scholarly journals Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Jiang Huang ◽  
Yi Li ◽  
Jianjiang Xiao ◽  
Qin Zhang ◽  
Guoxu Xu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multifocal Electroretinogram ◽  
Retinal Function ◽  
Spectral Domain ◽  
Implicit Time ◽  
Diagnostic Efficacy ◽  
Macular Volume ◽  
Amplitude Density ◽  
Sd Oct

Background. The retinal changes have been identified in morphology and function in Parkinson’s disease (PD). However, the controversial results suggest that it is incredible that only using a single method for testing retinal change to evaluate Parkinson’s disease. The aim of this study was to assess retinal changes and increase the diagnostic efficacy of Parkinson’s disease with a combination of multifocal electroretinogram (mf-ERG) and spectral domain optical coherence tomography (SD-OCT) examinations. Method. Fifty-three PD patients and forty-one healthy controls were enrolled. Subjects were assessed for retinal function using mf-ERG and retinal structure using SD-OCT. Results. The PD patients had a significantly decreased amplitude density of P1 and a delayed implicit time of P1 in some regions. The macular retinal thickness, macular volume, and average RNFL thickness were decreased in PD. The AUC of a single parameter of either retinal function or structure was low. Both of them were higher in diagnostic value to discriminate PD patients. Conclusion. The amplitude density of P1 combined with macular volume can get a high diagnostic efficacy to discriminate between participants with or without PD. It indicates that a combination of mf-ERG and SD-OCT provides a good clinical biomarker for diagnosis of PD.

scholarly journals Topographic correlation between multifocal electroretinography, microperimetry, and spectral-domain optical coherence tomography of the macula in patients with birdshot chorioretinopathy

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Rubbia Afridi ◽  
Aniruddha Agarwal ◽  
Nam V. Nguyen ◽  
Muhammad Hassan ◽  
Mohammad Ali Sadiq ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Structural Changes ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Multifocal Electroretinogram ◽  
Spectral Domain ◽  
Implicit Time ◽  
Optical Coherence ◽  
Birdshot Chorioretinopathy ◽  
Sd Oct

Abstract Purpose To correlate the findings of retinal function with multifocal electroretinogram (mfERG), microperimetry (MP), and structural assessments with spectral-domain optical coherence tomography (SD-OCT) in topographically corresponding areas of the macula of patients with birdshot chorioretinopathy (BSCR). Methods Patients diagnosed with BSCR by clinical and imaging findings were included in the study. The mfERG was performed using 61 hexagon stimulus patterns grouped into 5 rings (Diagnosys Inc., USA). Individual responses [N1-P1 amplitudes in nanovolt (NV)/degree2 and P1 implicit time in milliseconds (msec)] for each hexagon in the central 3 rings (R1, 0°–2.3°; R2,2.3°–7.7°; and R3, 7.7°–12°) were obtained (19 hexagons). MP examination consisted of Polar 3–12° test with 28 points in 3 concentric rings with diameters of approximately 2.3°, 6.6°, and 11.1° from the foveal center. SD-OCT was performed using macular scans of 20° × 20°. The retinal sensitivity values on MP and thickness values of retinal layers were correlated with the responses on the mfERG for each topographically correlated hexagon. Results Sixteen eyes of eight patients were included in the study (mean age, 59.87 ± 10.01 years; range, 41–73 years). The amplitudes and the implicit times on mfERG and retinal sensitivities on MP were decreased for each of the 19 hexagons. Considering retinotopically matched points, there was correlation between the retinal sensitivities and mfERG implicit times and response amplitudes in all three rings. The thickness of the retinal pigment epithelium showed modest correlation with the mfERG parameters (ρ = 0.29; p = 0.04). The structural changes on SD-OCT, such as IS-OS disruption, were associated with changes in the mfERG trace arrays. Conclusions The structural and functional assessments in retinae of eyes with BSCR suggest that each imaging tool may be capturing unique aspects of retinal dysfunction. Multimodal imaging may allow detailed analyses of retinal damage at various corresponding loci. These findings are important when considering the use of these techniques in BSCR.

scholarly journals Profiling of Differentially Expressed MicroRNAs in Saliva of Parkinson's Disease Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Yanyan Jiang ◽  
Jing Chen ◽  
Yunchuang Sun ◽  
Fan Li ◽  
Luhua Wei ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Microarray Analysis ◽  
Target Genes ◽  
Characteristic Curve ◽  
Differentially Expressed ◽  
Diagnostic Efficacy ◽  
Mirna Microarray ◽  
Candidate Mirnas ◽  
Diagnostic Potential

Objective: This study aims to identify differentially expressed salivary miRNAs and validate the diagnostic potential for idiopathic Parkinson's disease (PD). Also, the disease specificity of candidate miRNAs was evaluated between PD, multiple system atrophy (MSA), and essential tremor (ET).Methods: We collected salivary samples from 50 PD, 20 ET, and 20 MSA patients, as well as 30 healthy controls (HCs). In the discovery phase, salivary miRNA microarray analysis was performed. In-silico analysis was used to investigate the target genes of differentially expressed miRNAs and clustered pathways. In validation phase, RT-qPCR was performed with samples from 30 PD patients and 30 HCs. Subsequently, we investigated candidate miRNAs in all recruited subjects. Receiver operating characteristic curve and Spearman correlation analysis was performed to determine diagnostic usefulness.Results: We identified 43 miRNAs that were differentially expressed between 5 PD patients and 5 HCs by miRNA microarray analysis. Computational analysis revealed the target genes were clustered in the pathways associated with ubiquitin protein ligase activity. The result of RT-qPCR showed that the miR-29a-3p and miR-29c-3p were found to be significantly downregulated (p = 0.004, p = 0.027), whereas the miR-6756-5p was significantly upregulated in 30 PD patients compared with 30 HCs (p = 0.032). The miR-29a-3p expression level in PD patients was significantly lower than ET patients (p = 0.035), but higher than MSA patients (p < 0.0001). The diagnostic efficacy reached a little higher when the combination of miR-29a-3p and miR-29c-3p.Conclusion: The miRNA combination of salivary miR-29a-3p and miR-29c-3p has potential to be a diagnostic biomarker for idiopathic PD.

scholarly journals Scanning laser polarimetry and spectral domain optical coherence tomography for the detection of retinal changes in Parkinson's disease

2015 ◽  
Vol 93 (8) ◽  
pp. e672-e677 ◽  
Author(s):  
Birthe Stemplewitz ◽  
Matthias Keserü ◽  
Diana Bittersohl ◽  
Carsten Buhmann ◽  
Christos Skevas ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Optical Coherence Tomography ◽  
Spectral Domain ◽  
Scanning Laser ◽  
Optical Coherence ◽  
Scanning Laser Polarimetry ◽  
Laser Polarimetry

Flash Electroretinography Parameters and Parkinson’s Disease

2020 ◽  
pp. 1-9
Author(s):  
Roni Netser ◽  
Docia L. Demmin ◽  
Roseanne Dobkin ◽  
Ariel Goldstein ◽  
Matthew Roché ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Photoreceptor Cell ◽  
Implicit Time ◽  
Diagnostic Tools ◽  
Strongly Correlated ◽  
Clinical Scales ◽  
Retinal Structure ◽  
Non Motor Symptoms ◽  
Structure And Activity

Background: Parkinson’s disease (PD) is known to affect retinal structure and activity. As such, retinal evaluations may be used to develop objective and possibly early PD diagnostic tools. Objective: The aim of this study was to investigate the effects of Parkinson’s disease (PD) manifestation and treatment on retinal activity. Methods: Data were collected on 21 participants diagnosed with PD, including the number of medications taken, clinical scales and flash electroretinography (fERG) measurements, under light-adapted and dark-adapted conditions. The fERG parameters measured included a-wave and b-wave amplitude and implicit time (i.e., latency). First, we investigated correlations between symptom measure scores and the fERG parameters. Next, we divided participants into two groups based on their antiparkinsonian medication load and analyzed differences between these groups’ fERG parameters. Results: fERG parameters were strongly correlated with a number of clinical variables, including motor and non-motor symptoms and age at PD onset. Photoreceptor cell implicit time was longer among participants taking one or less antiparkinsonian medication as compared to those taking two or more. However, overall there was not strong evidence of a relationship between the number of antiparkinsonian medications taken and the fERG parameters. Conclusion: Findings suggest that fERG may be a useful, non-intrusive measure of retinal, and, perhaps overall CNS function, in PD. However, additional studies in larger samples are needed to clarify this association.

scholarly journals Outer Retinal Assessment Using Spectral-Domain Optical Coherence Tomography in Patients With Alzheimer's and Parkinson's Disease

2018 ◽  
Vol 59 (7) ◽  
pp. 2768 ◽  
Author(s):  
Atsuro Uchida ◽  
Jagan A. Pillai ◽  
Robert Bermel ◽  
Aaron Bonner-Jackson ◽  
Alexander Rae-Grant ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Optical Coherence Tomography ◽  
Spectral Domain ◽  
Optical Coherence

scholarly journals CHANGES IN THE MICROSTRUCTURE AND FUNCTION OF BRAIN TISSUE IN PD BY DIFFUSION KURTOSIS IMAGING

2021 ◽  
Author(s):  
LEI WANG ◽  
XIN LIU ◽  
SHUOHUA WU ◽  
FANG CHEN ◽  
YE ZHENG ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Rating Scale ◽  
Early Stage ◽  
Roc Curves ◽  
Diffusion Kurtosis Imaging ◽  
Diagnostic Efficacy ◽  
Brain Microstructure ◽  
Diffusion Kurtosis

This study proposed to detect changes in brain microstructure in patients with Parkinson’s disease (PD) using diffusion kurtosis imaging (DKI) to quantitatively diagnose early-stage PD. Conventional magnetic resonance imaging and DKI scanning were performed in 24 patients with PD and in 12 age- and sex-matched healthy participants. Hoehn and Yahr (H–Y) stage and Unified Parkinson’s Disease Rating Scale-III (UPDRS-III) scores were obtained from both groups. The mean kurtosis (MK), axial kurtosis, and radial kurtosis of the bilateral substantia nigra on DKI were measured and compared between the two groups. The correlations between MK, H–Y stage, and UPDRS-III scores were determined. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy of MK for PD in the substantia nigra. The MK value in the PD group was 0.971. The area under the ROC curve of the substantia nigra was 0.905; the sensitivity and specificity were 0.917 and 0.875, respectively, and the cutoff value was 1.046. The MK of the substantia nigra in the PD group had no significant correlation with the H–Y stages but was negatively correlated with the UPDRS-III scores ([Formula: see text]; [Formula: see text]). Our research identified DKI as a novel tool for the qualitative diagnosis of PD. The optimal MK value for PD diagnosis could be determined with ROC analysis.

scholarly journals The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study

2021 ◽  
Vol Volume 15 ◽  
pp. 4005-4014
Author(s):  
Massimo Cesareo ◽  
Ernesto Di Marco ◽  
Clarissa Giannini ◽  
Matteo Di Marino ◽  
Francesco Aiello ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Posterior Pole ◽  
Early Parkinson’S Disease ◽  
Sd Oct

scholarly journals Detection of retinal changes in Parkinson's disease with spectral-domain optical coherence tomography

2010 ◽  
pp. 1427 ◽  
Author(s):  
Szilárd Kiss ◽  
Jane S. Myung ◽  
Grant D. Aaker ◽  
Claire Henchcliffe ◽  
Mujtaba Mohammed
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Optical Coherence Tomography ◽  
Spectral Domain ◽  
Optical Coherence
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