Xenotropic murine leukaemia virus-related virus (XMRV) does not cause chronic fatigue

2011 ◽  
Vol 19 (11) ◽  
pp. 525-529 ◽  
Author(s):  
Mark J. Robinson ◽  
Otto Erlwein ◽  
Myra O. McClure
Keyword(s):  
Chronic Fatigue ◽  
Leukaemia Virus ◽  
Murine Leukaemia Virus ◽  
Related Virus

scholarly journals Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome

Retrovirology ◽  
2010 ◽  
Vol 7 (1) ◽  
pp. 10 ◽  
Author(s):  
Harriet CT Groom ◽  
Virginie C Boucherit ◽  
Kerry Makinson ◽  
Edward Randal ◽  
Sarah Baptista ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Leukaemia Virus ◽  
Murine Leukaemia Virus ◽  
Fatigue Syndrome ◽  
Related Virus

scholarly journals Structure of the xenotropic murine leukaemia virus-related virus matrix protein

Retrovirology ◽  
2011 ◽  
Vol 8 (Suppl 1) ◽  
pp. A227
Author(s):  
Michal Doležal ◽  
Iva Pichová ◽  
Tomáš Ruml ◽  
Richard Hrabal ◽  
Michaela Rumlová
Keyword(s):  
Matrix Protein ◽  
Leukaemia Virus ◽  
Murine Leukaemia Virus ◽  
Related Virus

scholarly journals Absence of xenotropic murine leukaemia virus-related virus in Danish patients with multiple sclerosis

Retrovirology ◽  
2011 ◽  
Vol 8 (Suppl 1) ◽  
pp. A213 ◽  
Author(s):  
Romana Maric ◽  
Finn S Pedersen ◽  
Anders Kjeldbjerg ◽  
Anné Moeller-Larsen ◽  
Shervin Bahrami ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Leukaemia Virus ◽  
Murine Leukaemia Virus ◽  
Related Virus

No evidence for a role of xenotropic murine leukaemia virus-related virus and BK virus in prostate cancer of German patients

2011 ◽  
Vol 201 (2) ◽  
pp. 245-248 ◽  
Author(s):  
Baki Akgül ◽  
David Pfister ◽  
Ruth Knüchel ◽  
Axel Heidenreich ◽  
Ulrike Wieland ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bk Virus ◽  
Leukaemia Virus ◽  
Murine Leukaemia Virus ◽  
Related Virus

Absence of xenotropic murine leukaemia virus-related virus in Danish patients with multiple sclerosis

2010 ◽  
Vol 49 (3) ◽  
pp. 227-228 ◽  
Author(s):  
Romana Maric ◽  
Finn S. Pedersen ◽  
Anders Kjeldbjerg ◽  
Anné Moeller-Larsen ◽  
Shervin Bahrami ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Leukaemia Virus ◽  
Murine Leukaemia Virus ◽  
Related Virus

scholarly journals Crystal structure of xenotropic murine leukaemia virus-related virus (XMRV) ribonuclease H

2012 ◽  
Vol 32 (5) ◽  
pp. 455-463 ◽  
Author(s):  
Ju Hee Kim ◽  
Sunghyun Kang ◽  
Suk-Kyeong Jung ◽  
Keum Ran Yu ◽  
Sang J. Chung ◽  
...  
Keyword(s):  
Rnase H ◽  
Ribonuclease H ◽  
Proper Function ◽  
Major Groove ◽  
Leukaemia Virus ◽  
Murine Leukaemia Virus ◽  
Related Virus ◽  
Phosphate Backbone ◽  
Structural Superposition ◽  
Direct Binding

RNase H (retroviral ribonuclease H) cleaves the phosphate backbone of the RNA template within an RNA/DNA hybrid to complete the synthesis of double-stranded viral DNA. In the present study we have determined the complete structure of the RNase H domain from XMRV (xenotropic murine leukaemia virus-related virus) RT (reverse transcriptase). The basic protrusion motif of the XMRV RNase H domain is folded as a short helix and an adjacent highly bent loop. Structural superposition and subsequent mutagenesis experiments suggest that the basic protrusion motif plays a role in direct binding to the major groove in RNA/DNA hybrid, as well as in establishing the co-ordination among modules in RT necessary for proper function.

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