Reasons for Low Utilization of Pancreas for Transplantation From Deceased Donors: Analysis of Data From a Single Center in India

2020 ◽  
Vol 52 (6) ◽  
pp. 1858-1859
Author(s):  
Milind Mandwar ◽  
Ashish Sharma ◽  
Sarbpreet Singh ◽  
Deepesh Benjamin Kenwar ◽  
Abhinav Seth ◽  
...  
2020 ◽  
Vol 221 (Supplement_2) ◽  
pp. S164-S173
Author(s):  
Li Tong ◽  
Xiao-Guang Hu ◽  
Fa Huang ◽  
Shun-Wei Huang ◽  
Li-Fen Li ◽  
...  

Abstract Background Information on possible donor-derived transmission events in China is limited. We evaluated the impacts of liver transplantation from infected deceased-donors, analyzed possible donor-derived bacterial or fungal infection events in recipients, and evaluated the etiologic agents’ characteristics and cases outcomes. Methods A single-center observational study was performed from January 2015 to March 2017 to retrospectively collect data from deceased-donors diagnosed with infection. Clinical data were recorded for each culture-positive donor and the matched liver recipient. The microorganisms were isolated and identified, and antibiotic sensitivity testing was performed. The pathogens distribution and incidence of possible donor-derived infection (P-DDI) events were analyzed and evaluated. Results Information from 211 donors was collected. Of these, 82 donors were infected and classified as the donation after brain death category. Overall, 149 and 138 pathogens were isolated from 82 infected donors and 82 matched liver recipients, respectively. Gram-positive bacteria, Gram-negative bacteria, and fungi accounted for 42.3% (63 of 149), 46.3% (69 of 149), and 11.4% (17 of 149) of pathogens in infected donors. The incidence of multidrug-resistant bacteria was high and Acinetobacter baumannii was the most concerning species. Infections occurred within the first 2 weeks after liver transplantation with an organ from an infected donor. Compared with the noninfection recipient group, the infection recipient group experienced a longer mechanical ventilation time (P = .004) and intensive care unit stay (P = .003), a higher incidence of renal dysfunction (P = .026) and renal replacement therapy (P = .001), and higher hospital mortality (P = .015). Possible donor-derived infection was observed in 14.6% of cases. Recipients with acute-on-chronic liver failure were more prone to have P-DDI than recipients with other diseases (P = .007; odds ratio = 0.114; 95% confidence interval, .025–.529). Conclusions When a liver recipient receives a graft from an infected deceased-donor, the postoperative incidence of infection is high and the infection interval is short. In addition, when a possible donor-derived, drug-resistant bacterial infection occurs, recipients may have serious complications and poor outcomes.


2011 ◽  
Vol 27 (1) ◽  
pp. 30 ◽  
Author(s):  
Pranjal Modi ◽  
Jamal Rizvi ◽  
Bipinchandra Pal ◽  
Hargovind Trivedi ◽  
Veena Shah ◽  
...  

2014 ◽  
Vol 98 ◽  
pp. 597
Author(s):  
A. Sharma ◽  
R. Fisher ◽  
M. Behnke ◽  
R. Ramanathan ◽  
A. King ◽  
...  

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Teresa Stock da Cunha ◽  
Raul Fernandez-Prado ◽  
Laura Castañeda-Infante ◽  
Alejandro Avello ◽  
Esmeralda Castillo-Rodríguez ◽  
...  

2011 ◽  
Vol 92 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Anja Gallinat ◽  
Thorsten Feldkamp ◽  
Randolph Schaffer ◽  
Sonia Radünz ◽  
Jürgen W. Treckmann ◽  
...  

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