scholarly journals De Novo Emergence of Mesenchymal Stem-Like CD105 + Cancer Cells by Cytotoxic Agents in Human Hepatocellular Carcinoma

2017 ◽  
Vol 10 (2) ◽  
pp. 184-189 ◽  
Author(s):  
Yoshimoto Nomura ◽  
Taro Yamashita ◽  
Naoki Oishi ◽  
Kouki Nio ◽  
Takehiro Hayashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cancer Cells ◽  
De Novo ◽  
Human Hepatocellular Carcinoma ◽  
Cytotoxic Agents

scholarly journals De novo lipogenesis is elicited dramatically in human hepatocellular carcinoma especially in hepatitis C virus‐induced hepatocellular carcinoma

MedComm ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 178-187
Author(s):  
Shaojian Li ◽  
Ruonan Liu ◽  
Qinling Pan ◽  
Genshu Wang ◽  
Daorou Cheng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
De Novo ◽  
Human Hepatocellular Carcinoma ◽  
De Novo Lipogenesis

scholarly journals Alginate/CaCO3 Hybrid Loaded with Sorafenib Tosylate and Gold Hexagons: A Model for Efficient Dual (Chemo-Radio) Treatment of HepG2 Cells

2021 ◽  
Author(s):  
Firas A. Sukkar ◽  
Medhat W. Shafaa ◽  
Mohamed S. El-Nagdy ◽  
Soheir S. Korraa ◽  
wael darwish
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Hepg2 Cells ◽  
Human Hepatocellular Carcinoma ◽  
The Novel ◽  
Chemotherapeutic Drug ◽  
Hydrophobic Drug ◽  
Γ Radiation ◽  
Different Doses

Abstract In this work, we investigated the combinatorial cytotoxic actions of the chemotherapeutic drug (sorafenib tosylate, ST) in synergism with γ-radiation on human hepatocellular carcinoma (HepG2) cells. The novel radiosensitizer, hexagonal gold nanoparticles, was prepared and utilized To enhance the radiobiological response of HepG2 cells. A well-designed nanoporous alginate/CaCO3 hybrid was prepared as a biocompatible/biodegradable nanocarrier for co-delivery of the hydrophobic drug and the hydrophilic radiosensitizer to the cancer cells. Incubation of HepG2 cells with the nanoprobes followed by different doses (0, 3 or 6 Gy) of γ-radiation resulted in significant reduction of the cells viability as a result of the synergistic (chemo-radiation) cytotoxic actions.

Estrogen signalling through amphiregulin may be implicated in human hepatocellular carcinoma

2011 ◽  
Vol 5 (3) ◽  
pp. 153-160 ◽  
Author(s):  
Giuseppe Carruba ◽  
Vitale Miceli ◽  
Letizia Cocciadiferro ◽  
Maurizio Zarcone ◽  
Biagio Agostara ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Human Hepatocellular Carcinoma ◽  
Mrna Levels ◽  
Wild Type ◽  
Liver Cancer Cells ◽  
Huh7 Cells ◽  
Liver Tissues

AbstractBackground:We investigated aromatase (Aro)-driven estrogen formation in non-tumoral and malignant liver tissues and cells, also in relation to expression of the estrogen receptors α and β (ERα and ERβ) and amphiregulin (AREG), aiming to gain insights into the potential role of estrogens in human hepatocellular carcinoma (HCC).Materials and methods:Chromatographic and reverse transcriptase polymerase chain reaction (RT-PCR) analyses were used to assess activity and expression of the Aro enzyme and AREG as well as the expression of wild-type and variant ERs, both in vivo and in vitro.Results:Following 24 h and 72 h incubation of liver tissues or cells with testosterone, human HCC tissues and HepG2 hepatoma cells showed elevated Aro activity (estrogen formation, respectively, of 20% and 52%–99%). By contrast, no Aro activity could be detected in non-tumoral tissues and HA22T liver cancer cells. Cirrhotic samples and Huh7 cells exhibited intermediate enzyme activity, with estrogen formation of 4% and 34%, respectively. Markedly lower or undetectable Aro mRNA levels were observed in HA22T cells and non-tumoral liver tissues compared with HepG2 cells and HCC samples. Cirrhotic specimens displayed variable transcript levels. Interestingly, no or low expression of wild-type ERα and ERβ could be observed in liver cancer cells and malignant tissues. However, ubiquitous expression of the hERα46 variant and occasional expression of the hERβ2/Cx variant were observed in cancer tissues and cells.Conclusions:It is noteworthy that the pattern of wild-type ERα was inversely related to Aro, whilst AREG expression was consistently associated with that of Aro. This combined evidence suggests that locally elevated Aro activity may increase malignant cell proliferation also through AREG signalling.

scholarly journals The effects of hyperthermia on human hepatocellular carcinoma stem and mature cancer cells

2020 ◽  
Vol 19 (3) ◽  
pp. 265-268
Author(s):  
David Sontag ◽  
David A. Miles ◽  
Julia Uhanova ◽  
Micah Grubert Van Iderstine ◽  
Jiaqi Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cancer Cells ◽  
Human Hepatocellular Carcinoma

A fluorescent aptasensor for sensitive detection of human hepatocellular carcinoma SMMC-7721 cells based on graphene oxide

2014 ◽  
Vol 6 (17) ◽  
pp. 6809-6814 ◽  
Author(s):  
Qin Xie ◽  
Yuyu Tan ◽  
Qiuping Guo ◽  
Kemin Wang ◽  
Baoyin Yuan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Graphene Oxide ◽  
Cancer Cells ◽  
Direct Detection ◽  
Fluorescence Method ◽  
Human Hepatocellular Carcinoma ◽  
Sensitive Detection ◽  
Fluorescent Aptasensor

We developed a simple, rapid and sensitive fluorescence method for the direct detection of cancer cells using a GO-based aptasensor.

scholarly journals Anthocyanin-Rich Black Currant Extract Suppresses the Growth of Human Hepatocellular Carcinoma Cells

2010 ◽  
Vol 5 (10) ◽  
pp. 1934578X1000501 ◽  
Author(s):  
Anupam Bishayee ◽  
Erzsébet Háznagy-Radnai ◽  
Thomas Mbimba ◽  
Péter Sipos ◽  
Paolo Morazzoni ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Synergistic Effects ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Human Hepatocellular Carcinoma ◽  
Skin Extract ◽  
Black Currant ◽  
Liver Cancer Cells

Dietary antioxidants, such as anthocyanins, are helpful in the prevention and control of various diseases by counteracting the imbalance of oxidative and antioxidative factors in the living systems. Black currant (Ribes Nigrum L., Grossulariaceae) is known to contain high amounts of anthocyanins (250 mg/100 g fresh fruit). Black currant fruits have been used in Asian and European traditional medicine for the treatment of a variety of diseases. Black currant extract has recently been found to be the second most effective amongst nine different berry extracts studied for their free radical scavenging activity. Constituents present in black currant juice have been found to exert a number of health-promoting effects, including immunomodulatory, antimicrobial and antiinflammatory actions, inhibition of low-density lipoprotein, and reduction of cardiovascular diseases. Although antioxidant and antiinflammatory effects of black currant juice could be of value in preventing and treating oxidative stress- and inflammation-driven cancers, no experimental evidence is available to now. The objective of the present study was to evaluate the potential antiproliferative effects of black currant fruit skin extract against HepG2 human liver cancer cells. The aqueous extract yielded an anthocyanin-rich fraction with cyanidin-3 -O-rutinoside as one of the major anthocyanins. This fraction exhibited a potent cytotoxic effect on HepG2 cells and this effect was more pronounced than that of delphinidin and cyanidin, two major aglycones of anthocyanins present in black currant. Our results indicate, for the first time, that black currant skin containing an anthocyanin-rich fraction inhibits the proliferation of liver cancer cells, possibly due to additive as well as synergistic effects. This product could be useful in the prevention and treatment of human hepatocellular carcinoma.

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