CD56+ T cells are increased in kidney transplant patients following cytomegalovirus infection

2015 ◽  
Vol 17 (4) ◽  
pp. 518-526 ◽  
Author(s):  
M. Almehmadi ◽  
A. Hammad ◽  
S. Heyworth ◽  
J. Moberly ◽  
D. Middleton ◽  
...  
Keyword(s):  
T Cells ◽  
Kidney Transplant ◽  
Cytomegalovirus Infection ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals Is HERV-K and HERV-W Expression Regulated by miR-155 in Kidney Transplant Patients with Human Cytomegalovirus Infection?

Intervirology ◽  
2018 ◽  
Vol 61 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Massimiliano Bergallo ◽  
Valentina Daprà ◽  
Cristina Calvi ◽  
Paola Montanari ◽  
Ilaria Galliano ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Human Cytomegalovirus ◽  
Cytomegalovirus Infection ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Human Cytomegalovirus Infection

scholarly journals CD45RC Expression of Circulating CD8+ T Cells Predicts Acute Allograft Rejection: A Cohort Study of 128 Kidney Transplant Patients

2019 ◽  
Vol 8 (8) ◽  
pp. 1147 ◽  
Author(s):  
Lemerle ◽  
Garnier ◽  
Planchais ◽  
Brilland ◽  
Subra ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Kidney Transplant ◽  
Cd8 T Cells ◽  
De Novo ◽  
Predictive Biomarkers ◽  
Transplant Patients ◽  
History Of ◽  
Kidney Transplant Patients ◽  
A Prospective Study

Predictive biomarkers of acute rejection (AR) are lacking. Pre-transplant expression of CD45RC on blood CD8+ T cells has been shown to predict AR in kidney transplant (KT) patients. The objective of the present study was to study CD45RC expression in a large cohort of KT recipients exposed to modern immunosuppressive regimens. CD45RC expression on T cells was analyzed in 128 KT patients, where 31 patients developed AR, of which 24 were found to be T-cell mediated (TCMR). Pre-transplant CD4+ and CD8+ CR45RChigh T cell proportions were significantly higher in patients with AR. The frequency of CD45RChigh T cells was significantly associated with age at transplantation but was not significantly different according to gender, history of transplantation, pre-transplant immunization, and de novo donor specific anti-Human Leucocyte Antigen (HLA) antibody. Survival-free AR was significantly better in patients with CD8+ CD45RChigh T cells below 58.4% (p = 0.0005), but not different according to CD4+ T cells (p = 0.073). According to multivariate analysis, CD8+ CD45RChigh T cells above 58.4% increased the risk of AR 4-fold (HR 3.96, p = 0.003). Thus, pre-transplant CD45RC expression on CD8+ T cells predicted AR, mainly TCMR, in KT patients under modern immunosuppressive therapies. We suggest that CD45RC expression should be evaluated in a prospective study to validate its usefulness to quantify the pre-transplant risk of AR.

scholarly journals Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients

2015 ◽  
Vol 7 (272) ◽  
pp. 272ra10-272ra10 ◽  
Author(s):  
Heather Morris ◽  
Susan DeWolf ◽  
Harlan Robins ◽  
Ben Sprangers ◽  
Samuel A. LoCascio ◽  
...  
Keyword(s):  
T Cells ◽  
Kidney Transplant ◽  
Clonal Deletion ◽  
Transplant Patients ◽  
Kidney Transplant Patients

Functional analysis of CD4+ CD25bright T cells in kidney transplant patients: improving suppression of donor-directed responses after transplantation

2008 ◽  
Vol 22 (5) ◽  
pp. 579-586 ◽  
Author(s):  
Varsha D.K.D. Sewgobind ◽  
Luc J.W. Van Der Laan ◽  
Mariska Klepper ◽  
Jan N.M. IJzermans ◽  
Huug W. Tilanus ◽  
...  
Keyword(s):  
Functional Analysis ◽  
T Cells ◽  
Kidney Transplant ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals Differentially methylated regions in T cells identify kidney transplant patients at risk for de novo skin cancer

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Fleur S. Peters ◽  
Annemiek M. A. Peeters ◽  
Pooja R. Mandaviya ◽  
Joyce B. J. van Meurs ◽  
Leo J. Hofland ◽  
...  
Keyword(s):  
At Risk ◽  
T Cells ◽  
Skin Cancer ◽  
Kidney Transplant ◽  
De Novo ◽  
Differentially Methylated Regions ◽  
Transplant Patients ◽  
Patients At Risk ◽  
Kidney Transplant Patients

Identification of Kidney Transplant Patients at Risk for Skin Cancer by Differentially Methylated Regions in T Cells

2017 ◽  
Vol 101 ◽  
pp. S42
Author(s):  
Fleur Peters ◽  
Annemiek MA Peeters ◽  
Pooja R. Mandaviya ◽  
Jacqueline van de Wetering ◽  
Michiel GH Betjes ◽  
...  
Keyword(s):  
At Risk ◽  
T Cells ◽  
Skin Cancer ◽  
Kidney Transplant ◽  
Differentially Methylated Regions ◽  
Transplant Patients ◽  
Patients At Risk ◽  
Kidney Transplant Patients

Characterization of CD28−CD4+ T cells in living kidney transplant patients with long-term allograft acceptance

2001 ◽  
Vol 62 (12) ◽  
pp. 1335-1345 ◽  
Author(s):  
Masashi Kato ◽  
Tetsuya Matsuguchi ◽  
Yoshinari Ono ◽  
Ryohei Hattori ◽  
Shinichi Ohshima ◽  
...  
Keyword(s):  
T Cells ◽  
Kidney Transplant ◽  
Cd4 T Cells ◽  
Transplant Patients ◽  
Kidney Transplant Patients
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