Pharmacokinetics of Mycophenolate Mofetil in Kidney Transplant Patients With Renal Insufficiency

2005 ◽  
Vol 37 (9) ◽  
pp. 3749-3751 ◽  
Author(s):  
F.M. González-Roncero ◽  
M.A. Gentil ◽  
M. Brunet ◽  
G. Algarra ◽  
P. Pereira ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Renal Insufficiency ◽  
Kidney Transplant ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals Immune Response after SARS-CoV-2 Vaccination in Kidney Transplant Patients

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1327
Author(s):  
Ruta Vaiciuniene ◽  
Brigita Sitkauskiene ◽  
Inga Arune Bumblyte ◽  
Egle Dalinkeviciene ◽  
Edita Ziginskiene ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Antibody Response ◽  
Kidney Transplant ◽  
Kidney Function ◽  
Hemoglobin Level ◽  
Total Leucocyte Count ◽  
Binary Logistic Regression Analysis ◽  
Cd8 Cells ◽  
Transplant Patients ◽  
Kidney Transplant Patients

Background and Objectives: The prospective study was conducted to evaluate humoral and cellular immune responses after two doses of BNT162b2 (Pfizer-BioNTech) vaccine and possible relation with other factors (medication, etc.) in kidney transplant patients. Materials and Methods: Out of 167 vaccinated patients, 136 agreed to a follow-up visit three to six weeks after vaccination. Results: Only 39 patients (29%) developed antibody response against SARS-CoV-2 (≥35.2 binding antibody units (BAU)/mL) after full vaccination. Multivariate binary logistic regression analysis showed that predictive factors for good antibody response to the COVID-19 vaccine were better kidney function, higher hemoglobin level, and no use of mycophenolate mofetil for immunosuppression. For seropositive kidney transplant patients there was a significant negative correlation between anti-SARS-CoV-2 antibody titer and CD4/CD8 ratio (Spearman’s correlation coefficient −0.4, p = 0.02), percentage of CD19+ cells (r = −0.37, p = 0.02), and a positive correlation with percentage of CD8+ cells (r = 0.4, p = 0.01). There was an increase of total leucocyte count after vaccination in the total studied population, and in the group of responders. Conclusions: Only one third of kidney transplant patients develop sufficient antibody responses after full COVID-19 vaccination with Pfizer-BioNTech. Better kidney function, higher hemoglobin level, and no use of mycophenolate mofetil for immunosuppression increases the adequacy of response. The antibody titers correlated positively with relative number of CD8+ cells and negatively with CD4/CD8 ratio in responders.

Variability of Mycophenolate Mofetil Trough Levels in Stable Kidney Transplant Patients

2007 ◽  
Vol 39 (7) ◽  
pp. 2185-2186 ◽  
Author(s):  
A. Fernández ◽  
J. Martins ◽  
J.J. Villlafruela ◽  
R. Marcén ◽  
J. Pascual ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Kidney Transplant ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Trough Levels

Coadministration of Tacrolimus and Mycophenolate Mofetil in Stable Kidney Transplant Patients: Pharmacokinetics and Tolerability

2000 ◽  
Vol 40 (5) ◽  
pp. 527-532 ◽  
Author(s):  
John Pirsch ◽  
Ihor Bekersky ◽  
Flavio Vincenti ◽  
Garry Boswell ◽  
E. Steve Woodle ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Kidney Transplant ◽  
Transplant Patients ◽  
Kidney Transplant Patients

PHARMACOKINETIC BASIS OF EFFICIENT AND SAFE USE OF LOW MYCOPHENOLATE MOFETIL (MMF,1g/DAY) IN COMBINATION WITH TACROLIMUS IN KIDNEY TRANSPLANT PATIENTS.

2000 ◽  
Vol 69 (Supplement) ◽  
pp. S161
Author(s):  
Michel L. Mourad ◽  
Jacques Malaise ◽  
Djamila Chaib-Eddour ◽  
Raf Scheppers ◽  
Josianne De Koenig ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Kidney Transplant ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals Influence of everolimus on mycophenolate mofetil pharmacokinetics in kidney transplant patients

2020 ◽  
Vol 34 (1) ◽  
pp. S89-S89
Author(s):  
Takahito Endo ◽  
Takuya Fujimoto ◽  
Shun Nishioka ◽  
Naoki Yokoyama ◽  
Satoshi Ogawa ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Kidney Transplant ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals SIDE EFFECTS OF CYCLOSPORINE COMPARED TO TACROLIMUS AMONG YEMENI KIDNEY TRANSPLANT PATIENTS WHO SHARE THE SAME ADJUVANT AGENTS: MYCOPHENOLATE MOFETIL AND PREDNISONE

2020 ◽  
Author(s):  
Ibtesam Abdullah Al-Akwa’a ◽  
Nagieb Waza'a Abu Asba ◽  
Khaled Abdl Karim Al-Moyed ◽  
Hassan Abdul Wahab Al-Shamahy ◽  
Ahmed M. Al-Haddad
Keyword(s):  
Mycophenolate Mofetil ◽  
Side Effects ◽  
Peer Review ◽  
Kidney Transplant ◽  
Lipid Profiles ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Tract Infections ◽  
Glutamyl Transferase ◽  
Kidney Functions

Background: A renal allograft is the optimum therapeutic option for patients with end stage renal diseases. Nevertheless, rejection still represents a large challenge. So as to overcome this matter, treatment strategies comprise the combined use of anti-inflammatory  and immunosuppressive agents, although they are not free from complications . Interestingly, the major cause of morbidity and mortality after the first transplanted year are due to disorders unrelated directly to immunologic etiology or disease related to immunosuppressive drugs. Objectives: The purpose of this study is to determine the side effects in renal transplant Yemeni patients adherence to cyclosporine compared to tacrolimus sharing the same adjuvant agents which are mycophenolate mofetil "MMF" and prednisone. Subject and methods: This prospective study was carried on 100 kidney transplanted Yemeni patients divided into two groups: cyclosporine group (n=50) and tacrolimus group (n=50), each member of these groups was visited three times, blood samples were collected for biochemical functions including fasting blood sugar, liver enzymes, kidney functions, lipid profiles and white blood cells counts and results were obtained from the tests performed. Body weight and blood pressure had been examined; clinical complications were also recorded. Results: This study showed that serum total and direct bilirubine, gamma glutamyl transferase "GGT" and lipid profiles were elevated in cyclosporine group, whereas in tacrolimus group they were within normal range. The incidence of complicated events reported as follows: Hairtusim, gum hyperplasia, herpeszoster, CUSHING face and obesity were obviously present in cyclosporine group, while in tacrolimus group diabetes mellitus, hair loss and gastrointestinal tract infections were in existence. Conclusion: This study found that a tacrolimus-based treatment was significantly better than an immunosuppressive regimen based on cyclosporine due to the generally less side effects associated with tacrolimus, despite its effect on increasing diabetes among kidney transplant patients. Peer Review History: Received: 18 September 2020; Revised: 5 October; Accepted: 16 October, Available online: 15 November 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, [email protected] Dr. Mohamed Awad AbdAlaziz Mousnad, International University of Africa (IUA) and Sudan, [email protected] Maged Almezgagi, The Key Laboratory of high-altitude medical application of Qinghai Province, Qinghai Xining 810001, China. [email protected] Ali Awad Allah Ali Moh. Saeed, National University, Sudan, [email protected] Comments of reviewer(s): Similar Articles: LEVEL OF LEAD IN THE BLOOD AMONG FUEL STATION EMPLOYEES AND ITS RELATIONSHIP TO IMPAIRED LIVER AND KIDNEY FUNCTIONS IN DAMASCUS; SYRIA: OCCUPATIONAL EXPOSURE TO LEAD BACTERIAL CONTAMINATION OF DIALYSIS WATER AND DIALYSATE AT MUKALLA ARTIFICIAL KIDNEY CENTER IN MUKALLA CITY - HADHRAMAUT - YEMEN: RATE OF CONTAMINATION AND SENSITIVITY OF BACTERIAL ISOLATES TO ANTIBIOTICS

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