Evaluation of Type 1 Diabetics for Simultaneous Pancreas-Kidney Transplantation With Regard to Cardiovascular Risk

2006 ◽  
Vol 38 (3) ◽  
pp. 747-750 ◽  
Author(s):  
G. Woeste ◽  
C. Wullstein ◽  
C. Zapletal ◽  
I.A. Hauser ◽  
J. Gossmann ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Cardiovascular Risk ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation

Type 1 Diabetes Recurrence After Simultaneous Pancreas-Kidney Transplantation

2018 ◽  
Vol 5 (4) ◽  
pp. 295-303
Author(s):  
George W. Burke ◽  
Gaetano Ciancio ◽  
Mahmoud Morsi ◽  
Jose Figueiro ◽  
Linda Chen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Kidney Transplantation ◽  
Diabetes Recurrence ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation

scholarly journals Beneficial Effect of Successful Simultaneous Pancreas-Kidney Transplantation on Plasma Profile of Metalloproteinases in Type 1 Diabetes Mellitus Patients

2021 ◽  
Vol 10 (17) ◽  
pp. 3800
Author(s):  
Jerzy Chudek ◽  
Aureliusz Kolonko ◽  
Jacek Ziaja ◽  
Tomasz Francuz ◽  
Dorota Kamińska ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Glucose Metabolism ◽  
Matrix Metalloproteinases ◽  
Intima Media Thickness ◽  
Post Transplantation ◽  
Normal Glucose ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation

It is not fully elucidated whether the restoring of normal glucose metabolism after successful simultaneous pancreas-kidney transplantation (SPK) improves vascular wall morphology and function in type 1 diabetic (T1D) patients. Therefore, we compared arterial stiffness, assessed by pulse wave velocity (PWV), carotid intima-media thickness (IMT), and biomarkers of arterial wall calcification in T1D patients after SPK or kidney transplantation alone (KTA). In 39 SPK and 39 KTA adult patients of similar age, PWV, IMT, circulating matrix metalloproteinases (MMPs) and calcification biomarkers were assessed at median 83 months post transplantation. Additionally, carotid plaques were visualized and semi-qualitatively classified. Although PWV and IMT values were similar, the occurrence of atherosclerotic plaques (51.3 vs. 70.3%, p < 0.01) and calcified lesions (35.9 vs. 64.9%, p < 0.05) was lower in SPK patients. There were significantly lower concentrations of MMP-1, MMP-2, MMP-3, and osteocalcin in SPK subjects. Among the analyzed biomarkers, only logMMP-1, logMMP-2, and logMMP-3 concentrations were associated with log HbA1c. Multivariate stepwise backward regression analysis revealed that MMP-1 and MMP-3 variability were explained only by log HbA1c. Normal glucose metabolism achieved by SPK is followed by the favorable profile of circulating matrix metalloproteinases, which may reflect the vasoprotective effect of pancreas transplantation.

Elevated MBL levels in type 1 diabetic patients are reversed after simultaneous pancreas–kidney transplantation

2014 ◽  
Vol 31 (4) ◽  
pp. 226
Author(s):  
Pieter van der Pol ◽  
Danielle J. van Gijlswijk-Jansen ◽  
Roel Bijkerk ◽  
Eelco J.P. de Koning ◽  
Johan W. de Fijter ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Diabetic Patients ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Type 1 Diabetic Patients ◽  
Simultaneous Pancreas Kidney Transplantation
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