scholarly journals Mapping the neuropsychological profile of temporal lobe epilepsy using cognitive network topology and graph theory

2016 ◽  
Vol 63 ◽  
pp. 9-16 ◽  
Author(s):  
Tanja S. Kellermann ◽  
Leonardo Bonilha ◽  
Ramin Eskandari ◽  
Camille Garcia-Ramos ◽  
Jack J. Lin ◽  
...  
Keyword(s):  
Graph Theory ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Network Topology ◽  
Cognitive Network ◽  
Neuropsychological Profile ◽  
Topology And Graph Theory

scholarly journals Presurgery resting-state local graph-theory measures predict neurocognitive outcomes after brain surgery in temporal lobe epilepsy

Epilepsia ◽  
2015 ◽  
Vol 56 (4) ◽  
pp. 517-526 ◽  
Author(s):  
Gaelle E. Doucet ◽  
Robert Rider ◽  
Nathan Taylor ◽  
Christopher Skidmore ◽  
Ashwini Sharan ◽  
...  
Keyword(s):  
Graph Theory ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Resting State ◽  
Brain Surgery ◽  
Neurocognitive Outcomes ◽  
Local Graph

scholarly journals Neuronal morphology and physiology, functional brain networks and memory in temporal lobe epilepsy

2021 ◽  
Author(s):  
Linda Douw ◽  
Ida A. Nissen ◽  
Sophie M.D.D. Fitzsimmons ◽  
Fernando A.N. Santos ◽  
Arjan Hillebrand ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Network Topology ◽  
Memory Performance ◽  
Neuronal Morphology ◽  
Middle Temporal Gyrus ◽  
Memory Functioning ◽  
Dendritic Length ◽  
Macro Scale ◽  
Canonical Correlation Coefficient

ABSTRACTTemporal lobe epilepsy patients are heterogeneous regarding cognitive functioning, with predominant risk of memory deficits. Despite major advances within cellular neuroscience, neuroimaging, and neuropsychology, it remains challenging to integrate memory performance with cellular characteristics and brain network topology. In a unique dataset, we investigate these cross-scale individual differences. Preoperatively, drug-resistant temporal lobe epilepsy patients (n = 31, 15 females) underwent functional magnetic resonance imaging, magnetoencephalography and/or memory testing. Macro-scale network centrality was determined, since the number of integrative functional connections a region has is crucial for memory functioning. Subsequently, non-pathological cortical tissue resected from the lateral middle temporal gyrus (default mode network) was used for single cell morphological (total dendritic length) and electrophysiological patch-clamp analysis (action potential rise speed). We expected greater macro-scale centrality to relate to longer micro-scale dendritic length and faster action potentials, and greater centrality to relate to better memory performance. Greater macro-scale centrality correlated with longer dendritic length and faster action potentials (canonical correlation coefficient = 0.329, p < 0.001). Moreover, greater macro-scale centrality was related to better memory performance (canonical correlation coefficient = 0.234, p = 0.013). We conclude that more complex neuronal morphology and faster action potential kinetics are mirrored by more integrative functional network topology of the middle temporal gyrus, which in turn is associated with better memory functioning. Thus, our cross-scale analyses reveal a significant relationship between cellular and imaging measures of network topology in the brain, which support cognitive performance in these patients.

Neuropsychological profile of mild temporal lobe epilepsy

2018 ◽  
Vol 85 ◽  
pp. 222-226 ◽  
Author(s):  
Maria Grazia Vaccaro ◽  
Michele Trimboli ◽  
Cristina Scarpazza ◽  
Liana Palermo ◽  
Antonella Bruni ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Neuropsychological Profile

scholarly journals Subregional Mesiotemporal Network Topology Is Altered in Temporal Lobe Epilepsy

2015 ◽  
Vol 26 (7) ◽  
pp. 3237-3248 ◽  
Author(s):  
Boris C. Bernhardt ◽  
Neda Bernasconi ◽  
Seok-Jun Hong ◽  
Sebastian Dery ◽  
Andrea Bernasconi
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Network Topology

scholarly journals Metabolic covariance networks combining graph theory measuring aberrant topological patterns in mesial temporal lobe epilepsy

2018 ◽  
Vol 25 (3) ◽  
pp. 396-408 ◽  
Author(s):  
Kai-Liang Wang ◽  
Wei Hu ◽  
Ting-Hong Liu ◽  
Xiao-Bin Zhao ◽  
Chun-Lei Han ◽  
...  
Keyword(s):  
Graph Theory ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Mesial Temporal Lobe Epilepsy ◽  
Mesial Temporal Lobe
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