaction to antidiabetic drugs using Naranjo scale showed 92% possibly, 5% probably and 3% as definite. Antidiabetic drug adverse effects were not preventable in 63%, definitely preventable in 19% and probably preventable in 18% as per modified Schumock and Thornton scale. Severity assessment of adverse effects were mild in 75%, moderate in 25% and no severe reactions according to modified Hartwig and Siegel scale.Conclusions: Adverse effect most commonly encountered during the study period were predictable, definitely preventable and without serious effects. Majority of the reactions were due to combination of antidiabetic drugs.

scholarly journals Evaluation of Medline Utility for the Retrieval of Case Reports of Drug Adverse Effects.

2000 ◽  
Vol 26 (1) ◽  
pp. 27-35
Author(s):  
JUN HAMADA ◽  
TAKAO ORII ◽  
ETSUKO NEGISHI ◽  
YASUHIKO YAMADA ◽  
HITOSHI SATO ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Case Reports ◽  
Drug Adverse Effects

Urate-lowering therapy agents

2016 ◽  
Author(s):  
Nicola Dalbeth
Keyword(s):  
Adverse Effects ◽  
Combination Therapy ◽  
Xanthine Oxidase ◽  
Hepatic Impairment ◽  
Serum Urate ◽  
First Line ◽  
Lowering Therapy ◽  
Uricosuric Agents ◽  
Drug Adverse Effects

Xanthine oxidase (allopurinol or febuxostat) is considered first-line urate-lowering therapy. Combination therapy with uricosuric agents may be required. The choice of urate-lowering therapy is dictated by co-morbidities, particularly renal and hepatic impairment. Appropriate monitoring for drug adverse effects as well as serum urate to ensure targets are achieved is required.

US Food and Drug Administration Black Box Warnings

2020 ◽  
Vol 110 (1) ◽  
Author(s):  
Robert G. Smith
Keyword(s):  
Adverse Effects ◽  
Drug Administration ◽  
Food And Drug Administration ◽  
Black Box ◽  
Ethical Obligation ◽  
Drug Products ◽  
Body Of Knowledge ◽  
Drug Adverse Effects ◽  
Black Box Warnings ◽  
Selection Of

Podiatric Physicians have an ethical obligation to prescribe responsibly and cautiously to diminish and minimize the growth of drug adverse effects. Clinicians who prescribe, dispense, and administer medications must be vigilant in continually reviewing new Black Box Warnings for medications they use for their patients. The safe and appropriate selection of medications and prescribing strategies are presented. First, the concept and process for these FDA black box warnings are introduced. Then, to enrich the podiatric physician's body of knowledge, several FDA boxed warnings from 27 selected drug products that may be prescribed by podiatric physicians are presented graphically as a table. Finally, strategies for safe prescribing of these drugs with boxed warnings are presented.

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