The Temporal Dynamics of Multiple Stressor Effects: From Individuals to Ecosystems

Michelle C. Jackson; Samraat Pawar; Guy Woodward

doi:10.1016/j.tree.2021.01.005

Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.00066.2017 ◽

2017 ◽

Vol 312 (6) ◽

pp. G559-G571 ◽

Cited By ~ 93

Author(s):

J. Philip Karl ◽

Lee M. Margolis ◽

Elisabeth H. Madslien ◽

Nancy E. Murphy ◽

John W. Castellani ◽

...

Keyword(s):

Intestinal Permeability ◽

Intestinal Microbiota ◽

Relative Abundance ◽

Temporal Dynamics ◽

Physiological Stress ◽

Military Training ◽

Microbiota Composition ◽

Training Environment ◽

Markers Of Inflammation ◽

Multiple Stressor

The magnitude, temporal dynamics, and physiological effects of intestinal microbiome responses to physiological stress are poorly characterized. This study used a systems biology approach and a multiple-stressor military training environment to determine the effects of physiological stress on intestinal microbiota composition and metabolic activity, as well as intestinal permeability (IP). Soldiers ( n = 73) were provided three rations per day with or without protein- or carbohydrate-based supplements during a 4-day cross-country ski-march (STRESS). IP was measured before and during STRESS. Blood and stool samples were collected before and after STRESS to measure inflammation, stool microbiota, and stool and plasma global metabolite profiles. IP increased 62 ± 57% (mean ± SD, P < 0.001) during STRESS independent of diet group and was associated with increased inflammation. Intestinal microbiota responses were characterized by increased α-diversity and changes in the relative abundance of >50% of identified genera, including increased abundance of less dominant taxa at the expense of more dominant taxa such as Bacteroides. Changes in intestinal microbiota composition were linked to 23% of metabolites that were significantly altered in stool after STRESS. Together, pre-STRESS Actinobacteria relative abundance and changes in serum IL-6 and stool cysteine concentrations accounted for 84% of the variability in the change in IP. Findings demonstrate that a multiple-stressor military training environment induced increases in IP that were associated with alterations in markers of inflammation and with intestinal microbiota composition and metabolism. Associations between IP, the pre-STRESS microbiota, and microbiota metabolites suggest that targeting the intestinal microbiota could provide novel strategies for preserving IP during physiological stress.NEW & NOTEWORTHY Military training, a unique model for studying temporal dynamics of intestinal barrier and intestinal microbiota responses to stress, resulted in increased intestinal permeability concomitant with changes in intestinal microbiota composition and metabolism. Prestress intestinal microbiota composition and changes in fecal concentrations of metabolites linked to the microbiota were associated with increased intestinal permeability. Findings suggest that targeting the intestinal microbiota could provide novel strategies for mitigating increases in intestinal permeability during stress.

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Nonlinear Spatio-Temporal Dynamics and Chaos in Semiconductors

10.1017/cbo9780511524615 ◽

2001 ◽

Cited By ~ 136

Author(s):

Eckehard Schöll

Keyword(s):

Temporal Dynamics ◽

Spatio Temporal

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Effects of Monetary Incentives on Task Switching

Experimental Psychology (formerly Zeitschrift für Experimentelle Psychologie) ◽

10.1027/1618-3169/a000146 ◽

2012 ◽

Vol 59 (4) ◽

pp. 216-226 ◽

Cited By ~ 36

Author(s):

Thomas Kleinsorge ◽

Gerhard Rinkenauer

Keyword(s):

Task Switching ◽

Temporal Dynamics ◽

Reward Processing ◽

General Level ◽

Monetary Incentives ◽

Switch Costs ◽

Expectancy Effect ◽

Reward Expectancy ◽

Trial Basis

In two experiments, effects of incentives on task switching were investigated. Incentives were provided as a monetary bonus. In both experiments, the availability of a bonus varied on a trial-to-trial basis. The main difference between the experiments relates to the association of incentives to individual tasks. In Experiment 1, the association of incentives to individual tasks was fixed. Under these conditions, the effect of incentives was largely due to reward expectancy. Switch costs were reduced to statistical insignificance. This was true even with the task that was not associated with a bonus. In Experiment 2, there was a variable association of incentives to individual tasks. Under these conditions, the reward expectancy effect was bound to conditions with a well-established bonus-task association. In conditions in which the bonus-task association was not established in advance, enhanced performance of the bonus task was accompanied by performance decrements with the task that was not associated with a bonus. Reward expectancy affected mainly the general level of performance. The outcome of this study may also inform recently suggested neurobiological accounts about the temporal dynamics of reward processing.

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