Variability of Mycophenolate Mofetil Trough Levels in Stable Kidney Transplant Patients

2007 ◽  
Vol 39 (7) ◽  
pp. 2185-2186 ◽  
Author(s):  
A. Fernández ◽  
J. Martins ◽  
J.J. Villlafruela ◽  
R. Marcén ◽  
J. Pascual ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Kidney Transplant ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Trough Levels

scholarly journals Immune Response after SARS-CoV-2 Vaccination in Kidney Transplant Patients

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1327
Author(s):  
Ruta Vaiciuniene ◽  
Brigita Sitkauskiene ◽  
Inga Arune Bumblyte ◽  
Egle Dalinkeviciene ◽  
Edita Ziginskiene ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Antibody Response ◽  
Kidney Transplant ◽  
Kidney Function ◽  
Hemoglobin Level ◽  
Total Leucocyte Count ◽  
Binary Logistic Regression Analysis ◽  
Cd8 Cells ◽  
Transplant Patients ◽  
Kidney Transplant Patients

Background and Objectives: The prospective study was conducted to evaluate humoral and cellular immune responses after two doses of BNT162b2 (Pfizer-BioNTech) vaccine and possible relation with other factors (medication, etc.) in kidney transplant patients. Materials and Methods: Out of 167 vaccinated patients, 136 agreed to a follow-up visit three to six weeks after vaccination. Results: Only 39 patients (29%) developed antibody response against SARS-CoV-2 (≥35.2 binding antibody units (BAU)/mL) after full vaccination. Multivariate binary logistic regression analysis showed that predictive factors for good antibody response to the COVID-19 vaccine were better kidney function, higher hemoglobin level, and no use of mycophenolate mofetil for immunosuppression. For seropositive kidney transplant patients there was a significant negative correlation between anti-SARS-CoV-2 antibody titer and CD4/CD8 ratio (Spearman’s correlation coefficient −0.4, p = 0.02), percentage of CD19+ cells (r = −0.37, p = 0.02), and a positive correlation with percentage of CD8+ cells (r = 0.4, p = 0.01). There was an increase of total leucocyte count after vaccination in the total studied population, and in the group of responders. Conclusions: Only one third of kidney transplant patients develop sufficient antibody responses after full COVID-19 vaccination with Pfizer-BioNTech. Better kidney function, higher hemoglobin level, and no use of mycophenolate mofetil for immunosuppression increases the adequacy of response. The antibody titers correlated positively with relative number of CD8+ cells and negatively with CD4/CD8 ratio in responders.

Coadministration of Tacrolimus and Mycophenolate Mofetil in Stable Kidney Transplant Patients: Pharmacokinetics and Tolerability

2000 ◽  
Vol 40 (5) ◽  
pp. 527-532 ◽  
Author(s):  
John Pirsch ◽  
Ihor Bekersky ◽  
Flavio Vincenti ◽  
Garry Boswell ◽  
E. Steve Woodle ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Kidney Transplant ◽  
Transplant Patients ◽  
Kidney Transplant Patients

Pharmacokinetics of Mycophenolate Mofetil in Kidney Transplant Patients With Renal Insufficiency

2005 ◽  
Vol 37 (9) ◽  
pp. 3749-3751 ◽  
Author(s):  
F.M. González-Roncero ◽  
M.A. Gentil ◽  
M. Brunet ◽  
G. Algarra ◽  
P. Pereira ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Renal Insufficiency ◽  
Kidney Transplant ◽  
Transplant Patients ◽  
Kidney Transplant Patients

PHARMACOKINETIC BASIS OF EFFICIENT AND SAFE USE OF LOW MYCOPHENOLATE MOFETIL (MMF,1g/DAY) IN COMBINATION WITH TACROLIMUS IN KIDNEY TRANSPLANT PATIENTS.

2000 ◽  
Vol 69 (Supplement) ◽  
pp. S161
Author(s):  
Michel L. Mourad ◽  
Jacques Malaise ◽  
Djamila Chaib-Eddour ◽  
Raf Scheppers ◽  
Josianne De Koenig ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Kidney Transplant ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals Influence of everolimus on mycophenolate mofetil pharmacokinetics in kidney transplant patients

2020 ◽  
Vol 34 (1) ◽  
pp. S89-S89
Author(s):  
Takahito Endo ◽  
Takuya Fujimoto ◽  
Shun Nishioka ◽  
Naoki Yokoyama ◽  
Satoshi Ogawa ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Kidney Transplant ◽  
Transplant Patients ◽  
Kidney Transplant Patients
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