The Suppressive Effect of Resveratrol on Protein Kinase Cθ in Peripheral Blood T Lymphocytes in a Rat Liver Transplantation Model

2006 ◽  
Vol 38 (9) ◽  
pp. 3052-3054 ◽  
Author(s):  
S.-L. Wu ◽  
L. Yu ◽  
X.-Y. Jiao ◽  
K.-W. Meng ◽  
C.-E. Pan
Keyword(s):  
Liver Transplantation ◽  
Protein Kinase ◽  
T Lymphocytes ◽  
Rat Liver ◽  
Peripheral Blood ◽  
Suppressive Effect ◽  
Rat Liver Transplantation ◽  
Transplantation Model

The Role of Tacrolimus Nanomicelles in Acute Rejection After Liver Transplantation in Rats

2021 ◽  
Vol 21 (2) ◽  
pp. 1061-1069
Author(s):  
Zhantao Xie ◽  
Huibo Zhao ◽  
Yuan Chen ◽  
Sidong Wei ◽  
Jianjun Sun ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Transplantation ◽  
Animal Model ◽  
Acute Rejection ◽  
Rat Liver ◽  
Brown Norway ◽  
Rat Liver Transplantation ◽  
Transplantation Model

Although there is some progress in immunosuppressive therapy of acute rejection, there is still a lack of standardized diagnosis and treatment. For the acute rejection after liver transplantation, there is still a lack of an exact treatment at this stage. Tacrolimus (TAC) side effects will also affect the survival rate and quality of life of recipients after transplantation to a large extent. Rat orthotopic liver transplantation model was established and divided into three groups. In the tolerance group, Brown Norway (BN) to Lewis liver transplantation was used; in the rejection group, Lewis to BN liver transplantation was used; in the TAC group, TAC was injected after operation on the basis of establishing rejection model. The expression of GITRL in Kupffer cells and the change of cytokines were detected 7 days after operation. In this study, the animal model of acute rejection of rat liver transplantation was established to simulate the clinical allogeneic liver transplantation, and the important role of TAC in the acute rejection of rat liver transplantation was evaluated.

scholarly journals Increased expression of Notch 1 in a rat liver transplantation model

2015 ◽  
Vol 12 (4) ◽  
pp. 5293-5297
Author(s):  
LIHONG CHEN ◽  
WUBING HE ◽  
KAIDA HUANG ◽  
LIN ZHENG ◽  
LINGYUN GAO ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Rat Liver ◽  
Notch 1 ◽  
Rat Liver Transplantation ◽  
Transplantation Model
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