Structural and Functional Adaptation of the Remnant Kidney After Living Kidney Donation: Long-Term Follow-up

2017 ◽  
Vol 49 (9) ◽  
pp. 1993-1998 ◽  
Author(s):  
M. Meier ◽  
J. Winterhoff ◽  
L. Fricke ◽  
H. Lehnert ◽  
M. Nitschke
Keyword(s):  
Functional Adaptation ◽  
Kidney Donation ◽  
Living Kidney Donation ◽  
Long Term Follow Up ◽  
Remnant Kidney

scholarly journals LOng-term follow-up after liVE kidney donation (LOVE) study: a longitudinal comparison study protocol

2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Shiromani Janki ◽  
Karel W. J. Klop ◽  
Hendrikus J. A. N. Kimenai ◽  
Jacqueline van de Wetering ◽  
Willem Weimar ◽  
...  
Keyword(s):  
Study Protocol ◽  
Kidney Donation ◽  
Comparison Study ◽  
Live Kidney Donation ◽  
Long Term Follow Up ◽  
Longitudinal Comparison

scholarly journals Renal functional reserve capacity before and after living kidney donation

2018 ◽  
Vol 315 (6) ◽  
pp. F1550-F1554 ◽  
Author(s):  
Marco van Londen ◽  
Nicolien Kasper ◽  
Niek R. Hessels ◽  
A. Lianne Messchendorp ◽  
Stephan J. L. Bakker ◽  
...  
Keyword(s):  
Kidney Function ◽  
Kidney Donation ◽  
Reserve Capacity ◽  
Living Kidney Donation ◽  
Functional Reserve ◽  
Dopamine Infusion ◽  
Renal Functional Reserve ◽  
Donor Screening

Compensatory gomerular filtration rate (GFR) increase after kidney donation results in a GFR above 50% of the predonation value. The renal functional reserve (RFR) assessed by the renal response to dopamine infusion (RFRdopa) is considered to reflect functional reserve capacity and is thought to be a tool for living donor screening. However, it is unknown if the RFRdopa predicts long-term kidney function. Between 1984 and 2017, we prospectively measured GFR (125I-iothalamate) and RFR by dopamine infusion in 937 living kidney donors. We performed linear regression analysis of predonation RFRdopa and postdonation GFR. In donors with 5-yr follow-up after donation we assessed the association with long-term GFR. Mean donor age was 52  yr (SD 11); 52% were female. Mean predonation GFR was 114  ml/min (SD 22), GFRdopa was 124 ml/min (SD 24), resulting in an RFR of 9 ml/min (SD 10). Three months postdonation, GFR was 72 ml/min (SD 15) and GFRdopa was 75 ml/min (SD 15), indicating that donors still had RFRdopa [3 ml/min (SD 6), P < 0.001]. Predonation RFRdopa was not associated with predonation GFR [standardized (st.) β −0.009, P = 0.77] but was positively associated with GFR 3 mo after donation (st. β 0.12, P < 0.001). In the subgroup of donors with 5-yr follow-up data ( n = 383), RFRdopa was not associated with GFR at 5 yr postdonation (st. β 0.05, P = 0.35). In conclusion, RFRdopa is a predictor of short-term GFR after living kidney donation but not of long-term kidney function. Therefore, measurement of the RFRdopa is not a useful tool for donor screening. Studies investigating long-term renal adaptation are warranted to study the effects of living kidney donation and improve donor screening.

scholarly journals Nitric Oxide Concentration and Other Salivary Changes after Insertion of New Complete Dentures in Edentulous Subjects

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Maria de Lourdes Breseghelo ◽  
Lídia Andreu Guillo ◽  
Túlio Eduardo Nogueira ◽  
Cláudio Rodrigues Leles
Keyword(s):  
Nitric Oxide ◽  
Colorimetric Assay ◽  
The Body ◽  
Functional Adaptation ◽  
Autonomic Response ◽  
Complete Dentures ◽  
Whole Saliva ◽  
Long Term Follow Up

Objective. To assess changes in levels of salivary nitric oxide (NO) after insertion of new complete dentures and its association with clinical and salivary parameters.Methods. Nineteen fully edentulous subjects were included, mean age 64.4. Unstimulated whole saliva was collected before and after insertion of the dentures, at follow-up visits, and after 12 months. The concentration of the final stable NO product (nitrite) was measured by a colorimetric assay based on the Griess reaction. Clinical parameters were assessed during all clinical visits.Results. Functional adaptation to the dentures progressively improved, with no complaints at the long-term follow-up. NO concentration was not influenced by the level of functional adaptation, presence of injuries to the mucosa, salivary flow, and saliva viscosity. Pairwise comparison showed a reduction in NO concentration at the first follow-up compared to baseline values but differences were not statistically significant. Significant differences were observed in NO concentrations at the long-term follow-up when compared to the first (p=0.024) and second (p=0.027) visits.Conclusion. NO concentration reduced after denture insertion and returned to baseline levels in the long-term follow-up. This appears to be an autonomic response of the body and provides valuable complementary information for the management of the edentulous patient.

Long-Term Follow-Up of a Human Subject With a Remnant Kidney

1991 ◽  
Vol 18 (4) ◽  
pp. 509-513 ◽  
Author(s):  
Edwin A. Rutsky ◽  
Eva V. Dubovsky ◽  
Katharine A. Kirk
Keyword(s):  
Human Subject ◽  
Long Term Follow Up ◽  
Remnant Kidney

Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

2019 ◽  
Vol 42 ◽  
Author(s):  
John P. A. Ioannidis
Keyword(s):  
Mental Health ◽  
Mental Disease ◽  
Brain Disorders ◽  
Social Stressors ◽  
Labor Education ◽  
Mental Diseases ◽  
Long Term Follow Up ◽  
Political Decisions

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

A comparison of two approaches to biofeedback treatment in children with recalcitrant constipation/encopresis. Long term follow up

2001 ◽  
Vol 120 (5) ◽  
pp. A397-A397
Author(s):  
M SAMERAMMAR ◽  
J CROFFIE ◽  
M PFEFFERKORN ◽  
S GUPTA ◽  
M CORKINS ◽  
...  
Keyword(s):  
Long Term Follow Up ◽  
Biofeedback Treatment

Endoscopic sphiecterotomy without cholecystectomy for prevention of recurrence of acute billary pancreatitis: Long-term follow-up of 73 patients

2001 ◽  
Vol 120 (5) ◽  
pp. A204-A204
Author(s):  
B GONZALEZCONDE ◽  
J VAZQUEZIGLESIAS ◽  
L LOPEZROSES ◽  
P ALONSOAGUIRRE ◽  
A LANCHO ◽  
...  
Keyword(s):  
Long Term Follow Up ◽  
Prevention Of Recurrence
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