scholarly journals Evaluation of inner retinal function in myopia using oscillatory potentials of the multifocal electroretinogram

2006 ◽  
Vol 46 (24) ◽  
pp. 4096-4103 ◽  
Author(s):  
Jennifer C. Chen ◽  
Brian Brown ◽  
Katrina L. Schmid
Keyword(s):  
Multifocal Electroretinogram ◽  
Oscillatory Potentials ◽  
Retinal Function

scholarly journals Electrophysiological Monitoring of Focal and Entire Retinal Function during Treatment with Intravitreal Methotrexate for Intraocular Lymphoma

2021 ◽  
pp. 277-282
Author(s):  
Takashi Matsushima ◽  
Yuji Yoshikawa ◽  
Airi Shimura ◽  
Ayana Yajima ◽  
Yui Ojima ◽  
...  
Keyword(s):  
Multifocal Electroretinogram ◽  
Malignant Lesion ◽  
Central Area ◽  
Interleukin 10 ◽  
High Ratio ◽  
Retinal Function ◽  
Intraocular Lymphoma ◽  
Blurred Vision ◽  
Macular Function ◽  
Skin Electrodes

We describe the electroretinographic findings of a case of primary intraocular lymphoma (PIOL) wherein the patient received intravitreal injections of methotrexate (ivMTX). A 62-year-old man developed blurred vision and complained of decreased visual acuity (VA) in his right eye. Fundus examination showed vitreous opacity and multiple subretinal yellowish lesions. Optical coherence tomography (OCT) revealed subretinal and intraretinal infiltrations. The full-field electroretinogram (ffERG) showed subnormal combined rod-cone response and multifocal electroretinogram (mfERG) recorded using skin electrodes showed severe attenuation of the response compared with the other eye. Pars prana vitrectomy, phacoemulsification, and lens implantation were performed to remove the opacity, and vitreous biopsy revealed a high ratio of interleukin 10–6 (76.0). There was no systemic malignant lesion, and the patient was diagnosed with PIOL. Treatment with ivMTX (400 μg/0.1 mL) was started. One month later, the intraretinal infiltration had disappeared, and mfERG revealed recovery of the response density from the central area. Two months later, OCT showed recovery of the foveal ellipsoid and interdigitation zones, and VA recovered to 20/17; mfERG showed maintenance of macular function. However, the amplitude of a- and b-waves in the ffERG gradually decreased. Macular function recovered, but there was also a decrease in total retinal function. mfERG and ffERG recorded using skin electrodes were useful in monitoring macular and entire retinal function with repeated examinations and showed recovery and maintenance of macular function in a case of PIOL treated with ivMTX.

Retinal Function in Normal and Diabetic Eyes Mapped with the Slow Flash Multifocal Electroretinogram

2004 ◽  
Vol 45 (1) ◽  
pp. 296 ◽  
Author(s):  
Marcus A. Bearse ◽  
Ying Han ◽  
Marilyn E. Schneck ◽  
Anthony J. Adams
Keyword(s):  
Multifocal Electroretinogram ◽  
Retinal Function

S-Adenosyl-l-methionine restores photoreceptor function following acute retinal ischemia

2009 ◽  
Vol 26 (5-6) ◽  
pp. 429-441 ◽  
Author(s):  
LEITH MOXON-LESTER ◽  
KEI TAKAMOTO ◽  
PAUL B. COLDITZ ◽  
NIGEL L. BARNETT
Keyword(s):  
Creatine Kinase ◽  
Ischemia Reperfusion ◽  
Oscillatory Potentials ◽  
Retinal Ischemia ◽  
Creatine Kinase Activity ◽  
Retinal Function ◽  
Ischemic Insult ◽  
Adult Rats ◽  
Neuroprotective Strategy ◽  
And Function

AbstractThe survival and function of retinal neurons is dependent on mitochondrial energy generation and its intracellular distribution by creatine kinase. Post ischemic disruption of retinal creatine synthesis, creatine kinase activity, or transport of creatine into neurons may impair retinal function. S-adenosyl-l-methionine (SAMe) is required for creatine synthesis, phosphatidylcholine and glutathione synthesis, and transducin methylation. These reactions are essential for photoreceptor function but may be downregulated after ischemia due to a reduction in SAMe. Our aim was to determine whether administration of SAMe after ischemia could improve retinal function. Unilateral retinal ischemia was induced in adult rats by increasing the intraocular pressure to 110 mm Hg for 60 min. Immediately after the ischemic insult, SAMe was injected into the vitreous (100μm), followed by oral administration (69 mg/kg/day) for 5 or 10 days. Retinal function (electroretinography), histology, and creatine transporter (CRT-1) expression were analyzed. Photoreceptoral responses (RmP3,S), rod and cone bipolar cell responses (PII), and oscillatory potentials were reduced by the ischemia/reperfusion insult. Although SAMe treatment ameliorated the ischemia-induced histological damage by day 5, there was no improvement in retinal function and the intensity of CRT-1 labeling in ischemic retinas was markedly reduced. However, 10 days after ischemia, a recovery in CRT-1 immunolabeling was evident and SAMe supplementation significantly restored photoreceptor function and rod PII responses. In conclusion, these data suggest that creatine transport and methylation reactions, such as creatine synthesis, may be compromised by an ischemic insult contributing to retinal dysfunction and injury. Oral SAMe supplementation after retinal ischemia may provide an effective, safe, and accessible neuroprotective strategy.

Multifocal and full-field electroretinogram changes associated with color-vision loss in mercury vapor exposure

2004 ◽  
Vol 21 (3) ◽  
pp. 421-429 ◽  
Author(s):  
DORA F. VENTURA ◽  
MARCELO T.V. COSTA ◽  
MARCELO F. COSTA ◽  
ADRIANA BEREZOVSKY ◽  
SOLANGE R. SALOMÃO ◽  
...  
Keyword(s):  
Color Vision ◽  
Vision Loss ◽  
Color Discrimination ◽  
Mercury Vapor ◽  
Oscillatory Potentials ◽  
Retinal Function ◽  
Mercury Contamination ◽  
Central Field ◽  
Full Field ◽  
Color Vision Loss

We evaluated the color vision of mercury-contaminated patients and investigated possible retinal origins of losses using electroretinography. Participants were retired workers from a fluorescent lamp industry diagnosed with mercury contamination (n= 43) and age-matched controls (n= 21). Color discrimination was assessed with the Cambridge Colour Test (CCT). Retinal function was evaluated by using the ISCEV protocol for full-field electroretinography (full-field ERG), as well as by means of multifocal electroretinography (mfERG). Color-vision losses assessed by the CCT consisted of higher color-discrimination thresholds along the protan, deutan, and tritan axes and significantly larger discrimination ellipses in mercury-exposed patients compared to controls. Full-field ERG amplitudes from patients were smaller than those of the controls for the scotopic responseb-wave, maximum response, sum of oscillatory potentials (OPs), 30-Hz flicker response, and light-adapted cone response. OP amplitudes measured in patients were smaller than those of controls for O2 and O3. Multifocal ERGs recorded from ten randomly selected patients showed smaller N1–P1 amplitudes and longer latencies throughout the 25-deg central field. Full-field ERGs showed that scotopic, photopic, peripheral, and midperipheral retinal functions were affected, and the mfERGs indicated that central retinal function was also significantly depressed. To our knowledge, this is the first demonstration of retinal involvement in visual losses caused by mercury toxicity.

scholarly journals Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Jiang Huang ◽  
Yi Li ◽  
Jianjiang Xiao ◽  
Qin Zhang ◽  
Guoxu Xu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multifocal Electroretinogram ◽  
Retinal Function ◽  
Spectral Domain ◽  
Implicit Time ◽  
Diagnostic Efficacy ◽  
Macular Volume ◽  
Amplitude Density ◽  
Sd Oct

Background. The retinal changes have been identified in morphology and function in Parkinson’s disease (PD). However, the controversial results suggest that it is incredible that only using a single method for testing retinal change to evaluate Parkinson’s disease. The aim of this study was to assess retinal changes and increase the diagnostic efficacy of Parkinson’s disease with a combination of multifocal electroretinogram (mf-ERG) and spectral domain optical coherence tomography (SD-OCT) examinations. Method. Fifty-three PD patients and forty-one healthy controls were enrolled. Subjects were assessed for retinal function using mf-ERG and retinal structure using SD-OCT. Results. The PD patients had a significantly decreased amplitude density of P1 and a delayed implicit time of P1 in some regions. The macular retinal thickness, macular volume, and average RNFL thickness were decreased in PD. The AUC of a single parameter of either retinal function or structure was low. Both of them were higher in diagnostic value to discriminate PD patients. Conclusion. The amplitude density of P1 combined with macular volume can get a high diagnostic efficacy to discriminate between participants with or without PD. It indicates that a combination of mf-ERG and SD-OCT provides a good clinical biomarker for diagnosis of PD.

scholarly journals The Success of Cataract Surgery and the Preoperative Measurement of Retinal Function by Electrophysiological Techniques

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jing An ◽  
Lei Zhang ◽  
Yusheng Wang ◽  
Zuoming Zhang
Keyword(s):  
Cataract Surgery ◽  
Multifocal Electroretinogram ◽  
Retinal Function ◽  
Central Point ◽  
Control Group ◽  
Relevant Parameter ◽  
Macular Function ◽  
Control Subjects ◽  
Center Point ◽  
Cataract Patients

Purpose. To study the effect of different electrophysiological methods to evaluate retinal function prior to cataract surgery.Methods. Cataract patients who had no significant other eye disease were chosen. VA, pattern visual evoked potential (PVEP), electroretinogram (ERG), and multifocal electroretinogram (mfERG) responses were measured from 150 cataract patients and 20 control subjects.Results. When the preoperative VA was more than 0.3 in cataract patients, the amplitude of PVEP was not significantly different between cataract and control subjects. The amplitude of central point mfERG was significantly lower in cataract patients compared with control group from HM to 0.8 of preoperative VA. The 95% confidence intervals (CIs) of the amplitudes of center point mfERG were calculated for a range of preoperative VA values. Most of the patients within 95% CI of the center point mfERG had a postoperative VA more than 0.5.Conclusions. The amplitude of central point mfERG in cataract patients was the most relevant parameter to the preoperative VA compared with PVEP and ERG. The 95% CI of the amplitude of central point mfERG for each level of VA could help to evaluate preoperative macular function which is used to predict the outcome of cataract surgery.

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