New observations in primary and secondary reading epilepsy: Excellent response to levetiracetam and early spontaneous remission

2012 ◽  
Vol 23 (4) ◽  
pp. 466-470 ◽  
Author(s):  
M. Ayman Haykal ◽  
Amro El-Feki ◽  
Hasan H. Sonmezturk ◽  
Bassel W. Abou-Khalil
Keyword(s):  
Spontaneous Remission ◽  
Secondary Reading ◽  
Excellent Response

Spontaneous remission in diabetes

JAMA ◽  
1966 ◽  
Vol 196 (12) ◽  
pp. 1085b-1085
Keyword(s):  
Spontaneous Remission

Excellent Response to Hydroxychloroquine in a Young Man with Lupus Erythematosus Panniculitis

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Parigini Aníbal María ◽  
Diego María Clara de ◽  
Beguerie Julieta Ruiz ◽  
Paredes Victoria Duran ◽  
Anaya Javier
Keyword(s):  
Lupus Erythematosus ◽  
Excellent Response ◽  
Lupus Erythematosus Panniculitis

scholarly journals The role of Hashimoto thyroiditis in predicting radioiodine ablation efficacy and prognosis of low to intermediate risk differentiated thyroid cancer

2021 ◽  
Author(s):  
Domenico Albano ◽  
Francesco Dondi ◽  
Valentina Zilioli ◽  
Maria Beatrice Panarotto ◽  
Alessandro Galani ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Treatment Response ◽  
Differentiated Thyroid Cancer ◽  
Hashimoto Thyroiditis ◽  
Prognostic Impact ◽  
Intermediate Risk ◽  
Excellent Response ◽  
Radioiodine Ablation ◽  
One Year

Abstract Objective The baseline treatment of differentiated thyroid cancer (DTC) consists of thyroidectomy followed by postoperative risk-adapted radioiodine therapy (RAIT) when indicated. The choice of most appropriate RAI activities to administer with the aim to reach an efficient remnant ablation and reduce the risk of recurrence is yet an open issue and the detection of basal factors that may predict treatment response seems fundamental. The aim of this study was to investigate the potential role of Hashimoto thyroiditis (HT) in predicting 1-year and 5-year treatment response after RAIT and prognosis. Methods We retrospectively included 314 consecutive patients (174 low-risk and 140 intermediate-risk) who received thyroidectomy plus RAIT. One-year and 5-year disease status was evaluated according to 2015 ATA categories response based upon biochemical and structural findings. Results HT was reported histopathologically in 120 patients (38%). DTC patients with concomitant HT received a higher number of RAITs and cumulative RAI activities. Initial RAIT reached an excellent response in 63% after one year and 84% after 5 years. The rate of excellent response one year and 5-year after first RAIT was significantly lower in HT groups, compared to not HT (p < 0.001). Instead, HT did not have a prognostic role considering PFS and OS; while stimulate thyroglobulin (sTg) at ablation was significantly related to survival. Conclusions HT may affect the efficacy of RAIT in low to intermediate risk DTC, particularly reducing the successful rate of excellent response after RAIT. Instead, HT did not have a prognostic impact such as stimulated sTg.

scholarly journals Addiction as a brain disease revised: why it still matters, and the need for consilience

2021 ◽  
Author(s):  
Markus Heilig ◽  
James MacKillop ◽  
Diana Martinez ◽  
Jürgen Rehm ◽  
Lorenzo Leggio ◽  
...  
Keyword(s):  
Spontaneous Remission ◽  
Brain Disease ◽  
Substance Addiction ◽  
Alternative Reinforcement ◽  
Sociocultural Perspectives ◽  
Compulsive Behaviors ◽  
Biological Substrate ◽  
Neural Signature ◽  
The Brain ◽  
Neuroscience Community

AbstractThe view that substance addiction is a brain disease, although widely accepted in the neuroscience community, has become subject to acerbic criticism in recent years. These criticisms state that the brain disease view is deterministic, fails to account for heterogeneity in remission and recovery, places too much emphasis on a compulsive dimension of addiction, and that a specific neural signature of addiction has not been identified. We acknowledge that some of these criticisms have merit, but assert that the foundational premise that addiction has a neurobiological basis is fundamentally sound. We also emphasize that denying that addiction is a brain disease is a harmful standpoint since it contributes to reducing access to healthcare and treatment, the consequences of which are catastrophic. Here, we therefore address these criticisms, and in doing so provide a contemporary update of the brain disease view of addiction. We provide arguments to support this view, discuss why apparently spontaneous remission does not negate it, and how seemingly compulsive behaviors can co-exist with the sensitivity to alternative reinforcement in addiction. Most importantly, we argue that the brain is the biological substrate from which both addiction and the capacity for behavior change arise, arguing for an intensified neuroscientific study of recovery. More broadly, we propose that these disagreements reveal the need for multidisciplinary research that integrates neuroscientific, behavioral, clinical, and sociocultural perspectives.

Sign in / Sign up

Export Citation Format

Share Document