scholarly journals Influenza A virus hemagglutinin specific antibodies interfere with virion neuraminidase activity via two distinct mechanisms

Virology ◽  
2017 ◽  
Vol 500 ◽  
pp. 178-183 ◽  
Author(s):  
Ivan Kosik ◽  
Jonathan W. Yewdell
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Specific Antibodies ◽  
Neuraminidase Activity

scholarly journals Influenza A Virus H5–specific Antibodies in Mute Swans (Cygnus olor) in the USA

2015 ◽  
Vol 51 (2) ◽  
pp. 523-526 ◽  
Author(s):  
Whitney M. Kistler ◽  
David E. Stallknecht ◽  
Camille Lebarbenchon ◽  
Kerri Pedersen ◽  
David R. Marks ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Specific Antibodies ◽  
Cygnus Olor ◽  
The Usa ◽  
Mute Swans

scholarly journals The multifaceted effect of PB1-F2 specific antibodies on influenza A virus infection

Virology ◽  
2013 ◽  
Vol 447 (1-2) ◽  
pp. 1-8 ◽  
Author(s):  
I. Košík ◽  
I. Krejnusová ◽  
M. Práznovská ◽  
G. Russ
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Specific Antibodies ◽  
Influenza A Virus Infection

Studies on the Inhibitory Effect of Concanavalin A on the Neuraminidase Activity of Influenza A Virus Strains

Intervirology ◽  
1973 ◽  
Vol 2 (4) ◽  
pp. 266-269
Author(s):  
Eugene Zalan ◽  
Carl Wilson ◽  
Randall Freitag ◽  
Nicholas A. Labzoffsky
Keyword(s):  
Influenza A Virus ◽  
Concanavalin A ◽  
Influenza A ◽  
Inhibitory Effect ◽  
Neuraminidase Activity ◽  
Virus Strains

scholarly journals Virus-Coated Layer-by-Layer Colloids as a Multiplex Suspension Array for the Detection and Quantification of Virus-Specific Antibodies

2006 ◽  
Vol 52 (8) ◽  
pp. 1575-1583 ◽  
Author(s):  
Lars Toellner ◽  
Martin Fischlechner ◽  
Boris Ferko ◽  
Reingard Maria Grabherr ◽  
Edwin Donath
Keyword(s):  
Lipid Bilayer ◽  
Influenza A Virus ◽  
Influenza A ◽  
Dynamic Range ◽  
Flow Cytometric Analysis ◽  
Simultaneous Detection ◽  
Layer By Layer ◽  
Specific Antibodies ◽  
Suspension Array ◽  
Detection And Quantification

Abstract Background: Suspension array technology has surpassed ELISA for automated, simultaneous detection and quantification of soluble biomarkers such as virus-specific antibodies. We describe assays in which antigens are attached to a lipid bilayer surrounding color-coded particles. Methods: We used layer-by-layer technology to establish a multiplex suspension array with distinguishable microbeads coated with authentic viral surfaces to catch and quantify virus-specific antibodies in a flow cytometric analysis. Antigenic surfaces were generated by chimeric and wild-type baculoviruses plus 2 different influenza A virus subtypes fused to a lipid bilayer surrounding distinctly colored particles. Specificity of binding of chosen antibodies and sera was detected by immunofluorescence. Results of multiplex analysis were compared with results of ELISA. Results: Titrations of virus-specific antibodies in the multiplex suspension array demonstrated specific binding to the viral surface proteins. The multiplex suspension array gave positive results for up to log 5–diluted primary antibodies with an ∼5- to 10-fold reduced dynamic range compared with the respective ELISA. Conclusions: The bead-based multiplex suspension array is customizable and easy to establish. By displaying native influenza A virus surfaces and recombinant HIV-1 epitopes, the new assay provides a tool for the detection of major viral infections in humans.

scholarly journals Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding

2019 ◽  
Vol 8 (1) ◽  
pp. 327-338 ◽  
Author(s):  
Jimmy Chun Cheong Lai ◽  
Herath M. T. K. Karunarathna ◽  
Ho Him Wong ◽  
Joseph S. M. Peiris ◽  
John M. Nicholls
Keyword(s):  
Influenza A Virus ◽  
Receptor Binding ◽  
Influenza A ◽  
Neuraminidase Activity

The inhibitory effect of sodium baicalin on oseltamivir-resistant influenza A virus via reduction of neuraminidase activity

2018 ◽  
Vol 41 (6) ◽  
pp. 664-676 ◽  
Author(s):  
Jing Jin ◽  
Yuanjin Chen ◽  
Dechuan Wang ◽  
Lingman Ma ◽  
Min Guo ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Inhibitory Effect ◽  
Neuraminidase Activity
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