Minocycline rinses compared to placebo and to tetracycline rinses in managing recurrent aphthous stomatitis: Double-blind cross-over studies

2006 ◽  
Vol 102 (3) ◽  
pp. 333-334
Author(s):  
Meir Gorsky ◽  
Joel Epstein ◽  
Alon Raviv ◽  
Shira Rabenstein ◽  
Noam Yarom
Keyword(s):  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Double Blind

Results of Double-Blind Placebo-Controlled Challenge with Nickel Salts in Patients Affected by Recurrent Aphthous Stomatitis

2003 ◽  
Vol 131 (4) ◽  
pp. 296-300 ◽  
Author(s):  
M.L. Pacor ◽  
G. Di Lorenzo ◽  
N. Martinelli ◽  
G. Lombardo ◽  
A. Di Gregoli ◽  
...  
Keyword(s):  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Effect of 0.5% Chitosan mouthwash on recurrent aphthous stomatitis: a randomized double-blind crossover clinical trial

10.19082/6912 ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 6912-6919 ◽  
Author(s):  
Fatemeh Rahmani ◽  
Ali Akbar Moghadamnia ◽  
Sohrab Kazemi ◽  
Atena Shirzad ◽  
Mina Motallebnejad
Keyword(s):  
Clinical Trial ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Double Blind

Effects of cooking plant oils on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial

Nutrition ◽  
2006 ◽  
Vol 22 (5) ◽  
pp. 534-538 ◽  
Author(s):  
Kei Hamazaki ◽  
Miho Itomura ◽  
Tomohito Hamazaki ◽  
Shigeki Sawazaki
Keyword(s):  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Plant Oils ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial

scholarly journals Topical NAVS naphthalan for the treatment of oral lichen planus and recurrent aphthous stomatitis: A double blind, randomized, parallel group study

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249862
Author(s):  
Ana Andabak Rogulj ◽  
Iva Z. Alajbeg ◽  
Vlaho Brailo ◽  
Ivana Škrinjar ◽  
Ivona Žužul ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Secondary Outcome ◽  
Double Blind ◽  
Link Type ◽  
Lesion Diameter ◽  
Group A ◽  
Oral Lichen

Aim To evaluate the effectiveness of non-aromatic very rich in steranes (NAVS) naphthalan in the treatment of oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS). Null hypothesis was that there would be no difference between NAVS and topical steroids in the treatment of OLP and RAS. Methods The study consisted of two sub-trials conducted as randomized, double-blind controlled studies: first included OLP patients and second patients with RAS. Patients received either NAVS or 0.05% betamethasone dipropionate. Primary outcomes were activity score (OLP patients), No of lesions and lesion diameter (RAS patients) and pain intensity (VAS) while secondary outcome included the impact of the disease on quality of life assessed by Oral health impact profile (OHIP 14). Results No significant differences in terms of OLP clinical signs (p = 0.84, η2 = 0.001) and responses on the OHIP-14 (p = 0.81, η2 = 0.002) or on VAS (p = 0.14, η2 = 0.079) between NAVS and betamethasone groups were observed. In RAS patients, no significant differences between the groups in terms of lesion number (at days 3 and 5, p = 0.33 and p = 0.98, respectively), lesion diameter (days 3 and 5, p = 0.24 and p = 0.84, respectively) were observed. However, in NAVS group a significant reduction of lesions diameter was observed on the 3rd day, while in betamethasone group a significant reduction in lesions diameter was evident only after the 5th day. No significant differences in VAS (p > 0.05) and the OHIP-14 (p > 0.05) between groups were found. Conclusion No evidence of differences between the two compared interventions was found. Registration Retrospective registration of this trial was conducted in ClinicalTrials.gov on September 30, 2016; trial registration number: NCT02920658. https://clinicaltrials.gov/ct2/show/NCT02920658?term=NAVS&draw=2&rank=4.

scholarly journals The effects of pomegranate peel extract on recurrent aphthous stomatitis

2019 ◽  
Vol 32 (3) ◽  
pp. 115-120
Author(s):  
Sara Darakhshan ◽  
Mohammad Malmir ◽  
Fereshteh Bagheri ◽  
Mohsen Safaei ◽  
Roohollah Sharifi ◽  
...  
Keyword(s):  
Folk Medicine ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Double Blind Study ◽  
Pomegranate Peel ◽  
Double Blind ◽  
Mean Values ◽  
Ulcer Size ◽  
Pomegranate Peel Extract ◽  
Peel Extract

Abstract As high as 20% of the population is thought to have recurrent aphthous stomatitis (RAS), hence, finding new therapeutic agents may be needed. Pomegranate (Punica granatum), has been extensively used in the folk medicine of many cultures, as it possesses antioxidant, anti-inflammatory and anti-bacterial properties. In this study, it is hypothesized that a topical form of pomegranate peel extract (PPE) may shorten the duration, accelerate the healing and reduce the pain of RAS patients. The presented randomized, double-blind study was conducted on 56 patients. Herein, 28 patients were advised to apply PPE gel, and the other 28 patients were given placebo gel, twice daily for one week. Efficacy evaluations were made at days 0 (before using the gel), 3, 5 and 7. The mean values of ulcer size, pain and healing duration of ulcers were compared in both groups. PPE gel was significantly effective in reducing the pain (p<0.001), ulcer size (p<0.001), and healing duration of ulcers (p<0.001) over a period of one week. PPE in the form of oral gel can be used in the management of aphthous ulcers.

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