scholarly journals Antiviral activity of phage display selected peptides against Porcine reproductive and respiratory syndrome virus in vitro

Virology ◽  
2012 ◽  
Vol 432 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Ke Liu ◽  
Xiuli Feng ◽  
Zhiyong Ma ◽  
Chao Luo ◽  
Bin Zhou ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Phage Display ◽  
Respiratory Syndrome Virus

In vitro antiviral activity and underlying molecular mechanisms of dipotassium glycyrrhetate against porcine reproductive and respiratory syndrome virus

2013 ◽  
Vol 18 (8) ◽  
pp. 997-1004 ◽  
Author(s):  
Zhi-Wei Wang ◽  
Na Sun ◽  
Cai-Hong Wu ◽  
Jun-Bing Jiang ◽  
Yuan-Sheng Bai ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Molecular Mechanisms ◽  
Respiratory Syndrome Virus

scholarly journals Nitazoxanide and JIB-04 have broad-spectrum antiviral activity and inhibit SARS-CoV-2 replication in cell culture and coronavirus pathogenesis in a pig model

2020 ◽  
Author(s):  
Juhee Son ◽  
Shimeng Huang ◽  
Qiru Zeng ◽  
Traci L. Bricker ◽  
James Brett Case ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Body Weight Gain ◽  
Antiviral Agents ◽  
Cell Types ◽  
Respiratory Syndrome Virus ◽  
Transmissible Gastroenteritis Virus ◽  
Global Public Health ◽  
Dna And Rna

AbstractPathogenic coronaviruses represent a major threat to global public health. Here, using a recombinant reporter virus-based compound screening approach, we identified several small-molecule inhibitors that potently block the replication of the newly emerged severe acute respiratory syndrome virus 2 (SARS-CoV-2). Two compounds, nitazoxanide and JIB-04 inhibited SARS-CoV-2 replication in Vero E6 cells with an EC50 of 4.90 μM and 0.69 μM, respectively, with specificity indices of greater than 150. Both inhibitors had in vitro antiviral activity in multiple cell types against some DNA and RNA viruses, including porcine transmissible gastroenteritis virus. In an in vivo porcine model of coronavirus infection, administration of JIB-04 reduced virus infection and associated tissue pathology, which resulted in improved body weight gain and survival. These results highlight the potential utility of nitazoxanide and JIB-04 as antiviral agents against SARS-CoV-2 and other viral pathogens.

scholarly journals Antiviral activity of recombinant porcine surfactant protein A against porcine reproductive and respiratory syndrome virus in vitro

2016 ◽  
Vol 161 (7) ◽  
pp. 1883-1890 ◽  
Author(s):  
Lan Li ◽  
Qisheng Zheng ◽  
Yuanpeng Zhang ◽  
Pengcheng Li ◽  
Yanfeng Fu ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Respiratory Syndrome Virus

scholarly journals In vitro screening antiviral activity of Thai medicinal plants against porcine reproductive and respiratory syndrome virus

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Chaiwat Arjin ◽  
Kidsadagon Pringproa ◽  
Surat Hongsibsong ◽  
Warintorn Ruksiriwanich ◽  
Mintra Seel-audom ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antiviral Activity ◽  
Respiratory Syndrome Virus ◽  
In Vitro Screening ◽  
Thai Medicinal Plants

In Vitro Antiviral Activity of Germacrone Against Porcine Reproductive and Respiratory Syndrome Virus

2016 ◽  
Vol 73 (3) ◽  
pp. 317-323 ◽  
Author(s):  
Jiaping Feng ◽  
Xiaolei Bai ◽  
Tiantian Cui ◽  
Han Zhou ◽  
Yao Chen ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Respiratory Syndrome Virus

In vitro evaluation of antiviral activity of tea seed saponins against porcine reproductive and respiratory syndrome virus

2015 ◽  
Vol 20 (7) ◽  
pp. 743-752 ◽  
Author(s):  
E Li ◽  
Na Sun ◽  
Jun-Xing Zhao ◽  
Yao-Gui Sun ◽  
Jian-Gang Huang ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Respiratory Syndrome Virus ◽  
In Vitro Evaluation
Sign in / Sign up

Export Citation Format

Share Document