In vitro evaluation of antiviral activity of tea seed saponins against porcine reproductive and respiratory syndrome virus

2015 ◽  
Vol 20 (7) ◽  
pp. 743-752 ◽  
Author(s):  
E Li ◽  
Na Sun ◽  
Jun-Xing Zhao ◽  
Yao-Gui Sun ◽  
Jian-Gang Huang ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Respiratory Syndrome Virus ◽  
In Vitro Evaluation

In Vitro Evaluation of the Antiviral Activity of Some Mushrooms from Turkey

2018 ◽  
Vol 20 (3) ◽  
pp. 201-212 ◽  
Author(s):  
Hasan Hüseyin Doğan ◽  
Sami Karagöz ◽  
Rüstem Duman
Keyword(s):  
Antiviral Activity ◽  
In Vitro Evaluation

Tailoring acyclovir prodrugs with enhanced antiviral activity: rational design, synthesis, human plasma stability and in vitro evaluation

Amino Acids ◽  
2018 ◽  
Vol 50 (8) ◽  
pp. 1131-1143
Author(s):  
Radoslav L. Chayrov ◽  
Evgenios K. Stylos ◽  
Maria V. Chatziathanasiadou ◽  
Kiril N. Chuchkov ◽  
Aleksandra I. Tencheva ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Human Plasma ◽  
Rational Design ◽  
Plasma Stability ◽  
Design Synthesis ◽  
In Vitro Evaluation

scholarly journals In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2

2020 ◽  
Vol 181 ◽  
pp. 104878 ◽  
Author(s):  
Andrés Pizzorno ◽  
Blandine Padey ◽  
Julia Dubois ◽  
Thomas Julien ◽  
Aurélien Traversier ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
In Vitro Evaluation

In vitro antiviral activity and underlying molecular mechanisms of dipotassium glycyrrhetate against porcine reproductive and respiratory syndrome virus

2013 ◽  
Vol 18 (8) ◽  
pp. 997-1004 ◽  
Author(s):  
Zhi-Wei Wang ◽  
Na Sun ◽  
Cai-Hong Wu ◽  
Jun-Bing Jiang ◽  
Yuan-Sheng Bai ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Molecular Mechanisms ◽  
Respiratory Syndrome Virus

Preparation and in vitro evaluation of the antiviral activity of the Acyclovir complex of a β-cyclodextrin/poly(amidoamine) copolymer

2008 ◽  
Vol 126 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Marco Bencini ◽  
Elisabetta Ranucci ◽  
Paolo Ferruti ◽  
Francesco Trotta ◽  
Manuela Donalisio ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
In Vitro Evaluation

scholarly journals In Vitro Evaluation of Cyanovirin‐N Antiviral Activity, by Use of Lentiviral Vectors Pseudotyped with Filovirus Envelope Glycoproteins

2004 ◽  
Vol 189 (8) ◽  
pp. 1440-1443 ◽  
Author(s):  
Laura G. Barrientos ◽  
Fatima Lasala ◽  
Joaquin R. Otero ◽  
Anthony Sanchez ◽  
Rafael Delgado
Keyword(s):  
Antiviral Activity ◽  
Lentiviral Vectors ◽  
Envelope Glycoproteins ◽  
In Vitro Evaluation

scholarly journals Nitazoxanide and JIB-04 have broad-spectrum antiviral activity and inhibit SARS-CoV-2 replication in cell culture and coronavirus pathogenesis in a pig model

2020 ◽  
Author(s):  
Juhee Son ◽  
Shimeng Huang ◽  
Qiru Zeng ◽  
Traci L. Bricker ◽  
James Brett Case ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Body Weight Gain ◽  
Antiviral Agents ◽  
Cell Types ◽  
Respiratory Syndrome Virus ◽  
Transmissible Gastroenteritis Virus ◽  
Global Public Health ◽  
Dna And Rna

AbstractPathogenic coronaviruses represent a major threat to global public health. Here, using a recombinant reporter virus-based compound screening approach, we identified several small-molecule inhibitors that potently block the replication of the newly emerged severe acute respiratory syndrome virus 2 (SARS-CoV-2). Two compounds, nitazoxanide and JIB-04 inhibited SARS-CoV-2 replication in Vero E6 cells with an EC50 of 4.90 μM and 0.69 μM, respectively, with specificity indices of greater than 150. Both inhibitors had in vitro antiviral activity in multiple cell types against some DNA and RNA viruses, including porcine transmissible gastroenteritis virus. In an in vivo porcine model of coronavirus infection, administration of JIB-04 reduced virus infection and associated tissue pathology, which resulted in improved body weight gain and survival. These results highlight the potential utility of nitazoxanide and JIB-04 as antiviral agents against SARS-CoV-2 and other viral pathogens.

In vitro evaluation of the antiviral activity of heparan sulfate mimetic compounds against Enterovirus 71

2012 ◽  
Vol 169 (1) ◽  
pp. 22-29 ◽  
Author(s):  
Hamid Reza Pourianfar ◽  
Chit Laa Poh ◽  
John Fecondo ◽  
Lara Grollo
Keyword(s):  
Antiviral Activity ◽  
Heparan Sulfate ◽  
Enterovirus 71 ◽  
In Vitro Evaluation
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