Effect of Cytomegalovirus Infection on Survival of Older Kidney Transplant Patients (D+/R+): Impact of Valganciclovir Prophylaxis Versus Preemptive Therapy

2016 ◽  
Vol 48 (9) ◽  
pp. 2931-2937 ◽  
Author(s):  
E. Luna ◽  
F. Caravaca ◽  
F. Ferreira ◽  
N. Fernandez ◽  
P. Martín ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Cytomegalovirus Infection ◽  
Preemptive Therapy ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals Is HERV-K and HERV-W Expression Regulated by miR-155 in Kidney Transplant Patients with Human Cytomegalovirus Infection?

Intervirology ◽  
2018 ◽  
Vol 61 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Massimiliano Bergallo ◽  
Valentina Daprà ◽  
Cristina Calvi ◽  
Paola Montanari ◽  
Ilaria Galliano ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Human Cytomegalovirus ◽  
Cytomegalovirus Infection ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Human Cytomegalovirus Infection

CD56+ T cells are increased in kidney transplant patients following cytomegalovirus infection

2015 ◽  
Vol 17 (4) ◽  
pp. 518-526 ◽  
Author(s):  
M. Almehmadi ◽  
A. Hammad ◽  
S. Heyworth ◽  
J. Moberly ◽  
D. Middleton ◽  
...  
Keyword(s):  
T Cells ◽  
Kidney Transplant ◽  
Cytomegalovirus Infection ◽  
Transplant Patients ◽  
Kidney Transplant Patients

Individualization of Valganciclovir Prophylaxis for Cytomegalovirus Infection in Pediatric Kidney Transplant Patients

2012 ◽  
Vol 34 (3) ◽  
pp. 326-330 ◽  
Author(s):  
Wei Zhao ◽  
May Fakhoury ◽  
Marc Fila ◽  
Véronique Baudouin ◽  
Georges Deschênes ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Cytomegalovirus Infection ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals Diagnosis of Cytomegalovirus Infection by the Detection of Early Antigen (pp65) in Leukocytes of Kidney Transplant Patients

1999 ◽  
Vol 8 (2) ◽  
pp. 85-90 ◽  
Author(s):  
A.S. Pacsa ◽  
A. El-Shazly ◽  
R.K. Gupta ◽  
K.V. Johny ◽  
M.R.N. Nampoory ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Cytomegalovirus Infection ◽  
Early Antigen ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals Clinical validation of an in-house quantitative real time PCR assay for cytomegalovirus infection using the 1st WHO International Standard in kidney transplant patients

2021 ◽  
Author(s):  
Cassia F.B. Caurio ◽  
Odelta S. Allende ◽  
Roger Kist ◽  
Kênya L. Santos ◽  
Izadora C.S. Vasconcellos ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Roc Curve ◽  
Curve Analysis ◽  
Preemptive Therapy ◽  
Solid Organ ◽  
Clinical Validation ◽  
Roc Curve Analysis ◽  
Transplant Patients ◽  
Two Samples ◽  
Kidney Transplant Patients

Abstract Introduction: Cytomegalovirus (CMV) is one of the most common agents of infection in solid organ transplant patients, with significant morbidity and mortality. Objective: This study aimed to establish a threshold for initiation of preemptive treatment. In addition, the study compared the performance of antigenemia with qPCR results. Study design: This was a prospective cohort study conducted in 2017 in a single kidney transplant center in Brazil. Clinical validation was performed by comparing in-house qPCR results, against standard of care at that time (Pp65 CMV Antigenemia). ROC curve analysis was performed to determine the ideal threshold for initiation of preemptive therapy based on the qPCR test results. Results: Two hundred and thirty two samples from 30 patients were tested with both antigenemia and qPCR, from which 163 (70.26%) were concordant (Kappa coefficient: 0.435, p<0.001; Spearman correlation: 0.663). PCR allowed for early diagnoses. The median number of days for the first positive result was 50 (range, 24-105) for antigenemia and 42 (range, 24-74) for qPCR (p<0.001). ROC curve analysis revealed that at a threshold of 3,430 IU/mL (Log 3.54), qPCR had a sensitivity of 97.06% and a specificity of 74.24% (AUC 0.92617 ± 0.0185, p<0.001), in the prediction of 10 cells/105 leukocytes by antigenemia and physician's decision to treat. Conclusions: CMV Pp65 antigenemia and CMV qPCR showed fair agreement and a moderate correlation in this study. The in-house qPCR was revealed to be an accurate method to determine CMV DNAemia in kidney transplant patients, resulting in positive results weeks before antigenemia.

Detection of Specific IgA Antibodies in Serum of Kidney Transplant Patients with Recurrent Cytomegalovirus Infection

Intervirology ◽  
1981 ◽  
Vol 15 (4) ◽  
pp. 228-234 ◽  
Author(s):  
I. Sarov ◽  
M. Siqueira-Linhares ◽  
Y. Chardonnet ◽  
E. Levy ◽  
M. Aymard ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Cytomegalovirus Infection ◽  
Transplant Patients ◽  
Iga Antibodies ◽  
Kidney Transplant Patients

mir-155 expression is downregulated in kidney transplant patients with human cytomegalovirus infection

2017 ◽  
Vol 43-44 ◽  
pp. 60-63
Author(s):  
Massimiliano Bergallo ◽  
Stefano Gambarino ◽  
Paola Montanari ◽  
Valentina Daprà ◽  
Marco Rassu ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Human Cytomegalovirus ◽  
Cytomegalovirus Infection ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Human Cytomegalovirus Infection
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