Disseminated Scedosporium Apiospermum Infection in Renal Transplant Recipient: Long-Term Successful Treatment With Voriconazole: A Case Report

2007 ◽  
Vol 39 (6) ◽  
pp. 2033-2035 ◽  
Author(s):  
P.G. Rogasi ◽  
M. Zanazzi ◽  
J. Nocentini ◽  
E. Fantoni ◽  
M. Trotta ◽  
...  
Keyword(s):  
Case Report ◽  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Successful Treatment ◽  
Scedosporium Apiospermum

Severe Scedosporium apiospermum Infection in a Recent Renal Transplant Recipient: Case Report

2018 ◽  
Vol 50 (2) ◽  
pp. 683-684
Author(s):  
M.J. Torres-Sánchez ◽  
E. Hernández-García ◽  
J. Gómez-Sánchez ◽  
M. Palomares-Bayo ◽  
M. Peña-Ortega ◽  
...  
Keyword(s):  
Case Report ◽  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Scedosporium Apiospermum

scholarly journals Case Report: Management of a Multidrug-Resistant CMV-Strain in a Renal Transplant Recipient by High-Dose CMV-Specific Immunoglobulins, Modulation in Immunosuppression, and Induction of CMV-Specific Cellular Immunity

2021 ◽  
Vol 11 ◽  
Author(s):  
Vanessa Wiening ◽  
Tina Schmidt ◽  
Maximilian Dahmen ◽  
Sami Siam ◽  
Stefan Reuter ◽  
...  
Keyword(s):  
Case Report ◽  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Successful Treatment ◽  
Cyclosporine A ◽  
Antiviral Treatment ◽  
Multidrug Resistant ◽  
High Dose ◽  
Solid Organ

The management of multidrug-resistant strains of cytomegalovirus after solid organ transplantation is challenging. This case report demonstrates the successful treatment of a multidrug-resistant strain of cytomegalovirus that may represent a valuable option for problematic cases. This report illustrates the emergence of a multidrug-resistant cytomegalovirus (CMV) UL54 mutant strain in a renal transplant recipient with severe lymphopenia and thrombocytopenia. We show that the combined treatment with high-dose intravenous cytomegalovirus-specific immunoglobulins (CMV-IVIG) after the switch to a mammalian target of rapamycin (mTOR)-inhibitor and cyclosporine A was a successful treatment alternative to direct antiviral treatment with high-dose ganciclovir and foscarnet. This treatment was associated with a quantitative induction of CMV-specific CD4 and CD8 T cells that showed maturation in phenotype and functionality with decreasing viral load. Our case report illustrates that high-dose CMV-IVIG and conversion of immunosuppressive drugs to mTOR inhibitors and cyclosporine A can be a successful treatment in a situation where the use of direct antiviral drugs was considered insufficient.

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