scholarly journals Microvascular Damage in Type 1 Diabetic Patients Is Reversed in the First Year After Simultaneous Pancreas-Kidney Transplantation

2013 ◽  
Vol 13 (5) ◽  
pp. 1272-1281 ◽  
Author(s):  
M. Khairoun ◽  
E. J. P. de Koning ◽  
B. M. van den Berg ◽  
E. Lievers ◽  
H.C. de Boer ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
First Year ◽  
Diabetic Patients ◽  
Microvascular Damage ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Type 1 Diabetic Patients ◽  
Simultaneous Pancreas Kidney Transplantation

Elevated MBL levels in type 1 diabetic patients are reversed after simultaneous pancreas–kidney transplantation

2014 ◽  
Vol 31 (4) ◽  
pp. 226
Author(s):  
Pieter van der Pol ◽  
Danielle J. van Gijlswijk-Jansen ◽  
Roel Bijkerk ◽  
Eelco J.P. de Koning ◽  
Johan W. de Fijter ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Diabetic Patients ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Type 1 Diabetic Patients ◽  
Simultaneous Pancreas Kidney Transplantation

scholarly journals A Valine Mismatch at Position 129 of MICA Is an Independent Predictor of Cytomegalovirus Infection and Acute Kidney Rejection in Simultaneous Pancreas–Kidney Transplantation Recipients

2018 ◽  
Vol 19 (9) ◽  
pp. 2618 ◽  
Author(s):  
Rafael Michita ◽  
José Chies ◽  
Sabine Schramm ◽  
Peter Horn ◽  
Falko Heinemann ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Natural Killer ◽  
Cytomegalovirus Infection ◽  
Independent Predictor ◽  
Soluble Form ◽  
First Year ◽  
Post Transplantation ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation

The polymorphic major histocompatibility complex class I chain-related molecule A (MICA) and its soluble form (sMICA) interact with activating receptor natural-killer group 2 member D (NKG2D) on natural-killer (NK) and T cells, thereby modifying immune responses to transplantation and infectious agents (e.g., cytomegalovirus). Two single-nucleotide polymorphisms (SNPs), rs2596538GA in the MICA promoter and rs1051792AG in the coding region (MICA-129Val/Met), influence MICA expression or binding to NKG2D, with MICA-129Met molecules showing higher receptor affinity. To investigate the impact of these SNPs on the occurrence of cytomegalovirus infection or acute rejection (AR) in individuals who underwent simultaneous pancreas–kidney transplantation (SPKT), 50 recipient-donor pairs were genotyped, and sMICA levels were measured during the first year post-transplantation. Recipients with a Val-mismatch (recipient Met/Met and donor Val/Met or Val/Val) showed shorter cytomegalovirus infection-free and shorter kidney AR-free survival. Additionally, Val mismatch was an independent predictor of cytomegalovirus infection and kidney AR in the first year post-transplantation. Interestingly, sMICA levels were lower in rs2596538AA and MICA129Met/Met-homozygous recipients. These results provide further evidence that genetic variants of MICA influence sMICA levels, and that Val mismatch at position 129 increases cytomegalovirus infection and kidney AR risk during the first year post-SPKT.

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