scholarly journals Erythropoietin Ameliorates Lung Injury by Accelerating Pulmonary Endothelium Cell Proliferation via Janus Kinase-Signal Transducer and Activator of Transcription 3 Pathway After Kidney Ischemia and Reperfusion Injury

2019 ◽  
Vol 51 (3) ◽  
pp. 972-978 ◽  
Author(s):  
M. Zhu ◽  
L. Wang ◽  
J. Yang ◽  
K. Xie ◽  
M. Zhu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Lung Injury ◽  
Reperfusion Injury ◽  
Janus Kinase ◽  
Ischemia And Reperfusion ◽  
Signal Transducer ◽  
Ischemia And Reperfusion Injury ◽  
Pulmonary Endothelium ◽  
Transcription 3 ◽  
Kidney Ischemia

scholarly journals TLR2 and TLR4 expression after kidney ischemia and reperfusion injury in mice treated with FTY720

2011 ◽  
Vol 11 (9) ◽  
pp. 1311-1318 ◽  
Author(s):  
J.F. Pedregosa ◽  
A.A. Haidar ◽  
A.E. Hirata ◽  
M. Franco ◽  
G.N. Gomes ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia And Reperfusion ◽  
Tlr4 Expression ◽  
Ischemia And Reperfusion Injury ◽  
Kidney Ischemia

scholarly journals Kidney Ischemia and Reperfusion Injury – Field of Glory or Warterloo for Erythropoietin?

2016 ◽  
Vol 1 (3) ◽  
pp. e9-e12
Author(s):  
Florian Simon ◽  
◽  
Hubert Schelzig ◽  
Alexander Oberhuber ◽  
◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Kidney Ischemia

Ergothioneine prevents acute lung injury in mesenteric ischemia and reperfusion injury in rats

2008 ◽  
Vol 23 (2) ◽  
pp. 268-269 ◽  
Author(s):  
Ömer Sakrak ◽  
Mustafa Kerem ◽  
Abdulkadir Bedirli ◽  
Hatice Pasaoğlu ◽  
Murat Alper ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Reperfusion Injury ◽  
Mesenteric Ischemia ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury

Magnesium-dependent Phosphatase (MDP) 1 is a Potential Suppressor of Gastric Cancer

2019 ◽  
Vol 19 (10) ◽  
pp. 817-827
Author(s):  
Jianbo Zhu ◽  
Lijuan Deng ◽  
Baozhen Chen ◽  
Wenqing Huang ◽  
Xiandong Lin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Methylation ◽  
Cell Proliferation ◽  
Protein C ◽  
Biological Function ◽  
Prognostic Markers ◽  
Biological Effects ◽  
Signal Transducer ◽  
Gastric Cancer Cells ◽  
Transcription 3

Background:Recurrence is the leading cause of treatment failure and death in patients with gastric cancer (GC). However, the mechanism underlying GC recurrence remains unclear, and prognostic markers are still lacking.Methods:We analyzed DNA methylation profiles in gastric cancer cases with shorter survival (<1 year) or longer survival (> 3 years), and identified candidate genes associated with GC recurrence. Then, the biological effects of these genes on gastric cancer were studied.Results:A novel gene, magnesium-dependent phosphatase 1 (mdp1), was identified as a candidate gene whose DNA methylation was higher in GC samples from patients with shorter survival and lower in patients with longer survival. MDP1 protein was highly expressed in GC tissues with longer survival time, and also had a tendency to be expressed in highly differentiated GC samples. Forced expression of MDP1 in GC cell line BGC-823 inhibited cell proliferation, whereas the knockdown of MDP1 protein promoted cell growth. Overexpression of MDP1 in BGC-823 cells also enhanced cell senescence and apoptosis. Cytoplasmic kinase protein c-Jun N-terminal kinase (JNK) and signal transducer and activator of transcription 3 (Stat3) were found to mediate the biological function of MDP1.Conclusion:These results suggest that MDP1 protein suppresses the survival of gastric cancer cells and loss of MDP expression may benefit the recurrence of gastric cancer.

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