Calcineurin Inhibitor-Free Immunosuppressive Strategy in Elderly Recipients of Renal Allografts From Deceased Donors: 1-Year Results From a Prospective Single Center Trial

2009 ◽  
Vol 41 (6) ◽  
pp. 2529-2532 ◽  
Author(s):  
H.P. Arbogast ◽  
J.N. Hoffmann ◽  
W.-D. Illner ◽  
G.F. Hillebrand ◽  
M. Fischereder ◽  
...  
Keyword(s):  
Calcineurin Inhibitor ◽  
Single Center ◽  
Renal Allografts ◽  
Elderly Recipients ◽  
Deceased Donors

scholarly journals Glomerular Neovascularization in Nondiabetic Renal Allograft Is Associated with Calcineurin Inhibitor Toxicity

Nephron ◽  
2020 ◽  
pp. 1-6
Author(s):  
Anri Sawada ◽  
Masayoshi Okumi ◽  
Shigeru Horita ◽  
Kohei Unagami ◽  
Sekiko Taneda ◽  
...  
Keyword(s):  
Diabetic Kidney Disease ◽  
Renal Allograft ◽  
Calcineurin Inhibitor ◽  
Clinical Information ◽  
Renal Allografts ◽  
Biopsy Specimens ◽  
Allograft Biopsy ◽  
Time Periods ◽  
Medical University ◽  
Trough Levels

<b><i>Introduction:</i></b> Extra efferent arterioles, also known as polar vasculosis (PV), are often observed in the glomerular vascular pole and are associated with glomerular hypertrophy, indicating early recurrent diabetic kidney disease (DKD) in renal allografts. However, its significance in patients without diabetes remains uncertain. <b><i>Methods:</i></b> A total of 9,004 renal allograft biopsy specimens obtained between January 2007 and December 2017 at Tokyo Women’s Medical University were retrospectively analyzed to examine the clinical and pathological significance of PV in renal allografts. PV was identified in 186 biopsy specimens obtained from 165 patients. The PV group comprised 46 patients; 35 patients without DKD and 11 patients with DKD as the initial cause of ESRD, whose clinical information was available and treated with the calcineurin inhibitor (CNI) tacrolimus. The non-PV group comprising patients with renal allografts matched for age and postoperative day included 93 patients without DKD and 16 patients with DKD as the initial cause of ESRD. <b><i>Results:</i></b> In patients with nondiabetic renal allografts, systolic blood pressure was significantly higher in the PV group than in the non-PV group. The trough tacrolimus levels during the overall study period and at 2 weeks, 1 month, and 2 years after transplantation were significantly higher in the PV group compared with the non-PV group. Glomerulomegaly was significantly more common. Moreover, ah and aah scores in Banff score were significantly higher in the PV group than in the non-PV group. In those with diabetic renal allografts, although the clinical parameters and tacrolimus trough levels in all time periods were not significantly different between the PV and non-PV groups, the ah score was significantly higher in the PV group. <b><i>Conclusion:</i></b> PV was associated with CNI toxicity in nondiabetic but not in diabetic renal allografts. The pathogenesis of PV in renal allografts is considered to be multifactorial.

Clinical Impacts and Outcomes With Possible Donor-Derived Infection in Infected Donor Liver Transplantation: A Single-Center Retrospective Study in China

2020 ◽  
Vol 221 (Supplement_2) ◽  
pp. S164-S173
Author(s):  
Li Tong ◽  
Xiao-Guang Hu ◽  
Fa Huang ◽  
Shun-Wei Huang ◽  
Li-Fen Li ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Antibiotic Sensitivity ◽  
Resistant Bacteria ◽  
Single Center ◽  
Sensitivity Testing ◽  
Donor Liver Transplantation ◽  
Infected Donor ◽  
Recipient Group ◽  
Deceased Donors ◽  
Liver Recipient

Abstract Background Information on possible donor-derived transmission events in China is limited. We evaluated the impacts of liver transplantation from infected deceased-donors, analyzed possible donor-derived bacterial or fungal infection events in recipients, and evaluated the etiologic agents’ characteristics and cases outcomes. Methods A single-center observational study was performed from January 2015 to March 2017 to retrospectively collect data from deceased-donors diagnosed with infection. Clinical data were recorded for each culture-positive donor and the matched liver recipient. The microorganisms were isolated and identified, and antibiotic sensitivity testing was performed. The pathogens distribution and incidence of possible donor-derived infection (P-DDI) events were analyzed and evaluated. Results Information from 211 donors was collected. Of these, 82 donors were infected and classified as the donation after brain death category. Overall, 149 and 138 pathogens were isolated from 82 infected donors and 82 matched liver recipients, respectively. Gram-positive bacteria, Gram-negative bacteria, and fungi accounted for 42.3% (63 of 149), 46.3% (69 of 149), and 11.4% (17 of 149) of pathogens in infected donors. The incidence of multidrug-resistant bacteria was high and Acinetobacter baumannii was the most concerning species. Infections occurred within the first 2 weeks after liver transplantation with an organ from an infected donor. Compared with the noninfection recipient group, the infection recipient group experienced a longer mechanical ventilation time (P = .004) and intensive care unit stay (P = .003), a higher incidence of renal dysfunction (P = .026) and renal replacement therapy (P = .001), and higher hospital mortality (P = .015). Possible donor-derived infection was observed in 14.6% of cases. Recipients with acute-on-chronic liver failure were more prone to have P-DDI than recipients with other diseases (P = .007; odds ratio = 0.114; 95% confidence interval, .025–.529). Conclusions When a liver recipient receives a graft from an infected deceased-donor, the postoperative incidence of infection is high and the infection interval is short. In addition, when a possible donor-derived, drug-resistant bacterial infection occurs, recipients may have serious complications and poor outcomes.

scholarly journals Dual kidney transplantation from expanded criteria deceased donors: Initial experience from single center

2011 ◽  
Vol 27 (1) ◽  
pp. 30 ◽  
Author(s):  
Pranjal Modi ◽  
Jamal Rizvi ◽  
Bipinchandra Pal ◽  
Hargovind Trivedi ◽  
Veena Shah ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Initial Experience ◽  
Single Center ◽  
Expanded Criteria ◽  
Deceased Donors

Reasons for Low Utilization of Pancreas for Transplantation From Deceased Donors: Analysis of Data From a Single Center in India

2020 ◽  
Vol 52 (6) ◽  
pp. 1858-1859
Author(s):  
Milind Mandwar ◽  
Ashish Sharma ◽  
Sarbpreet Singh ◽  
Deepesh Benjamin Kenwar ◽  
Abhinav Seth ◽  
...  
Keyword(s):  
Single Center ◽  
Deceased Donors

499 PCNL and URS in renal allografts: A single center experience with 2016 renal transplants

2012 ◽  
Vol 11 (1) ◽  
pp. e499-e499b
Author(s):  
F. Branco ◽  
V. Cavadas ◽  
L. Osorio ◽  
M. Silva-Ramos ◽  
A. Lhamas ◽  
...  
Keyword(s):  
Single Center ◽  
Renal Transplants ◽  
Renal Allografts ◽  
Single Center Experience

Excellent Outcomes After Adult Dual Kidney Transplantation From Marginal Deceased Donors: Single Center Experience.

2014 ◽  
Vol 98 ◽  
pp. 597
Author(s):  
A. Sharma ◽  
R. Fisher ◽  
M. Behnke ◽  
R. Ramanathan ◽  
A. King ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Single Center ◽  
Single Center Experience ◽  
Deceased Donors
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