scholarly journals Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort

BMJ ◽  
2010 ◽  
Vol 340 (feb25 1) ◽  
pp. c1018-c1018 ◽  
Author(s):  
F. J M van Kuppeveld ◽  
A. S d. Jong ◽  
K. H Lanke ◽  
G. W Verhaegh ◽  
W. J G Melchers ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
The Netherlands ◽  
Retrospective Analysis ◽  
Chronic Fatigue ◽  
Leukaemia Virus ◽  
Murine Leukaemia Virus ◽  
Fatigue Syndrome ◽  
Related Virus

scholarly journals Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome

Retrovirology ◽  
2010 ◽  
Vol 7 (1) ◽  
pp. 10 ◽  
Author(s):  
Harriet CT Groom ◽  
Virginie C Boucherit ◽  
Kerry Makinson ◽  
Edward Randal ◽  
Sarah Baptista ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Leukaemia Virus ◽  
Murine Leukaemia Virus ◽  
Fatigue Syndrome ◽  
Related Virus

scholarly journals A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus

mBio ◽  
2012 ◽  
Vol 3 (5) ◽  
Author(s):  
Harvey J. Alter ◽  
Judy A. Mikovits ◽  
William M. Switzer ◽  
Francis W. Ruscetti ◽  
Shyh-Ching Lo ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Xenotropic Murine Leukemia ◽  
Fatigue Syndrome ◽  
Related Virus ◽  
Murine Leukemia ◽  
Polytropic Murine Leukemia Virus

ABSTRACT The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leukemia virus (pMLV). Although the associations were not confirmed in subsequent studies by other investigators, patients continue to question the consensus of the scientific community in rejecting the validity of the association. Here we report blinded analysis of peripheral blood from a rigorously characterized, geographically diverse population of 147 patients with CFS/ME and 146 healthy subjects by the investigators describing the original association. This analysis reveals no evidence of either XMRV or pMLV infection. IMPORTANCE Chronic fatigue syndrome/myalgic encephalomyelitis has an estimated prevalence of 42/10,000 in the United States, with annual direct medical costs of $7 billion. Here, the original investigators who found XMRV and pMLV (polytropic murine leukemia virus) in blood of subjects with this disorder report that this association is not confirmed in a blinded analysis of samples from rigorously characterized subjects. The increasing frequency with which molecular methods are used for pathogen discovery poses new challenges to public health and support of science. It is imperative that strategies be developed to rapidly and coherently address discoveries so that they can be carried forward for translation to clinical medicine or abandoned to focus resource investment more productively. Our study provides a paradigm for pathogen dediscovery that may be helpful to others working in this field.

scholarly journals Xenotropic Murine Leukemia Virus–Related Virus Prevalence in Patients with Chronic Fatigue Syndrome or Chronic Immunomodulatory Conditions

2010 ◽  
Vol 202 (10) ◽  
pp. 1478-1481 ◽  
Author(s):  
Timothy J. Henrich ◽  
Jonathan Z. Li ◽  
Donna Felsenstein ◽  
Camille N. Kotton ◽  
Robert M. Plenge ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Chronic Fatigue ◽  
Virus Prevalence ◽  
Xenotropic Murine Leukemia ◽  
Fatigue Syndrome ◽  
Related Virus ◽  
Murine Leukemia

How fair is our service? Evaluating access to specialist paediatric care

2019 ◽  
Vol 104 (11) ◽  
pp. 1105-1107 ◽  
Author(s):  
Francesca K Neale ◽  
Edward J Armstrong ◽  
Jonathan M Cohen ◽  
Terry Y Segal ◽  
Dougal S Hargreaves
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Retrospective Analysis ◽  
Local Population ◽  
Chronic Fatigue ◽  
Outpatient Clinics ◽  
Rapid Access ◽  
Fatigue Syndrome ◽  
Paediatric Care ◽  
Paediatric Outpatient ◽  
Equity Of Access

ObjectiveTo assess equity of access to paediatric outpatient clinics in our hospital.Design/settingRetrospective analysis of consecutive accepted referrals to allergy, asthma, epilepsy, general paediatrics, rapid access, chronic fatigue syndrome, diabetes and endocrine outpatient clinics.Patients32 369 new patients, April 2007 to June 2018.ResultsAmong local patients (58.1%) 0.2%–2.5% of patients referred to each clinic lived in the least deprived quintile, and 43.5%–48.4% in the most deprived quintile—similar to inpatient admissions and the local population. Tertiary clinics showed a much higher proportion of patients from the least deprived quintiles (15.9%–26.2%).ConclusionsLocal outpatient referrals broadly reflected the socioeconomic distribution, although not necessarily the distribution of need, of our local population. A relatively high proportion of patients in tertiary clinics were from more affluent postcodes, highlighting the need for referral inequalities to be evaluated across networks or regions.

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